Suscripción a Biblioteca: Guest
Critical Reviews™ in Biomedical Engineering

Publicado 6 números por año

ISSN Imprimir: 0278-940X

ISSN En Línea: 1943-619X

SJR: 0.262 SNIP: 0.372 CiteScore™:: 2.2 H-Index: 56

Indexed in

Microbubbles as Ultrasound Contrast Agents and in Targeted Drug Delivery

Volumen 36, Edición 4, 2008, pp. 235-265
DOI: 10.1615/CritRevBiomedEng.v36.i4.10
Get accessGet access

SINOPSIS

The development of microbubbles has had considerable impact on the field of diagnostic ultrasound. These minute, gas- or lipid-filled spheres have enabled imaging in the kidney, liver, heart, and myocardium with resolutions that were previously unachievable. Insonation of these microagents generates high-energy cavitational oscillations, which, in addition to providing contrast, can increase local drug diffusivity through microstreaming or bubble collapse. The ability of focused insonation to induce such collapse on ligated microbubbles offers opportunities to deliver targeted therapies in novel ways. Microbubbles have had considerable impact on cancer research in terms of both imagining tumors and through the delivery of therapeutic agents and on the delivery of substances across biological obstructions such as the blood-brain barrier. This review offers a discussion of current approaches used in microbubble construction, of the underlying physics involved in their creation and destruction, and of current applications for these particles, the latter demonstrating their importance for high-contrast medical ultrasound. Challenges to overcome and future areas of microbubble application are also discussed.

CITADO POR
  1. Sirsi Shashank R., Hernandez Sonia L., Zielinski Lukasz, Blomback Henning, Koubaa Adel, Synder Milo, Homma Shunichi, Kandel Jessica J., Yamashiro Darrell J., Borden Mark A., Polyplex-microbubble hybrids for ultrasound-guided plasmid DNA delivery to solid tumors, Journal of Controlled Release, 157, 2, 2012. Crossref

  2. Warram Jason M., de Boer Esther, Sorace Anna G., Chung Thomas K., Kim Hyunki, Pleijhuis Rick G., van Dam Gooitzen M., Rosenthal Eben L., Antibody-based imaging strategies for cancer, Cancer and Metastasis Reviews, 33, 2-3, 2014. Crossref

  3. Robson Stephen, Fetal ultrasound screening and diagnosis 10 years hence, Prenatal Diagnosis, 30, 7, 2010. Crossref

  4. Hermanns M.I., Freese C., Anspach L., Grützner V., Pohl C., Unger R.E., Kirkpatrick C.J., 3.15 Cell Culture Systems for Studying Biomaterial Interactions With Biological Barriers ☆, in Comprehensive Biomaterials II, 2017. Crossref

  5. Yue Peijian, Miao Wang, Gao Lin, Zhao Xinyu, Teng Junfang, Ultrasound-Triggered Effects of the Microbubbles Coupled to GDNF Plasmid-Loaded PEGylated Liposomes in a Rat Model of Parkinson's Disease, Frontiers in Neuroscience, 12, 2018. Crossref

  6. Ghalichi F, Behnia S, Mottaghi F, Yahyavi M, Numerical study on a polymer-shelled microbubble submerged in soft tissue, Physica Scripta, 95, 8, 2020. Crossref

Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones Precios y Políticas de Suscripcione Begell House Contáctenos Language English 中文 Русский Português German French Spain