Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Critical Reviews™ in Biomedical Engineering
SJR: 0.26 SNIP: 0.375 CiteScore™: 1.4

ISSN Imprimir: 0278-940X
ISSN En Línea: 1943-619X

Volumes:
Volumen 48, 2020 Volumen 47, 2019 Volumen 46, 2018 Volumen 45, 2017 Volumen 44, 2016 Volumen 43, 2015 Volumen 42, 2014 Volumen 41, 2013 Volumen 40, 2012 Volumen 39, 2011 Volumen 38, 2010 Volumen 37, 2009 Volumen 36, 2008 Volumen 35, 2007 Volumen 34, 2006 Volumen 33, 2005 Volumen 32, 2004 Volumen 31, 2003 Volumen 30, 2002 Volumen 29, 2001 Volumen 28, 2000 Volumen 27, 1999 Volumen 26, 1998 Volumen 25, 1997 Volumen 24, 1996 Volumen 23, 1995

Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.v40.i4.40
pages 279-294

Toward Prediction of Immune Mechanisms and Design of Immunotherapies in Melanoma

Sophia Tsoka
Centre for Bioinformatics, Department of Informatics, School of Natural and Mathematical Sciences, King's College London
Chrysanthi Ainali
Cutaneous Medicine and Immunotherapy Unit, St. John's Institute of Dermatology, Division of Genetics and Molecular Medicine, NIHR Biomedical Research Centre at Guy's and St. Thomas's Hospitals and King's College London
Panagiotis Karagiannis
Cutaneous Medicine and Immunotherapy Unit, St. John's Institute of Dermatology, Division of Genetics and Molecular Medicine, NIHR Biomedical Research Centre at Guy's and St. Thomas's Hospitals and King's College London
Debra H. Josephs
Cutaneous Medicine and Immunotherapy Unit, St. John's Institute of Dermatology, Division of Genetics and Molecular Medicine, NIHR Biomedical Research Centre at Guy's and St. Thomas's Hospitals and King's College London
Louise Saul
Cutaneous Medicine and Immunotherapy Unit, St. John's Institute of Dermatology, Division of Genetics and Molecular Medicine, NIHR Biomedical Research Centre at Guy's and St. Thomas's Hospitals and King's College London
Frank O. Nestle
Cutaneous Medicine and Immunotherapy Unit, St. John's Institute of Dermatology, Division of Genetics and Molecular Medicine, NIHR Biomedical Research Centre at Guy's and St. Thomas's Hospitals and King's College London
Sophia N. Karagiannis
Cutaneous Medicine and Immunotherapy Unit, St. John's Institute of Dermatology, Division of Genetics and Molecular Medicine, NIHR Biomedical Research Centre at Guy's and St. Thomas's Hospitals and King's College London

SINOPSIS

Malignant melanoma, the most lethal skin cancer, is considered as a representative model for cross talk between immune responses and malignancy. Efforts to elucidate the nature of these interactions have translated into immunotherapeutic strategies. Adjuvant therapeutics such as IL-2 and IFNα2b have reached clinical application, and emerging therapies targeting key immunomodulatory molecules such as CTLA-4 have renewed excitement in the field, highlighting the potential of manipulating immune responses in the clinical setting, but also the merits for further elucidating complex underlying immunological pathways. Screening technologies have yielded new insights leading to identification of biomarkers for disease prognosis and applied clinical immunotherapies. The promise of systems biology is to integrate diverse biomedical characterizations into detailed models of underlying mechanisms and therapies through suitable computational and mathematical formalisms. In this review, we discuss recent developments in dissecting the complex and diverse immune responses associated with melanoma through both computational and experimental means. We show the significance of devising new, improved approaches that can better serve as models of immune interactions and therapies. We propose that efforts in this direction may realize the potential of personalized medicine and facilitate development of the next generation of efficacious tools to treat patients.


Articles with similar content:

Targeting MicroRNAs: Promising Future Therapeutics in the Treatment of Allergic Airway Disease
Critical Reviews™ in Eukaryotic Gene Expression, Vol.28, 2018, issue 2
Nicole G. Hansbro, Kamal Dua, Philip M. Hansbro, Paul S. Foster
Immunopathogenesis of Colitis-Associated Cancer in an Animal Model
Critical Reviews™ in Eukaryotic Gene Expression, Vol.25, 2015, issue 3
Chuan-Xing Xiao, Bayasi Guleng, Jun-Lin Zhao
Targeting PI3 Kinase/AKT/mTOR Signaling in Cancer
Critical Reviews™ in Oncogenesis, Vol.17, 2012, issue 1
Kathryn M Kinross, Benjamin Solomon, Karen Sheppard, Wayne A. Phillips, Richard B. Pearson
Immunotherapeutic Approaches for Glioma
Critical Reviews™ in Immunology, Vol.29, 2009, issue 1
Xinmei Zhu, Gary Kohanbash, Mitsugu Fujita, Aki Hoji, Ryo Ueda, Edward R. Kastenhuber, Hideho Okada
T-Cell Vaccination in Multiple Sclerosis: Immunoregulatory Mechanism and Prospects for Therapy
Critical Reviews™ in Immunology, Vol.21, 2001, issue 1-3
Jingwu Zhang