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Critical Reviews™ in Oncogenesis

Publicado 4 números por año

ISSN Imprimir: 0893-9675

ISSN En Línea: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

CREB and Leukemogenesis

Volumen 16, Edición 1-2, 2011, pp. 37-46
DOI: 10.1615/CritRevOncog.v16.i1-2.50
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SINOPSIS

Acute myeloid leukemia (AML) is one of the most common leukemias with a 20% 5-year event-free survival in adults and 50% overall survival in children, despite aggressive chemotherapy treatment and bone marrow transplantation. The incidence and mortality rates for acute leukemia have only slightly decreased over the last 20 years, and therefore greater understanding of the molecular mechanisms associated with leukemic progression is needed. To this end, a number of transcription factors that appear to play a central role in leukemogenesis are being investigated; among them is the cAMP response element binding protein (CREB). CREB is a transcription factor that can regulate downstream targets involving in various cellular functions including cell proliferation, survival, and differentiation. In several studies, the majority of bone marrow samples from patients with acute lymphoid and myeloid leukemia demonstrate CREB overexpression. Moreover, CREB overexpression is associated with a poor outcome in AML patients. This review summarizes the role of CREB in leukemogenesis.

CITADO POR
  1. Boyle Joseph J., Heme and haemoglobin direct macrophage Mhem phenotype and counter foam cell formation in areas of intraplaque haemorrhage, Current Opinion in Lipidology, 23, 5, 2012. Crossref

  2. Gausdal G, Wergeland A, Skavland J, Nguyen E, Pendino F, Rouhee N, McCormack E, Herfindal L, Kleppe R, Havemann U, Schwede F, Bruserud Ø, Gjertsen B T, Lanotte M, Ségal-Bendirdjian E, Døskeland S O, Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis, Cell Death & Disease, 4, 2, 2013. Crossref

  3. Westbom Catherine M., Shukla Anurag, MacPherson Maximilian B., Yasewicz Elizabeth C., Miller Jill M., Beuschel Stacie L., Steele Chad, Pass Harvey I., Vacek Pamela M., Shukla Arti, CREB-Induced Inflammation Is Important for Malignant Mesothelioma Growth, The American Journal of Pathology, 184, 10, 2014. Crossref

  4. Sakamoto Kathleen M., Grant Steven, Saleiro Diana, Crispino John D., Hijiya Nobuko, Giles Francis, Platanias Leonidas, Eklund Elizabeth A., Targeting novel signaling pathways for resistant acute myeloid leukemia, Molecular Genetics and Metabolism, 114, 3, 2015. Crossref

  5. Fajardo Alexandra, Piazza Gary, Tinsley Heather, The Role of Cyclic Nucleotide Signaling Pathways in Cancer: Targets for Prevention and Treatment, Cancers, 6, 1, 2014. Crossref

  6. Teich Andrew F., Nicholls Russell E., Puzzo Daniela, Fiorito Jole, Purgatorio Rosa, Fa’ Mauro, Arancio Ottavio, Synaptic Therapy in Alzheimer’s Disease: A CREB-centric Approach, Neurotherapeutics, 12, 1, 2015. Crossref

  7. Wang Yakun, Hao Xiaoqiong, Yang Jing, Li Jia, Zhang Meijia, CREB activity is required for luteinizing hormone-induced the expression of EGF-like factors, Molecular Reproduction and Development, 83, 12, 2016. Crossref

  8. Li GuiPeng, Li Ming, Zhang YiWei, Wang Dong, Li Rong, Guimerà Roger, Gao Juntao Tony, Zhang Michael Q., Tosatto Silvio C. E., ModuleRole: A Tool for Modulization, Role Determination and Visualization in Protein-Protein Interaction Networks, PLoS ONE, 9, 5, 2014. Crossref

  9. Xia H., Gong Z., Lian Y., Zhou J., Wang X., Gene Expression Profile Regulated by CREB in K562 Cell Line, Transplantation Proceedings, 48, 6, 2016. Crossref

