Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Critical Reviews™ in Immunology
Factor de Impacto: 1.404 Factor de Impacto de 5 años: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472

Volumen 40, 2020 Volumen 39, 2019 Volumen 38, 2018 Volumen 37, 2017 Volumen 36, 2016 Volumen 35, 2015 Volumen 34, 2014 Volumen 33, 2013 Volumen 32, 2012 Volumen 31, 2011 Volumen 30, 2010 Volumen 29, 2009 Volumen 28, 2008 Volumen 27, 2007 Volumen 26, 2006 Volumen 25, 2005 Volumen 24, 2004 Volumen 23, 2003 Volumen 22, 2002 Volumen 21, 2001 Volumen 20, 2000 Volumen 19, 1999 Volumen 18, 1998 Volumen 17, 1997 Volumen 16, 1996 Volumen 15, 1995 Volumen 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v19.i5-6.10
40 pages

Transplantation Tolerance: A Look at the Nonhuman Primate Literature in the Light of Modern Tolerance Theories

Allan D. Kirk
NIDDK/Navy-Transplant and Autoimmunity Branch, 10 Center Drive, Bldg. 10, Room 11S219, Bethesda, MD 20892


Ever since the beginning of clinical transplantation, investigators have searched for a way to transplant tissues from one person to another without chronic immunosuppression. That goal, known as allograft tolerance, has remained clinically elusive. In the past decade, however, many of the fundamental principles of tolerance have been redefined, and biological agents capable of exploiting them in vivo have been developed. Accordingly, experimental methods for tolerance induction have rapidly evolved in concert with a growing understanding of physiological tolerance to self and the development of novel immunoreactive reagents. In general, old world monkeys have become the pre-clinical testing ground for methods that have shown reasonable promise for clinical application, particularly antibodies or other biological agents with limited cross-species reactivity. As such, a survey of the nonhuman primate experience in transplantation is representative of all reasonably successful experimental attempts to develop clinically applicable tolerance regimens. This article summarizes many of the concepts currently unfolding in the tolerance literature. It also reviews the techniques for tolerance induction that have been and are currently being investigated in nonhuman primates. The validity of these models is summarized, and the older literature is reinterpreted in light of recent changes in our understanding of tolerance.

Articles with similar content:

T-Cell Vaccination in Multiple Sclerosis: Immunoregulatory Mechanism and Prospects for Therapy
Critical Reviews™ in Immunology, Vol.21, 2001, issue 1-3
Jingwu Zhang
Cellular Components and Mechanisms of Oral Tolerance Induction
Critical Reviews™ in Immunology, Vol.38, 2018, issue 3
Rafael M. Rezende, Howard L. Weiner
The Fetus and the Maternal Immune System: Pregnancy as a Model to Study Peripheral T-Cell Tolerance
Critical Reviews™ in Immunology, Vol.19, 1999, issue 5-6
Shi-Ping Jiang, Melanie S. Vacchio
Recent Advances and Challenges in Studies of Control of Cancer Stem Cells and the Gut Microbiome by the Trametes-Derived Polysaccharopeptide PSP (Review)
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 8
Joseph M. Wu, Qingyao Yang, Barbara B. Doonan, Xiao-Tong Yang, Tze-chen Hsieh, Ming-Tat Ling
Delivery of Biotherapeutics by Inhalation Aerosol
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.12, 1995, issue 2-3
Ralph W. Niven