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Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2.2

ISSN Imprimir: 0893-9675
ISSN En Línea: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.2018025927
pages 119-138

Radiation and Brain Tumors: An Overview

Michael Grunert
Department of Radiology, German Armed Forces Hospital of Ulm, Ulm, Germany; Department of Nuclear Medicine, German Armed Forces Hospital of Ulm, Ulm, Germany
Rebecca Kassubek
Department of Neurology, University of Ulm, Ulm, Germany
Burkhardt Danz
Department of Radiology, German Armed Forces Hospital of Ulm, Ulm, Germany
Burkhard Klemenz
Department of Nuclear Medicine, German Armed Forces Hospital of Ulm, Ulm, Germany
Sebastian Hasslacher
Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany
Sebastien Stroh
Department of Neurology, University of Ulm, Ulm, Germany; Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany
Lukas Schneele
Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany
Julia Langhans
Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany
Stephanie Ströbele
Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany
Sara E. Barry
School of Built and Natural Environment, Glasgow Caledonian University, Glasgow, Scotland
Shaoxia Zhou
Department of Clinical Chemistry, University Medical Center Ulm, Ulm, Germany
Klaus-Michael Debatin
Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany
Mike-Andrew Westhoff
Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany

SINOPSIS

The use of radiation is an essential part of both modern cancer diagnostic assessment and treatment. Next-generation imaging devices create 3D visualizations, allowing for better diagnoses and improved planning of precision treatment. This is particularly important for primary brain cancers such as diffuse intrinsic pontine glioma or the most common primary brain tumor, glioblastoma, because radiotherapy is often the only treatment modality that offers a significant improvement in survival and quality of life. In this review, we give an overview of the different imaging techniques and the historic role of radiotherapy and its place in modern cancer therapy. Finally, we discuss three key areas of risks associated with the use of ionizing radiation: (1) brain tumor induction mainly as a consequence of the diagnostic use of radiation; (2) cognitive decline as a consequence of treating childhood brain tumors as an example of long term consequences often neglected in favor of highlighting secondary primary cancers; and (3) pro-proliferative and pro-invasive alterations that occur in tumor cells that survive radiotherapy. Throughout the discussion, we highlight areas of potential future research.


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