Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Critical Reviews™ in Therapeutic Drug Carrier Systems
Factor de Impacto: 2.9 Factor de Impacto de 5 años: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN Imprimir: 0743-4863
ISSN En Línea: 2162-660X

Volumes:
Volumen 36, 2019 Volumen 35, 2018 Volumen 34, 2017 Volumen 33, 2016 Volumen 32, 2015 Volumen 31, 2014 Volumen 30, 2013 Volumen 29, 2012 Volumen 28, 2011 Volumen 27, 2010 Volumen 26, 2009 Volumen 25, 2008 Volumen 24, 2007 Volumen 23, 2006 Volumen 22, 2005 Volumen 21, 2004 Volumen 20, 2003 Volumen 19, 2002 Volumen 18, 2001 Volumen 17, 2000 Volumen 16, 1999 Volumen 15, 1998 Volumen 14, 1997 Volumen 13, 1996 Volumen 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v24.i1.20
pages 41-62

Lipid-Based Cochleates: A Promising Formulation Platform for Oral and Parenteral Delivery of Therapeutic Agents

Ravi Rao
College of Pharmacy and Allied Health Professions, St. John's University, Queens, NY 11439
Emilio Squillante, III
College of Pharmacy and Allied Health Professions, St. John's University, Queens, NY 11439, USA
Kwon H. Kim
College of Pharmacy and Allied Health Professions, St. John's University, Queens, NY 11439

SINOPSIS

Cochleates are lipid-based supramolecular assemblies that display great potential as delivery systems for systemic delivery of drugs, including peptides, proteins, vaccines, oligonucleotides, and genes. This is mainly attributed to their high stability and biocompatibility and their ability to deliver both hydrophilic and lipophilic drugs. Cochleates have a unique multilayered spiral structure, which is composed of a negatively charged phospholipid and a divalent cation, and can encapsulate diverse drug molecules of various shapes and sizes while minimizing toxicity associated with polymeric materials present in micro- and nanoparticle systems. This review describes current technological advances in the preparation methods, physicochemical characterization, and potential applications of cochleates as a drug delivery system for systemic delivery of various types of therapeutic agents.


Articles with similar content:

Current Nanotechnological Strategies for Effective Delivery of Bioactive Drug Molecules in the Treatment of Tuberculosis
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.31, 2014, issue 1
Mandeep Kaur, Goutam Rath, Tarun Garg, Amit Kumar Goyal
Pharmaceutical and Biomedical Potential of Surface Engineered Dendrimers
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.24, 2007, issue 3
Narendra Kumar Jain, Umesh Gupta, Jitendra Satija
Overview on Therapeutic Applications of Microparticulate Drug Delivery Systems
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.33, 2016, issue 4
Swarna Bale, Mandip Singh, A. Shiva Shankar Reddy, Amit Khurana, Chandraiah Godugu
Polymeric Lipid Hybrid Nanoparticles: Properties and Therapeutic Applications
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.35, 2018, issue 6
Kesrin Amra, Munira Momin, Chintan Bhavsar, Abdelwahab Omri, Cyril Jose
Nano-Aggregates: Emerging Delivery Tools for Tumor Therapy
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.30, 2013, issue 6
Vinod Kumar Sharma, Ankit Jain, Vandana Soni