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Critical Reviews™ in Therapeutic Drug Carrier Systems

Publicado 6 números por año

ISSN Imprimir: 0743-4863

ISSN En Línea: 2162-660X

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.7 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 3.6 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.8 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00023 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.39 SJR: 0.42 SNIP: 0.89 CiteScore™:: 5.5 H-Index: 79

Indexed in

The Role of Surface Functionalization in the Design of PLGA Micro- and Nanoparticles

Volumen 27, Edición 1, 2010, pp. 1-83
DOI: 10.1615/CritRevTherDrugCarrierSyst.v27.i1.10
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SINOPSIS

Nano- and microcarriers prepared from the biocompatible and biodegradable polymer poly(D,L-lactide-co-glycolide) (PLGA) are being extensively studied for drug-delivery purposes. Apart from size, their fate in the body is mainly determined by surface characteristics that govern the interaction of the particles with their environment. The present review provides an overview of the currently established concepts for the surface functionalization of particles made from PLGA. In the frst part, a concise description of the material-borne surface features and the related functionalization strategies are given, followed by current methods for the physical and chemical characterization of the particle surface. The second part highlights the aims of functionalization, which include improved drug delivery, vaccination, and imaging. Targeting approaches for site-specifc delivery of drug-loaded particles to certain tissues or even to intracellular targets are presented, as well as stealth coatings for a prolonged blood circulation, labeling methods for imaging purposes, and strategies for the immobilization of macromolecular drugs on the particle surface. Finally, present limitations and future challenges will be discussed, with a focus on the surface-modification procedure and essential demands on functional particulate systems posed by the dynamic and complex in vivo environment.

CITADO POR
  1. Babiuch Krzysztof, Gottschaldt Michael, Werz Oliver, Schubert Ulrich S., Particulate transepithelial drug carriers: barriers and functional polymers, RSC Advances, 2, 28, 2012. Crossref

  2. Ferenz Katja B., Waack Indra N., Mayer Christian, de Groot Herbert, Kirsch Michael, Long-circulating poly(ethylene glycol)-coated poly(lactid-co-glycolid) microcapsules as potential carriers for intravenously administered drugs, Journal of Microencapsulation, 30, 7, 2013. Crossref

  3. Leclercq Laurent, Modena Enrico, Vert Michel, Adsorption of proteins at physiological concentrations on pegylated surfaces and the compatibilizing role of adsorbed albumin with respect to other proteins according to optical waveguide lightmode spectroscopy (OWLS), Journal of Biomaterials Science, Polymer Edition, 24, 13, 2013. Crossref

  4. Adams J. R., Goswami M., Pohl N. L. B., Mallapragada S. K., Synthesis and functionalization of virus-mimicking cationic block copolymers with pathogen-associated carbohydrates as potential vaccine adjuvants, RSC Advances, 4, 30, 2014. Crossref

  5. Velmurugan Ramaiyan, Selvamuthukumar Subramanian, In Vivo Antitumor Activity of a Novel Orally Bioavailable Ifosfamide Nanostructured Lipid Carrier Against Dalton’s Ascitic Lymphoma, Journal of Pharmaceutical Innovation, 9, 3, 2014. Crossref

  6. Pranke Patricia, Weibel Daniel E., Braghirolli Daikelly I., Electrospun Scaffolds of Biodegradable Polyesters: Manufacturing and Biomedical Application, in Biodegradable Polyesters, 2015. Crossref

  7. Barker Ian A., Hall Daniel J., Hansell Claire F., Du Prez Filip E., O'Reilly Rachel K., Dove Andrew P., Tetrazine-Norbornene Click Reactions to Functionalize Degradable Polymers Derived from Lactide, Macromolecular Rapid Communications, 32, 17, 2011. Crossref

  8. Zhuang Jian, Guo Renfei, Li Fei, Yu Dehong, Large-scale and non-contact surface topography measurement using scanning ion conductance microscopy and sub-aperture stitching technique, Measurement Science and Technology, 27, 8, 2016. Crossref

  9. Kirsch M., Bramey T., Waack I. N., Petrat F., Mayer C., de Groot H., The necessity for the coating of perfluorodecalin-filled poly(lactide-co-glycolide) microcapsules in the presence of physiological cholate concentrations: Tetronic-908 as an exemplary polymeric surfactant, Journal of Microencapsulation, 29, 1, 2012. Crossref

  10. Lee Yen-Chun, Chen Chaomei, Tsai Xing-Tzu, Visualizing the Knowledge Domain of Nanoparticle Drug Delivery Technologies: A Scientometric Review, Applied Sciences, 6, 1, 2016. Crossref

  11. Sequeira Joana A.D., Pereira Irina, Ribeiro António J., Veiga Francisco, Santos Ana Cláudia, Surface functionalization of PLGA nanoparticles for drug delivery, in Handbook of Functionalized Nanomaterials for Industrial Applications, 2020. Crossref

  12. Al-Natour Mohammad A., Yousif Mohamed D., Cavanagh Robert, Abouselo Amjad, Apebende Edward A., Ghaemmaghami Amir, Kim Dong-Hyun, Aylott Jonathan W., Taresco Vincenzo, Chauhan Veeren M., Alexander Cameron, Facile Dye-Initiated Polymerization of Lactide–Glycolide Generates Highly Fluorescent Poly(lactic-co-glycolic Acid) for Enhanced Characterization of Cellular Delivery, ACS Macro Letters, 9, 3, 2020. Crossref

  13. Diesner Susanne C, Wang Xue-Yan, Jensen-Jarolim Erika, Untersmayr Eva, Gabor Franz, Use of lectin-functionalized particles for oral immunotherapy, Therapeutic Delivery, 3, 2, 2012. Crossref

  14. Vermonden Tina, Censi Roberta, Hennink Wim E., Hydrogels for Protein Delivery, Chemical Reviews, 112, 5, 2012. Crossref

  15. Chen Xiaoming, Liu Yuying, Wang Lianyan, Liu Yuan, Zhang Weifeng, Fan Bei, Ma Xiaowei, Yuan Qipeng, Ma Guanghui, Su Zhiguo, Enhanced Humoral and Cell-Mediated Immune Responses Generated by Cationic Polymer-Coated PLA Microspheres with Adsorbed HBsAg, Molecular Pharmaceutics, 11, 6, 2014. Crossref

  16. Tezcan Tugba, Hsu Chia-Hsien, Nanotechnology in healthcare: nanoparticles for diagnostic and therapy, in Biotechnology in Healthcare, Volume 1, 2022. Crossref

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