Publicado 6 números por año
ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472
Indexed in
T-Cell Immunity to Influenza A Viruses
SINOPSIS
Influenza infection remains a global threat to human health. Influenza viruses are normally controlled by antibodies specific for the surface glycoproteins hemagglutinin (HA) and neuraminidase (NA). Standard influenza vaccines are aimed at inducing these antibodies, but they must be administered annually and can be rendered ineffective since different strains circulate from year to year and vary considerably in their individual HA and NA profiles. Influenza-specific T cells have been shown to be protective in animal models and typically recognize the more conserved internal influenza proteins. Improving our understanding of influenza-specific T-cell responses, including immunodominance, specific epitope sequences, strain-related epitope variation, host/virus interaction, and the balance between immunity versus immunopathology, will be important to improve future T-cell-based vaccines, which promise broader strain coverage and longer-lasting protection than current standard vaccines.
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Komadina Naomi, Quiñones-Parra Sergio M., Kedzierska Katherine, McCaw James M., Kelso Anne, Leder Karin, McVernon Jodie, High conservation level of CD8+T cell immunogenic regions within an unusual H1N2 human influenza variant, Journal of Medical Virology, 88, 10, 2016. Crossref
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Grant Emma J, Quiñones-Parra Sergio M, Clemens E Bridie, Kedzierska Katherine, Human influenza viruses and CD8+ T cell responses, Current Opinion in Virology, 16, 2016. Crossref
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Servín-Blanco R., Zamora-Alvarado R., Gevorkian G., Manoutcharian K., Antigenic variability: Obstacles on the road to vaccines against traditionally difficult targets, Human Vaccines & Immunotherapeutics, 12, 10, 2016. Crossref
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Duan Susu, Thomas Paul G., Balancing Immune Protection and Immune Pathology by CD8+ T-Cell Responses to Influenza Infection, Frontiers in Immunology, 7, 2016. Crossref
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Gutiérrez Andres H., Rapp-Gabrielson Vicki J., Terry Frances E., Loving Crystal L., Moise Leonard, Martin William D., De Groot Anne S., T-cell epitope content comparison (EpiCC) of swine H1 influenza A virus hemagglutinin, Influenza and Other Respiratory Viruses, 11, 6, 2017. Crossref
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Chen Li, Anthony Anjaleena, Oveissi Sara, Huang Miaojuan, Zanker Damien, Xiao Kun, Wu Chao, Zou Quanming, Chen Weisan, Broad-Based CD4+ T Cell Responses to Influenza A Virus in a Healthy Individual Who Lacks Typical Immunodominance Hierarchy, Frontiers in Immunology, 8, 2017. Crossref
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Krammer Florian, García-Sastre Adolfo, Palese Peter, Is It Possible to Develop a “Universal” Influenza Virus Vaccine?, Cold Spring Harbor Perspectives in Biology, 10, 7, 2018. Crossref
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Fox Annette, Quinn Kylie M., Subbarao Kanta, Extending the Breadth of Influenza Vaccines: Status and Prospects for a Universal Vaccine, Drugs, 78, 13, 2018. Crossref
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Estrada Leonardo D., Schultz-Cherry Stacey, Development of a Universal Influenza Vaccine, The Journal of Immunology, 202, 2, 2019. Crossref
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Jia Ran, Liu Shuai, Xu Jin, Liang Xiaozhen, IL16 deficiency enhances Th1 and cytotoxic T lymphocyte response against influenza A virus infection, BioScience Trends, 13, 6, 2019. Crossref
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Dai Manman, Xu Chenggang, Chen Weisan, Liao Ming, Progress on chicken T cell immunity to viruses, Cellular and Molecular Life Sciences, 76, 14, 2019. Crossref
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Corder Brigette N., Bullard Brianna L., DeBeauchamp Jennifer L., Ilyushina Natalia A., Webby Richard J., Weaver Eric A., Influenza H1 Mosaic Hemagglutinin Vaccine Induces Broad Immunity and Protection in Mice, Vaccines, 7, 4, 2019. Crossref
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Hu Jian, Chen Li, Yang Wuchen, Li Bin, Sun Heqiang, Wei Shanshan, He Yafei, Zhao Zhuo, Yang Shiming, Zou Quanming, Chen Weisan, Guo Hong, Wu Chao, Systematic identification of immunodominant CD4+ T cell responses to HpaA inHelicobacter pyloriinfected individuals, Oncotarget, 7, 34, 2016. Crossref
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Hensen Luca, Kedzierska Katherine, Koutsakos Marios, Innate and adaptive immunity toward influenza B viruses, Future Microbiology, 15, 11, 2020. Crossref
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Huang Miaojuan, Xu Rong, Triffon Cristina, Mifsud Nicole, Chen Weisan, Broad-Based Influenza-Specific CD8+ T Cell Response without the Typical Immunodominance Hierarchy and Its Potential Implication, Viruses, 13, 6, 2021. Crossref
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Mooney Alaina J., Gabbard Jon D., Li Zhuo, Dlugolenski Daniel A., Johnson Scott K., Tripp Ralph A., He Biao, Tompkins S. Mark, Schultz-Cherry Stacey, Vaccination with Recombinant Parainfluenza Virus 5 Expressing Neuraminidase Protects against Homologous and Heterologous Influenza Virus Challenge, Journal of Virology, 91, 23, 2017. Crossref