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Critical Reviews™ in Oncogenesis

Publicado 4 números por año

ISSN Imprimir: 0893-9675

ISSN En Línea: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Raf Kinase Inhibitory Protein (RKIP): Functional Pleiotropy in the Mammalian Brain

Volumen 19, Edición 6, 2014, pp. 505-516
DOI: 10.1615/CritRevOncog.2014011899
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SINOPSIS

In 1984, a cytosolic protein was isolated from bovine brain and coined phosphatidylethanolamine binding protein (PEBP) to describe its phospholipid-binding potential. Its cellular function remained elusive for more than a decade until it was discovered that PEBP had the ability to suppress the Raf1-mitogen activated protein kinase (MAPK) pathway, earning it the new name of Raf1 kinase inhibitory protein (RKIP). This milestone discovery has paved the way for numerous studies that have now extended the reach of RKIP's function to other signaling cascades, within the context of various physiological and pathophysiological systems. This review will summarize our current knowledge of the neurophysiological roles of RKIP in the mammalian brain, including its function in the circadian clock and synaptic plasticity. It will also discuss evidence for an involvement of RKIP and its derived neuropeptide, hippocampal cholinergic neurostimulating peptide (HCNP), in neural development and differentiation. Implications in certain pathologies such as Alzheimer's disease and brain cancer will be highlighted. By chronicling the diverse functions of RKIP in the brain, we hope that this review will serve as a timely resource that ignites future studies on this versatile, multifaceted protein in the nervous system.

CITADO POR
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  4. Piedrahita Diego, Castro-Alvarez John Fredy, Boudreau Ryan L., Villegas-Lanau Andres, Kosik Kenneth S., Gallego-Gomez Juan Carlos, Cardona-Gómez Gloria Patricia, β-Secretase 1’s Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice, Frontiers in Cellular Neuroscience, 9, 2016. Crossref

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  12. Parate Shraddha, Rampogu Shailima, Lee Gihwan, Hong Jong Chan, Lee Keun Woo, Exploring the Binding Interaction of Raf Kinase Inhibitory Protein With the N-Terminal of C-Raf Through Molecular Docking and Molecular Dynamics Simulation, Frontiers in Molecular Biosciences, 8, 2021. Crossref

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  15. Huang Quanfang, Wei Jinbin, Wei Ling, Zhang Xiaolin, Bai Facheng, Wen Shujuan, Wei Yuanyuan, Tan Shimei, Lu Zhongpeng, Lin Xing, Retracted : Role of RKIP in human hepatic stellate cell proliferation, invasion, and metastasis , Journal of Cellular Biochemistry, 120, 4, 2019. Crossref

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