Publicado 6 números por año
ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472
Indexed in
Microenvironmental Hypoxia Orchestrating the Cell Stroma Cross Talk, Tumor Progression and Antitumor Response
SINOPSIS
Hypoxia, a common feature of solid tumors and one of the hallmarks of tumor microenvironment, favors tumor survival and progression. Although hypoxia has been reported to play a major role in the acquisition of tumor resistance to cell death, the molecular mechanisms that control the survival of hypoxic cancer cells and the role of hypoxic stress in shaping the cross talk between immune cells and stroma components are not fully elucidated. Recently, several lines of investigation are pointing to yet another ominous outcome of hypoxia in the tumor microenvironment involving suppression of antitumor immune effector cells and enhancement of tumor escape from immune surveillance. Although the identification of tumor-associated antigens provided a new arsenal of approaches to enhance antigen-specific response, the immunotherapy approaches that are currently used in the clinic have only limited success. In fact, tumor stroma components including hypoxia are engaged in an active molecular cross talk that has serious implications for immunological recognition of tumor in shaping the microenvironment. In this review, we will focus on the impact of hypoxia on the regulation of the antitumor response and the subsequent tumor progression. We will also in particular discuss data that indicate that manipulation of hypoxic stress may represent an innovative strategy for a better immunotherapy of cancer.
-
McNamee Eóin N., Korns Johnson Darlynn, Homann Dirk, Clambey Eric T., Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function, Immunologic Research, 55, 1-3, 2013. Crossref
-
Fridman Wolf-Herman, Dieu-Nosjean Marie-Caroline, Pagès Franck, Cremer Isabelle, Damotte Diane, Sautès-Fridman Catherine, Galon Jérôme, The Immune Microenvironment of Human Tumors: General Significance and Clinical Impact, Cancer Microenvironment, 6, 2, 2013. Crossref
-
Hirschfeld Marc, Zhang Bo, Jaeger Markus, Stamm Stefan, Erbes Thalia, Mayer Sebastian, Tong Xiaowen, Stickeler Elmar, Hypoxia-dependent mRNA expression pattern of splicing factor YT521 and its impact on oncological important target gene expression, Molecular Carcinogenesis, 53, 11, 2014. Crossref
-
Jasinski-Bergner Simon, Mandelboim Ofer, Seliger Barbara, The Role of MicroRNAs in the Control of Innate Immune Response in Cancer, JNCI: Journal of the National Cancer Institute, 106, 10, 2014. Crossref
-
Noman Muhammad Zaeem, Messai Yosra, Muret Jane, Hasmim Meriem, Chouaib Salem, Crosstalk between CTC, Immune System and Hypoxic Tumor Microenvironment, Cancer Microenvironment, 7, 3, 2014. Crossref
-
Chaudary Naz, Pintilie Melania, Schwock Joerg, Dhani Neesha, Clarke Blaise, Milosevic Michael, Fyles Anthony, Hill Richard P., Characterization of the Tumor-Microenvironment in Patient-Derived Cervix Xenografts (OCICx), Cancers, 4, 3, 2012. Crossref
-
Viry Elodie, Paggetti Jerome, Baginska Joanna, Mgrditchian Takouhie, Berchem Guy, Moussay Etienne, Janji Bassam, Autophagy: An adaptive metabolic response to stress shaping the antitumor immunity, Biochemical Pharmacology, 92, 1, 2014. Crossref
