Suscripción a Biblioteca: Guest
Critical Reviews™ in Immunology

Publicado 6 números por año

ISSN Imprimir: 1040-8401

ISSN En Línea: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

PART III. Autoimmunity
An Altered Peptide Ligand of Type II Collagen Suppresses Autoimmune Arthritis

Volumen 27, Edición 4, 2007, pp. 345-356
DOI: 10.1615/CritRevImmunol.v27.i4.40
Get accessGet access

SINOPSIS

On the basis of the hypothesis that immunity to type II collagen (CII) contributes to joint inflammation, our goal is to develop an immunotherapy capable of selectively blocking immunity to a particular autoantigen without interfering with the beneficial functions of the immune system. CII is the major protein component of articular cartilage and autoimmunity to CII is strongly associated with rheumatoid arthritis in man. Our laboratory has previously identified a region of type II collagen (CII), CII245−270 that contains a prominent T-cell epitope in the immune response to CII. Residues critical to the I-Aq-restricted presentation of this determinant have been characterized. When synthetic analog peptides were developed that contain site-directed substitutions in critical positions, we found that that CII245−270 (A260, B261, N263) (A9), profoundly suppressed collagen-induced arthritis. When DBA/1 mice were coimmunized with CII and the analog peptide, the incidence and severity of arthritis was greatly reduced concordant with the humoral immune responses to CII. Moreover, the suppression could be transferred with A9-immune spleen cells and was accompanied by a Th2-type cytokine profile. When we compared T-cell signals in response to A9 to those of wild-type (WT) peptide, we found that APCs prepulsed with WT peptide induced strong phosphorylation of both TCR ζ chain and Zap-70, while A9 did not. Since T cells clearly respond to A9 with cytokine secretion, we hypothesize that A9 induces an alternate signaling pathway and we speculate that this pathway involves phosphorylation of Syk, a kinase ordinarily utilized by B cells. Activation of this alternative pathway is a novel observation and may represent an important means by which the phenotype of the responding T cell is altered. Elucidation of the mechanism by which A9 prevents arthritis may lead to development of novel immunotherapeutic approaches to antigen specific treatment of autoimmunity.

CITADO POR
  1. Czaja Albert J., Emerging Opportunities for Site-Specific Molecular and Cellular Interventions in Autoimmune Hepatitis, Digestive Diseases and Sciences, 55, 10, 2010. Crossref

  2. Myers Linda K., Cullins David L., Park Jeoung-Eun, Yi Ae-Kyung, Brand David D., Rosloniec Edward F., Stuart John M., Kang Andrew H., Peptide ligand structure and I-Aq binding avidity influence T cell signaling pathway utilization, Clinical Immunology, 160, 2, 2015. Crossref

  3. Katsara Maria, Minigo Gabriela, Plebanski Magdalena, Apostolopoulos Vasso, The good, the bad and the ugly: how altered peptide ligands modulate immunity, Expert Opinion on Biological Therapy, 8, 12, 2008. Crossref

  4. Braun Ruedi K., Martin Alicia, Shah Shivanee, Iwashima Makio, Medina Melissa, Byrne Kathryn, Sethupathi Periannan, Wigfield Christopher H., Brand David D., Love Robert B., Inhibition of bleomycin-induced pulmonary fibrosis through pre-treatment with collagen type V, The Journal of Heart and Lung Transplantation, 29, 8, 2010. Crossref

  5. Jensen Kirk D.C., Sercarz Eli E., Gabaglia Claudia Raja, Altered peptide ligands can modify the Th2 T cell response to the immunodominant 161-175 peptide of LACK (Leishmania homolog for the receptor of activated C kinase), Molecular Immunology, 46, 3, 2009. Crossref

  6. Myers Linda K., Cullins David L., Brand David D., Kleinau Sandra, Stuart John M., Kang Andrew H., T cells stimulated with an analog peptide of type II collagen require the Fc receptor γ-chain to secrete interleukin-4 and suppress autoimmune arthritis in mice, Arthritis & Rheumatism, 63, 9, 2011. Crossref