  10. DI NISIO CHIARA, SANCILIO SILVIA, DI GIACOMO VIVIANA, RAPINO MONICA, SANCILLO LAURA, GENOVESI DOMENICO, DI SIENA ALESSANDRO, RANA ROSA ALBA, CATALDI AMELIA, DI PIETRO ROBERTA, Involvement of cyclic-nucleotide response element-binding family members in the radiation response of Ramos B lymphoma cells, International Journal of Oncology, 48, 1, 2016. Crossref

  11. Casalvieri Kimberly A., Matheson Christopher J., Backos Donald S., Reigan Philip, Selective Targeting of RSK Isoforms in Cancer, Trends in Cancer, 3, 4, 2017. Crossref

  12. Wang Xue, Cui Hui, Lou Zhongguan, Huang Shuaishuai, Ren Yu, Wang Ping, Weng Guobin, Cyclic AMP responsive element-binding protein induces metastatic renal cell carcinoma by mediating the expression of matrix metallopeptidase-2/9 and proteins associated with epithelial-mesenchymal transition, Molecular Medicine Reports, 15, 6, 2017. Crossref

  13. HU FEN, MENG YANAN, GOU LIXIA, ZHANG XIUJUN, Analysis of promoters and CREB/AP-1 binding sites of the human TMEM174 gene, Experimental and Therapeutic Medicine, 6, 5, 2013. Crossref

  14. Martinelli Chiara, Signaling Landscape of AML: The Story So Far, in Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs, 2018. Crossref

  15. Lu Saihua, Zhou Xiaofan, Li Zhuman, Guo Zhijun, Yang Zheng, Ma Minghua, Xu Feng, Propranolol Inhibits Androgen Deprivation-induced Neuroendocrine Differentiation of Prostate Cancer, International Journal of Pharmacology, 15, 8, 2019. Crossref

  16. Akın Balı Dilara Fatma, Pediatrik öncü B-ALL’ye Moleküler Yaklaşım, Zeynep Kamil Tıp Bülteni, 2019. Crossref

  17. Müller-Längle , Lutz , Hehlgans , Rödel , Rau , Laube , NMDA Receptor-Mediated Signaling Pathways Enhance Radiation Resistance, Survival and Migration in Glioblastoma Cells—A Potential Target for Adjuvant Radiotherapy, Cancers, 11, 4, 2019. Crossref

  18. Yu Qingfeng, Xu Ying, Zhuang Haifeng, Wu Zhaoxing, Zhang Lei, Li Jinfan, Yang Linlin, Wu Bowen, Wang Ping, Zhang Xuzhao, Gan Xiaoxian, Liang Yun, Zheng Shu, Yu Xiaofang, Gu Ying, Xu Rongzhen, Aberrant activation of RPB1 is critical for cell overgrowth in acute myeloid leukemia, Experimental Cell Research, 384, 2, 2019. Crossref

  19. Steven André, Seliger Barbara, Control of CREB expression in tumors: from molecular mechanisms and signal transduction pathways to therapeutic target, Oncotarget, 7, 23, 2016. Crossref

  20. Zhuang Haihui, Meng Xiangyu, Li Yanyuan, Wang Xue, Huang Shuaishuai, Liu Kaitai, Hehir Michael, Fang Rong, Jiang Lei, Zhou Jeff X., Wang Ping, Ren Yu, Cyclic AMP responsive element-binding protein promotes renal cell carcinoma proliferation probably via the expression of spindle and kinetochore-associated protein 2, Oncotarget, 7, 13, 2016. Crossref

  21. Ednersson Susanne Bram, Stern Mimmie, Fagman Henrik, Nilsson-Ehle Herman, Hasselblom Sverker, Andersson Per-Ola, TBLR1 and CREBBP as potential novel prognostic immunohistochemical biomarkers in diffuse large B-cell lymphoma, Leukemia & Lymphoma, 61, 11, 2020. Crossref