-
Song Kai, Song Yong, Zhao Xiao-Ping, Shen Hui, Wang Meng, Yan Ting-lin, Liu Ke, Shang Zheng-jun, Oral cancer/endothelial cell fusion experiences nuclear fusion and acquisition of enhanced survival potential, Experimental Cell Research, 328, 1, 2014. Crossref
-
Hasmim Meriem, Messai Yosra, Noman Muhammad Zaeem, Chouaib Salem, L’hypoxie tumorale, médecine/sciences, 30, 4, 2014. Crossref
-
Shang Qianwen, Dong Zhaojing, Liu Chunmei, Bai Yang, Guo Chun, Zhang Lining, Wang Qun, Differential effects of agonistic 4-1BB (CD137) monoclonal antibody on the maturation and functions of hypoxic dendritic cells, International Immunopharmacology, 23, 2, 2014. Crossref
-
Janji Bassam, Noman Muhammad Zaeem, Viry Elodie, Hasmim Meriem, Messai Yosra, Berchem Guy, Chouaib Fathia Mami, Chouaib Salem, Emerging Role of Hypoxia-Induced Autophagy in Cancer Immunotherapy, in Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, 2014. Crossref
-
Berchem Guy, Noman Muhammad Zaeem, Bosseler Manon, Paggetti Jerome, Baconnais Sonia, Le cam Eric, Nanbakhsh Arash, Moussay Etienne, Mami-Chouaib Fathia, Janji Bassam, Chouaib Salem, Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transfer, OncoImmunology, 5, 4, 2016. Crossref
-
Messai Yosra, Noman Muhammad Zaeem, Hasmim Meriem, Escudier Bernard, Chouaib Salem, HIF-2α/ITPR1 axis: A new saboteur of NK-mediated lysis, OncoImmunology, 4, 2, 2015. Crossref
-
Aparicio Luis A., Blanco Moisés, Castosa Raquel, Concha Ángel, Valladares Manuel, Calvo Lourdes, Figueroa Angélica, Clinical implications of epithelial cell plasticity in cancer progression, Cancer Letters, 366, 1, 2015. Crossref
-
Balamurugan Kuppusamy, HIF-1 at the crossroads of hypoxia, inflammation, and cancer, International Journal of Cancer, 138, 5, 2016. Crossref
-
Hasmim Meriem, Messai Yosra, Ziani Linda, Thiery Jerome, Bouhris Jean-Henri, Noman Muhammad Zaeem, Chouaib Salem, Critical Role of Tumor Microenvironment in Shaping NK Cell Functions: Implication of Hypoxic Stress, Frontiers in Immunology, 6, 2015. Crossref
-
Noman Muhammad Zaeem, Janji Bassam, Berchem Guy, Chouaib Salem, miR-210 and hypoxic microvesicles: Two critical components of hypoxia involved in the regulation of killer cells function, Cancer Letters, 380, 1, 2016. Crossref
-
Shiozawa Toshihiro, Iyama Shinji, Toshima Shotaro, Sakata Akiko, Usui Shingo, Minami Yuko, Sato Yukio, Hizawa Nobuyuki, Noguchi Masayuki, Dimethylarginine dimethylaminohydrolase 2 promotes tumor angiogenesis in lung adenocarcinoma, Virchows Archiv, 468, 2, 2016. Crossref
-
Basudhar Debashree, Somasundaram Veena, de Oliveira Graciele Almeida, Kesarwala Aparna, Heinecke Julie L., Cheng Robert Y., Glynn Sharon A., Ambs Stefan, Wink David A., Ridnour Lisa A., Nitric Oxide Synthase-2-Derived Nitric Oxide Drives Multiple Pathways of Breast Cancer Progression, Antioxidants & Redox Signaling, 26, 18, 2017. Crossref
-
Lunardi P., Beauval J.-B., Roumiguié M., Soulié M., Cuvillier O., Malavaud B., Mécanismes de résistance à la castration : l’hypoxie intratumorale stimule l’expression du récepteur aux androgènes, Progrès en Urologie, 26, 3, 2016. Crossref
-
