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Critical Reviews™ in Immunology
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ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v14.i3-4.30
pages 239-292

The Role of Cytokines in Gestation

Sarah A. Robertson
The Department of Obstetrics and Gynaecology, The University of Adelaide, Adelaide, South Australia
Robert F. Seamark
The Department of Obstetrics and Gynaecology, The University of Adelaide, Adelaide, South Australia
Larry J. Guilbert
The Department of Immunology, The University of Alberta, Edmonton, Alberta, Canada
Thomas G. Wegmann
The Department of Immunology, The University of Alberta, Edmonton, Alberta, Canada

SINOPSIS

Lymphohemopoietic cytokines are now recognized to be central participants in the cellular communication events underlying the complex and dynamic remodeling processes required to accommodate the semiallogeneic conceptus during mammalian reproduction. Cytokines are identified to be particular importance in mediating communications between the conceptus and maternal cells, particularly the uterine epithelium and infiltrating leukocytes, both prior to implantation and as the placenta develops. In this review we summarize recent experimental data concerning the synthesis of various cytokines in uterine and conceptus-derived tissues and highlight current hypotheses for their roles in establishing and maintaining successful pregnancy. It is concluded that complex and finely balanced cytokine networks underpin precise regulatory mechanisms controlling the rate and degree of conceptus development and invasion into maternal tissues.


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