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Critical Reviews™ in Immunology

Publicado 6 números por año

ISSN Imprimir: 1040-8401

ISSN En Línea: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Avelumab: A Novel Anti-PD-L1 Agent in the Treatment of Merkel Cell Carcinoma and Urothelial Cell Carcinoma

Volumen 38, Edición 3, 2018, pp. 159-206
DOI: 10.1615/CritRevImmunol.2018025204
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SINOPSIS

Long-term treatment in the setting of metastatic Merkel cell carcinoma (MCC) and urothelial carcinoma (UC) has shown that current first-line chemotherapeutic agents are losing effectiveness and that there are limited treatment options available outside of radiation therapy and surgical interventions. The use of immunotherapeutic agents such as monoclonal antibodies has been considered a promising alternative for cancers that progress despite treatment with radiation therapy, surgery, and/or chemotherapeutic agents. Cancer cells escape immune surveillance by interrupting immune checkpoint pathways, resulting in dysregulation of T-cell function and so preventing its antitumor effects. In early 2017, avelumab (BAVENCIO®), a PD-L1–blocking monoclonal antibody agent, was approved for the treatment of metastatic MCC and UC. Trials that evaluated avelumab for the treatment of metastatic MCC and UC were the JAVELIN Merkel 200 Trial and the JAVELIN Solid Tumor trial, respectively. Efficacy results for both trials showed positive overall response rate (ORR) and progression-free survival rate (PFS). A strong safety profile was also established for avelumab. This review provides a brief introduction to checkpoint inhibitors and focuses on the recently approved PD-L1 inhibitor, avelumab.

CITADO POR
  1. Barrueto Luisa, Caminero Francheska, Cash Lindsay, Makris Courtney, Lamichhane Purushottam, Deshmukh Rahul R., Resistance to Checkpoint Inhibition in Cancer Immunotherapy, Translational Oncology, 13, 3, 2020. Crossref

  2. Barbari Cody, Fontaine Tyler, Parajuli Priyanka, Lamichhane Narottam, Jakubski Silvia, Lamichhane Purushottam, Deshmukh Rahul R., Immunotherapies and Combination Strategies for Immuno-Oncology, International Journal of Molecular Sciences, 21, 14, 2020. Crossref

  3. Mortensen Michael J, Oatman Oliver, Azadi Amir, Fonkem Ekokobe, Yuen Kevin CJ, An Update on Immune Checkpoint Inhibitor-related Hypophysitis, US Endocrinology, 16, 2, 2020. Crossref

  4. Zhukova N. V., Orlova R. V., Kaledina E. A., Naymushina P. A., Malkova A. M., Beliak N. P., Key differences between anti-PD-1/PD-L1 inhibitors, Meditsinskiy sovet = Medical Council, 9, 2022. Crossref

  5. Orlova Rashida, Zhukova Natalia, Malkova Anna, Shoenfeld Yehuda, Hypothesis for the development of immune-related adverse events in immune checkpoint inhibitors therapy, Cancer Treatment and Research Communications, 31, 2022. Crossref

  6. Maghrouni Abolfazl, Givari Maryam, Jalili-Nik Mohammad, Mollazadeh Hamid, Bibak Bahram, Sadeghi Mohammad Montazami, Afshari Amir R., Johnston Thomas P., Sahebkar Amirhossein, Targeting the PD-1/PD-L1 pathway in glioblastoma multiforme: Preclinical evidence and clinical interventions, International Immunopharmacology, 93, 2021. Crossref

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