Kheshtchin Nasim, Arab Samaneh, Ajami Maryam, Mirzaei Reza, Ashourpour Mahboubeh, Mousavi Neda, Khosravianfar Najmeh, Jadidi-Niaragh Farhad, Namdar Afshin, Noorbakhsh Farshid, Hadjati Jamshid, Inhibition of HIF-1α enhances anti-tumor effects of dendritic cell-based vaccination in a mouse model of breast cancer, Cancer Immunology, Immunotherapy, 65, 10, 2016. Crossref
-
Wu Min-Zu, Cheng Wei-Chung, Chen Su-Feng, Nieh Shin, O’Connor Carolyn, Liu Chia-Lin, Tsai Wen-Wei, Wu Cheng-Jang, Martin Lorena, Lin Yaoh-Shiang, Wu Kou-Juey, Lu Li-Fan, Izpisua Belmonte Juan Carlos, miR-25/93 mediates hypoxia-induced immunosuppression by repressing cGAS, Nature Cell Biology, 19, 10, 2017. Crossref
-
Campillo Noelia, Torres Marta, Vilaseca Antoni, Nonaka Paula Naomi, Gozal David, Roca-Ferrer Jordi, Picado César, Montserrat Josep Maria, Farré Ramon, Navajas Daniel, Almendros Isaac, Role of Cyclooxygenase-2 on Intermittent Hypoxia-Induced Lung Tumor Malignancy in a Mouse Model of Sleep Apnea, Scientific Reports, 7, 1, 2017. Crossref
-
Shi Shujing, Wang Rui, Chen Yitian, Song Haizhu, Chen Longbang, Huang Guichun, Gelovani Juri G., Combining Antiangiogenic Therapy with Adoptive Cell Immunotherapy Exerts Better Antitumor Effects in Non-Small Cell Lung Cancer Models, PLoS ONE, 8, 6, 2013. Crossref
-
Noman Muhammad Zaeem, Hasmim Meriem, Messai Yosra, Terry Stéphane, Kieda Claudine, Janji Bassam, Chouaib Salem, Hypoxia: a key player in antitumor immune response. A Review in the Theme: Cellular Responses to Hypoxia, American Journal of Physiology-Cell Physiology, 309, 9, 2015. Crossref
-
Kouidhi Soumaya, Elgaaied Amel Benammar, Chouaib Salem, Impact of Metabolism in on T-Cell Differentiation and Function and Cross Talk with Tumor Microenvironment, Frontiers in Immunology, 8, 2017. Crossref
-
Lappano Rosamaria, Maggiolini Marcello, GPER is involved in the functional liaison between breast tumor cells and cancer-associated fibroblasts (CAFs), The Journal of Steroid Biochemistry and Molecular Biology, 176, 2018. Crossref
-
Rhost Sara, Hughes Éamon, Harrison Hannah, Rafnsdottir Svanheidur, Jacobsson Hanna, Gregersson Pernilla, Magnusson Ylva, Fitzpatrick Paul, Andersson Daniel, Berger Karoline, Ståhlberg Anders, Landberg Göran, Sortilin inhibition limits secretion-induced progranulin-dependent breast cancer progression and cancer stem cell expansion, Breast Cancer Research, 20, 1, 2018. Crossref
-
Janji Bassam, Berchem Guy, Chouaib Salem, Targeting Autophagy in the Tumor Microenvironment: New Challenges and Opportunities for Regulating Tumor Immunity, Frontiers in Immunology, 9, 2018. Crossref
-
Ray Deepak, Khoshchehreh Reyhaneh, Aicher Alexandra, Heeschen Christopher, Pancreatic Cancer Stem Cells, in Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology, 2015. Crossref
-
Saetersmoen Michelle L., Hammer Quirin, Valamehr Bahram, Kaufman Dan S., Malmberg Karl-Johan, Off-the-shelf cell therapy with induced pluripotent stem cell-derived natural killer cells, Seminars in Immunopathology, 41, 1, 2019. Crossref
-
Li Yiliang, Patel Sapna Pradyuman, Roszik Jason, Qin Yong, Hypoxia-Driven Immunosuppressive Metabolites in the Tumor Microenvironment: New Approaches for Combinational Immunotherapy, Frontiers in Immunology, 9, 2018. Crossref
-
