Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Critical Reviews™ in Therapeutic Drug Carrier Systems
Factor de Impacto: 2.9 Factor de Impacto de 5 años: 3.72 SJR: 0.736 SNIP: 0.818 CiteScore™: 4.6

ISSN Imprimir: 0743-4863
ISSN En Línea: 2162-660X

Volumes:
Volumen 37, 2020 Volumen 36, 2019 Volumen 35, 2018 Volumen 34, 2017 Volumen 33, 2016 Volumen 32, 2015 Volumen 31, 2014 Volumen 30, 2013 Volumen 29, 2012 Volumen 28, 2011 Volumen 27, 2010 Volumen 26, 2009 Volumen 25, 2008 Volumen 24, 2007 Volumen 23, 2006 Volumen 22, 2005 Volumen 21, 2004 Volumen 20, 2003 Volumen 19, 2002 Volumen 18, 2001 Volumen 17, 2000 Volumen 16, 1999 Volumen 15, 1998 Volumen 14, 1997 Volumen 13, 1996 Volumen 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v13.i3-4.20
pages 225-256

The Role of Scanning Probe Microscopy in Drug Delivery Research

Kevin M. Shakesheff
EPSRC Advanced Fellow. Tissue Engineering Group School of Pharmaceutical Sciences The University of Nottingham Nottingham NG7 2RD United Kingdom
Martyn C. Davies
Laboratory of Biophysics and Surface Analysis, Department of Pharmaceutical Science, The University of Nottingham, University Park, Nottingham, NG7 2RD, United Kingdom
Clive Roberts
School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK
Saul J. B. Tendler
Laboratory of Biophysics and Surface Analysis, Department of Pharmaceutical Science, The University of Nottingham, University Park, Nottingham, NG7 2RD, United Kingdom
Philip M. Williams
Laboratory of Biophysics and Surface Analysis, Department of Pharmaceutical Science, The University of Nottingham, University Park, Nottingham, NG7 2RD, United Kingdom

SINOPSIS

The success of a drug delivery system is often dependent on the surface properties of the device. These surface properties will determine the complex dynamic interfacial events that occur when the system is introduced into the aqueous environment of a patient. Development of the scanning probe microscopes has provided a number of very powerful new surface analytical techniques that are making a significant contribution to the characterization of drug delivery systems and the interfacial processes that occur when such systems are exposed to aqueous living environments. In this review, we describe the design and attributes of these instruments and discuss the impact of the techniques on a wide range of drug delivery research. The scanning probe microscopes are providing new insights into important problems concerning drug delivery, including the molecular structure of polymeric biomaterial surfaces, the conformation of target biomolecules, the influence of morphology on biodegradation, the adsorption of proteins to synthetic surfaces, and the structure and interactions of colloidal particles. As the whole field of scanning probe microscopy continues to advance, drug delivery research is set to benefit, in the final section of the review, the future potential derived from the ability to characterize new surface properties under aqueous conditions is discussed.


Articles with similar content:

Microbubbles as Ultrasound Contrast Agents and in Targeted Drug Delivery
Critical Reviews™ in Biomedical Engineering, Vol.36, 2008, issue 4
Oi Lei Wong, Peter Sheffield, Brendan Boyd, Aastha Trehan
Colloidal Drug Delivery Systems: Current Status and Future Directions
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.32, 2015, issue 2
Goutam Rath, Tarun Garg, Amit Kumar Goyal
Colloidosomes: An Emerging Vesicular System in Drug Delivery
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.24, 2007, issue 4
Yashwant Gupta, Satish Shilpi, Anekant Jain, Sanjay Kumar Jain
Lipid-Based Nanoparticles as Pharmaceutical Drug Carriers: From Concepts to Clinic
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.26, 2009, issue 6
Eliahu Heldman, Kristin Loomis, Brandon Smith, Anu Puri, Jae-Ho Lee, Amichai Yavlovich, Robert Blumenthal
The Role of Surface Functionalization in the Design of PLGA Micro- and Nanoparticles
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.27, 2010, issue 1
Michael Wirth, Vera Kerleta, Christian Fillafer, Franz Gabor, Gerda Ratzinger