  7. Park Jeoung-Eun, Rotondo Jeffrey A., Cullins David L., Brand David D., Yi Ae-Kyung, Stuart John M., Kang Andrew H., Myers Linda K., Characterization of the Syk-Dependent T Cell Signaling Response to an Altered Peptide, The Journal of Immunology, 197, 12, 2016. Crossref

  8. Dai Meilu, Liu Xin, Wang Nanping, Sun Jiao, Squid type II collagen as a novel biomaterial: Isolation, characterization, immunogenicity and relieving effect on degenerative osteoarthritis via inhibiting STAT1 signaling in pro-inflammatory macrophages, Materials Science and Engineering: C, 89, 2018. Crossref

  9. Park Jeoung-Eun, Majumdar Sirshendu, Brand David D., Rosloniec Edward F., Yi Ae-Kyung, Stuart John M., Kang Andrew H., Myers Linda K., The role of Syk in peripheral T cells, Clinical Immunology, 192, 2018. Crossref

  10. Xu Xiao, Sui Baiyan, Liu Xin, Sun Jiao, Superior low-immunogenicity of tilapia type I collagen based on unique secondary structure with single calcium binding motif over terrestrial mammals by inhibiting activation of DC intracellular Ca2+-mediated STIM1-Orai1/NF-кB pathway, Materials Science and Engineering: C, 131, 2021. Crossref

  11. De Santis M, Ceribelli A, Cavaciocchi F, Generali E, Massarotti M, Isailovic N, Crotti C, Scherer H U, Montecucco C, Selmi C, Effects of type II collagen epitope carbamylation and citrullination in human leucocyte antigen (HLA)-DR4+ monozygotic twins discordant for rheumatoid arthritis, Clinical and Experimental Immunology, 185, 3, 2016. Crossref

  12. Park Jeoung-Eun, Cullins David, Zalduondo Lillian, Barnett Stacey L., Yi Ae-Kyung, Kleinau Sandra, Stuart John M., Kang Andrew H., Myers Linda K., Molecular Basis for T Cell Response Induced by Altered Peptide Ligand of Type II Collagen, Journal of Biological Chemistry, 287, 23, 2012. Crossref

  13. Liu Zhenming, Li Bo, Li Xia, Zhang Liangren, Lai Luhua, Identification of Small-Molecule Inhibitors against Human Leukocyte Antigen-Death Receptor 4 (HLA-DR4) Through a Comprehensive Strategy, Journal of Chemical Information and Modeling, 51, 2, 2011. Crossref

  14. Wenhart Clara, Holthoff Hans-Peter, Reimann Andreas, Li Zhongmin, Faßbender Julia, Ungerer Martin, A fructosylated peptide derived from a collagen II T cell epitope for long-term treatment of arthritis (FIA-CIA) in mice, Scientific Reports, 11, 1, 2021. Crossref

  15. Page Audrey, Fusil Floriane, Cosset François-Loïc, Antigen-specific tolerance approach for rheumatoid arthritis: Past, present and future, Joint Bone Spine, 88, 4, 2021. Crossref