Riefolo Mattia, Porcellini Elisa, Dika Emi, Broseghini Elisabetta, Ferracin Manuela, Interplay between small and long non‐coding RNA s in cutaneous melanoma: a complex jigsaw puzzle with missing pieces , Molecular Oncology, 13, 1, 2019. Crossref
-
Chambers Andrea M., Lupo Kyle B., Matosevic Sandro, Tumor Microenvironment-Induced Immunometabolic Reprogramming of Natural Killer Cells, Frontiers in Immunology, 9, 2018. Crossref
-
Alfonsi Romina, Grassi Ludovica, Signore Michele, Bonci Désirée, The Double Face of Exosome-Carried MicroRNAs in Cancer Immunomodulation, International Journal of Molecular Sciences, 19, 4, 2018. Crossref
-
Zhang Jieying, Shi Zhaopeng, Xu Xiang, Yu Zuoren, Mi Jun, The influence of microenvironment on tumor immunotherapy, The FEBS Journal, 286, 21, 2019. Crossref
-
Andersen Mads Hald, Becker Jürgen C., thor Straten Per, Tumor-Produced Immune Regulating Factors, in The Tumor Immunoenvironment, 2013. Crossref
-
Hasmim Meriem, Messai Yosra, Terry Stéphane, Janji Bassam, Noman Muhammad Zaeem, Chouaib Salem, Hypoxia: A Formidable Saboteur of the Anti-tumor Response, in Resistance of Cancer Cells to CTL-Mediated Immunotherapy, 7, 2015. Crossref
-
Kaspler Pavel, Mandel Arkady, Dumoulin-White Roger, Roufaiel Mark, Anticancer Photodynamic Therapy Using Ruthenium(II) and Os(II)-Based Complexes as Photosensitizers, in Tumor Progression and Metastasis, 2020. Crossref
-
Shin Min Hwa, Kim Junghee, Lim Siyoung A., Kim Jungwon, Kim Seong-Jin, Lee Kyung-Mi, NK Cell-Based Immunotherapies in Cancer, Immune Network, 20, 2, 2020. Crossref
-
Tung Jai-Nien, Lin Po-Lin, Wang Yao-Chen, Wu De-Wei, Chen Chi-Yi, Lee Huei, PD-L1 confers resistance to EGFR mutation-independent tyrosine kinase inhibitors in non-small cell lung cancer via upregulation of YAP1 expression, Oncotarget, 9, 4, 2018. Crossref
-
Huang Wen-Wen, Zhu Wen-Zhi, Mu Dong-Liang, Ji Xin-Qiang, Li Xue-Ying, Ma Daqing, Wang Dong-Xin, Intraoperative hypotension is associated with shortened overall survival after lung cancer surgery, BMC Anesthesiology, 20, 1, 2020. Crossref
-
Li Yuanjing , Xu Shengxin , Cai Ming , PO2‑based biodosimetry evaluation using an EPR technique acts as a sensitive index for chemotherapy, Oncology Letters, 2018. Crossref
-
Glaspy John, Disorders of Blood Cell Production in Clinical Oncology, in Abeloff's Clinical Oncology, 2014. Crossref
-
Chouaib Salem, Au carrefour du cancer, Bulletin du Cancer, 100, 6, 2013. Crossref
-
Xu Yuanyi , Jin Xiu , Huang Yunning , Wang Juan , Wang Xiaofei , Wang Honghong , Dextran sulfate inhibition on human gastric cancer cells invasion, migration and epithelial‑mesenchymal transformation, Oncology Letters, 2018. Crossref
-
Kim KyeongJin, Yang Wen-Hao, Jung Youn-Sang, Cha Jong-ho, A new aspect of an old friend: the beneficial effect of metformin on anti-tumor immunity, BMB Reports, 53, 10, 2020. Crossref
-
Arnaiz Esther, Miar Ana, Dias Junior Antonio Gregorio, Prasad Naveen, Schulze Ulrike, Waithe Dominic, Nathan James A., Rehwinkel Jan, Harris Adrian L., Hypoxia Regulates Endogenous Double-Stranded RNA Production via Reduced Mitochondrial DNA Transcription, Frontiers in Oncology, 11, 2021. Crossref
-