  22. Steven André, Leisz Sandra, Sychra Katharina, Hiebl Bernhard, Wickenhauser Claudia, Mougiakakos Dimitrios, Kiessling Rolf, Denkert Carsten, Seliger Barbara, Hypoxia-mediated alterations and their role in the HER-2/neuregulated CREB status and localization, Oncotarget, 7, 32, 2016. Crossref

  23. Steven André, Leisz Sandra, Wickenhauser Claudia, Schulz Kristin, Mougiakakos Dimitrios, Kiessling Rolf, Denkert Carsten, Seliger Barbara, Linking CREB function with altered metabolism in murine fibroblast-based model cell lines, Oncotarget, 8, 57, 2017. Crossref

  24. Perez Dominique R., Sklar Larry A., Chigaev Alexandre, Matlawska-Wasowska Ksenia, Drug repurposing for targeting cyclic nucleotide transporters in acute leukemias - A missed opportunity, Seminars in Cancer Biology, 68, 2021. Crossref

  25. Bruserud Øystein, Reikvam Håkon, Fredly Hanne, Skavland Jørn, Hagen Karen-Marie, van Hoang Tuyen Thy, Brenner Annette K., Kadi Amir, Astori Audrey, Gjertsen Bjørn Tore, Pendino Frederic, Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells - high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation, Oncotarget, 6, 5, 2015. Crossref

  26. Casalvieri Kimberly A., Matheson Christopher J., Backos Donald S., Reigan Philip, Substituted pteridinones as p90 ribosomal S6 protein kinase (RSK) inhibitors: A structure-activity study, Bioorganic & Medicinal Chemistry, 28, 5, 2020. Crossref

  27. Steven André, Friedrich Michael, Jank Paul, Heimer Nadine, Budczies Jan, Denkert Carsten, Seliger Barbara, What turns CREB on? And off? And why does it matter?, Cellular and Molecular Life Sciences, 77, 20, 2020. Crossref

  28. Friedrich Michael, Heimer Nadine, Stoehr Christine, Steven André, Wach Sven, Taubert Helge, Hartmann Arndt, Seliger Barbara, CREB1 is affected by the microRNAs miR-22-3p, miR-26a-5p, miR-27a-3p, and miR-221-3p and correlates with adverse clinicopathological features in renal cell carcinoma, Scientific Reports, 10, 1, 2020. Crossref

  29. Illiano Michela, Conte Mariarosaria, Salzillo Alessia, Ragone Angela, Spina Annamaria, Nebbioso Angela, Altucci Lucia, Sapio Luigi, Naviglio Silvio, The KDM Inhibitor GSKJ4 Triggers CREB Downregulation via a Protein Kinase A and Proteasome-Dependent Mechanism in Human Acute Myeloid Leukemia Cells, Frontiers in Oncology, 10, 2020. Crossref

  30. Kour Akeen, Sambyal Vasudha, Guleria Kamlesh, Singh Neeti Rajan, Uppal Manjit Singh, Manjari Mridu, Sudan Meena, In silico pathway analysis based on chromosomal instability in breast cancer patients, BMC Medical Genomics, 13, 1, 2020. Crossref

  31. Sapio Luigi, Salzillo Alessia, Ragone Angela, Illiano Michela, Spina Annamaria, Naviglio Silvio, Targeting CREB in Cancer Therapy: A Key Candidate or One of Many? An Update, Cancers, 12, 11, 2020. Crossref

  32. Youn Minyoung, Gomez Jesus Omar, Mark Kailen, Sakamoto Kathleen M., RSK Isoforms in Acute Myeloid Leukemia, Biomedicines, 9, 7, 2021. Crossref

  33. Stati Gianmarco, Passaretta Francesca, Gindraux Florelle, Centurione Lucia, Di Pietro Roberta, The Role of the CREB Protein Family Members and the Related Transcription Factors in Radioresistance Mechanisms, Life, 11, 12, 2021. Crossref

