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Critical Reviews™ in Immunology
Factor de Impacto: 1.404 Factor de Impacto de 5 años: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v24.i2.30
28 pages

Measles Virus Infection and Vaccination: Potential Role in Chronic Illness and Associated Adverse Events

Ronald C. Kennedy
Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, TX 79430
Vera S. Byers
Department of Dermatology, University of California, San Francisco, San Francisco, CA94143
John J. Marchalonis
Department of Immunobiology, University of Arizona College of Medicine P.O. Box 24-5049 Tucson, AZ 85724


Over the last decade, a number of concerns have arisen related to safety issues that have had an adverse effect on the public's trust, particularly among parents whose children are the primary recipient of the vaccine. Historically, the live attenuated measles virus (MV) vaccine and the combination multivalent measles, mumps, and rubella (MMR) vaccine have had a major impact on the health of children worldwide and have been extremely successful at preventing infectious diseases associated with three childhood viral pathogens. In this report, we describe MV infection, replication, pathogenesis, and immunization. MV is a viral pathogen that exhibits a number of complex processes that can effect its replication, pathogenesis, and the induction of an effective antiviral immune response. We describe the published literature as it relates to MV infection and immunization and report adverse events in an attempt to provide a balanced discussion and an historical perspective of the MMR vaccine and autism.

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