Próximos Artículos

Identification of a novel five-gene prognostic model for laryngeal cancer associated with mitophagy using integrated bioinformatics analysis and experimental verification Dong Song, Lun Dong, Mei Wang, Xiaoping Gao Function of steroid receptor coactivators (SRCs) in T cells and cancers: Implications for cancer immunotherapy Wencan Zhang, Xu Cao, Hongmin Wu, Xiancai Zhong, Yun Shi, Zuoming Sun Electroacupuncture Alleviates Ischemic Stroke by Activating the mTOR/SREBP1 Pathway Jiawang Lang, Jianchang Luo, Luodan Wang, Wenbin Xu, Jie Jia, Zhipeng Zhao, Boxu Lang KIAA1429 induces the m6A modification of LINC01106 to enhance the malignancy of lung adenocarcinoma cell via JAK/STAT3 pathway Di Xu, Ziming Wang, Fajiu Li Effect of p-estrogen receptor at serine on its function and breast growth Yuan Liang, Junhui Qin, Tiancheng Ma, Tong Yang, Zhenyu Ke, Ruian Wang Mechanistic Insights into Tanshinone IIA in the Amelioration of Post-Thyroidectomy Hypoparathyroidism Xiaoyu Qian, Lin Li, Liang Chen, Chao Shen, Jian Tang MiRNA let-7d-5p alleviates inflammatory responses by targeting Map3k1 and inactivating ERK/p38 MAPK signaling in microglia Fan Fang, Cheng Chen Role of Natural Killer Cells as Cell-Based Immunotherapy in Oral Tumor Eradication and Differentiation Both In Vivo and In Vitro Kawaljit Kaur, Anahid Jewett The Current and Future States of Natural Killer Cell-Based Immunotherapy in Hepatocellular Carcinoma Tu Nguyen, Po-Chun Chen, Janet Pham, Kawaljit Kaur, Steven Raman, Anahid Jewett, Jason Chiang Phillygenin alleviated arthritis through the inhibition of NLRP3 inflammasome and Ferroptosis by AMPK Jianghui Wang, Shufang Ni, Kai Zheng, Yan Zhao, peihong zhang, Hong Chang The value of systemic immune-inflammation index and T cell subsets in the severity and prognosis of sepsis Hao Zhou Efficacy and Nuances of Precision Molecular Engineering for Hodgkin's Disease to a Gene Therapeutic Approach Muhammad Imran Qadir, Bilal Ahmed, Nadir Hussain Serum interleukin 6 and ferritin levels are the independent risk factors for pneumonia in elderly patients Hao Yuan, Jing Tian, Lu Wen Exploration of diagnostic markers associated with inflammation in chronic kidney disease (CKD) based on WGCNA and machine learning Qianjia Wu, Yang Yang, Chongze Lin Clinical significance of serum CTRP3 level in the prediction of cardiac dysfunction and intestinal mucosal barrier dysfunction in patients with severe acute pancreatitis Qiang Shao, Lin Sun The protective effect and mechanism of mild hypothermia on pig lung injury after cardiopulmonary resuscitation Jinlin Ren, Fangfang Zhu, Dongdong Sang, Mulin Cong, Shujuan Jiang Exploring mechanism of Zilongjin in treating lung adenocarcinoma based on network pharmacology combined with experimental verification Kang Zhang, Xiaoqun Chen Gastric Cancer Immune Subtypes and Prognostic Modeling: Insights from Aging-Related Genes Analysis Jian Shen, Minzhe Li Effects of different doses of dexmedetomidine on the prevention of postoperative sleep disturbance and serum neurotransmitter level in patients under general anesthesia Huifei Lu, Fei He, Ying Huang, Zhongliang Wei Identification of key ubiquitination-related genes and their associated with immune infiltration in osteoarthritis based on mRNA-miRNA network Dalu Yuan, Hailiang Shen, Lina Bai, Menglin Li, Qiujie Ye Diagnostic and Prognostic value of peripheral neutrophil CD64 index in elderly patients with community-acquired pneumonia Yan Li, Jing Zhang, Suhang Wang, Jie Cao Identification of Metabolism-Related Prognostic Biomarkers and Immune Features of Head and Neck Squamous Cell Carcinoma Rongjin Zhou, Junguo Wang Downregulation of miR-503-5p promotes the development of pancreatic cancer via targeting cyclin E2 Fei Li, Ying-pei Ling, Pan Wang, Shi-cheng Gu, Hao Jiang, Jie Zhu
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones Precios y Políticas de Suscripcione Begell House Contáctenos Language English 中文 Русский Português German French Spain