  34. Villicaña Claudia, Cruz Grisel, Zurita Mario, The basal transcription machinery as a target for cancer therapy, Cancer Cell International, 14, 1, 2014. Crossref

  35. Teich Andrew F., Arancio Ottavio, Is the Amyloid Hypothesis of Alzheimer's disease therapeutically relevant?, Biochemical Journal, 446, 2, 2012. Crossref

  36. Lu Fangjin, Zheng Ying, Donkor Paul Owusu, Zou Peng, Mu Ping, Downregulation of CREB Promotes Cell Proliferation by Mediating G1/S Phase Transition in Hodgkin Lymphoma, Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, 24, 3, 2016. Crossref

  37. Wooten David J., Gebru Melat, Wang Hong-Gang, Albert Réka, Data-Driven Math Model of FLT3-ITD Acute Myeloid Leukemia Reveals Potential Therapeutic Targets, Journal of Personalized Medicine, 11, 3, 2021. Crossref

  38. Steven André, Leisz Sandra, Massa Chiara, Iezzi Manuela, Lattanzio Rossano, Lamolinara Alessia, Bukur Jürgen, Müller Anja, Hiebl Bernhard, Holzhausen Hans-Jürgen, Seliger Barbara, HER-2/neu Mediates Oncogenic Transformation via Altered CREB Expression and Function, Molecular Cancer Research, 11, 11, 2013. Crossref

  39. Ahmed Muhammad Bilal, Alghamdi Abdullah A. A., Islam Salman Ul, Lee Joon-Seok, Lee Young-Sup, cAMP Signaling in Cancer: A PKA-CREB and EPAC-Centric Approach, Cells, 11, 13, 2022. Crossref

  40. Yamada Tadaaki, Amann Joseph M., Fukuda Koji, Takeuchi Shinji, Fujita Naoya, Uehara Hisanori, Iwakiri Shotaro, Itoi Kazumi, Shilo Konstantin, Yano Seiji, Carbone David P., Akt Kinase-Interacting Protein 1 Signals through CREB to Drive Diffuse Malignant Mesothelioma, Cancer Research, 75, 19, 2015. Crossref

  41. Li Bin E., Ernst Patricia, Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia, Experimental Hematology, 42, 12, 2014. Crossref

  42. Nubile Mario, Curcio Claudia, Lanzini Manuela, Calienno Roberta, Iezzi Manuela, Mastropasqua Alessandra, Di Nicola Marta, Mastropasqua Leonardo, Expression of CREB in Primary Pterygium and Correlation with Cyclin D1, ki-67, MMP7, p53, p63, Survivin and Vimentin, Ophthalmic Research, 50, 2, 2013. Crossref

  43. Wang Guanqiao, Cheng Zhenguo, Liu Funan, Zhang Hongyan, Li Jiabin, Li Feng, CREB is a key negative regulator of carbonic anhydrase IX (CA9) in gastric cancer, Cellular Signalling, 27, 7, 2015. Crossref

  44. Feng Yan-Rong, Raza Sayed Haidar Abbas, Liang Cheng-Cheng, Wang Xiao-Yu, Wang Jian-Fang, Zhang Wen-Zheng, Zan Linsen, CREB1 promotes proliferation and differentiation by mediating the transcription of CCNA2 and MYOG in bovine myoblasts, International Journal of Biological Macromolecules, 216, 2022. Crossref

  45. Guo Kai-Min, Li Wei, Wang Zhao-Hua, He Lang-Chi, Feng Yan, Liu Hui-Shu, Low-dose aspirin inhibits trophoblast cell apoptosis by activating the CREB/Bcl-2 pathway in pre-eclampsia, Cell Cycle, 2022. Crossref

  46. Kakoo Ashraf, Al-Attar Mustafa, Rasheed Taban, Exonic variants in multiple myeloma patients associated with relapsed/ refractory and response to bortezomib regimens, Saudi Journal of Biological Sciences, 29, 1, 2022. Crossref

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