Godlewski Jakub, Farhath Mohamed, Ricklefs Franz L., Passaro Carmela, Kiel Klaudia, Nakashima Hiroshi, Chiocca E. Antonio, Bronisz Agnieszka, Oncolytic Virus Therapy Alters the Secretome of Targeted Glioblastoma Cells, Cancers, 13, 6, 2021. Crossref
-
Papademetrio Daniela L., Garcia María Noé, Grasso Daniel, Alvarez Élida, Autophagy-Mediated Exosomes as Immunomodulators of Natural Killer Cells in Pancreatic Cancer Microenvironment, Frontiers in Oncology, 10, 2021. Crossref
-
Ma Jiakang, Lin Xiaoyan, Wang Xueting, Min Qingqing, Wang Tonglian, Tang Chaozhi, Reconstruction and Analysis of the Immune-Related LINC00987/A2M Axis in Lung Adenocarcinoma, Frontiers in Molecular Biosciences, 8, 2021. Crossref
-
Noman Muhammad Zaeem, Janji Bassam, Hu Shijun, Wu Joseph C., Martelli Fabio, Bronte Vincenzo, Chouaib Salem, Tumor-Promoting Effects of Myeloid-Derived Suppressor Cells Are Potentiated by Hypoxia-Induced Expression of miR-210, Cancer Research, 75, 18, 2015. Crossref
-
Nie Chenyu, Qin Haixia, Zhang Li, Saladi Srinivas, Identification and validation of a prognostic signature related to hypoxic tumor microenvironment in cervical cancer, PLOS ONE, 17, 6, 2022. Crossref
-
Ferracin Manuela, Broseghini Elisabetta, Dika Emi, Pathophysiology roles and translational opportunities of miRNAs in cutaneous melanoma, in MicroRNA in Human Malignancies, 2022. Crossref
-
Chouaib S, Noman M Z, Kosmatopoulos K, Curran M A, Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer, Oncogene, 36, 4, 2017. Crossref
-
Bhattacharya S, HuangFu W-C, Dong G, Qian J, Baker D P, Karar J, Koumenis C, Diehl J A, Fuchs S Y, Anti-tumorigenic effects of Type 1 interferon are subdued by integrated stress responses, Oncogene, 32, 36, 2013. Crossref
-
Raj Deepak, Aicher Alexandra, Heeschen Christopher, Concise Review: Stem Cells in Pancreatic Cancer: From Concept to Translation, Stem Cells, 33, 10, 2015. Crossref
-
Messai Yosra, Noman Muhammad Zaeem, Hasmim Meriem, Janji Bassam, Tittarelli Andrés, Boutet Marie, Baud Véronique, Viry Elodie, Billot Katy, Nanbakhsh Arash, Ben Safta Thouraya, Richon Catherine, Ferlicot Sophie, Donnadieu Emmanuel, Couve Sophie, Gardie Betty, Orlanducci Florence, Albiges Laurence, Thiery Jerome, Olive Daniel, Escudier Bernard, Chouaib Salem, ITPR1 Protects Renal Cancer Cells against Natural Killer Cells by Inducing Autophagy, Cancer Research, 74, 23, 2014. Crossref
-
Niknam Malikeh Rad, Attari Farnoosh, The Potential Applications of Stem Cells for Cancer Treatment, Current Stem Cell Research & Therapy, 17, 1, 2022. Crossref
-
Chen Ivy X., Chauhan Vikash P., Posada Jessica, Ng Mei R., Wu Michelle W., Adstamongkonkul Pichet, Huang Peigen, Lindeman Neal, Langer Robert, Jain Rakesh K., Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer, Proceedings of the National Academy of Sciences, 116, 10, 2019. Crossref
-
Ghosh Sadashib, Paul Arkoprovo, Sen Ellora, Tumor Necrosis Factor Alpha-Induced Hypoxia-Inducible Factor 1α–β-Catenin Axis Regulates Major Histocompatibility Complex Class I Gene Activation through Chromatin Remodeling, Molecular and Cellular Biology, 33, 14, 2013. Crossref
-
Noman Muhammad Zaeem, Buart Stéphanie, Romero Pedro, Ketari Sami, Janji Bassam, Mari Bernard, Mami-Chouaib Fathia, Chouaib Salem, Hypoxia-Inducible miR-210 Regulates the Susceptibility of Tumor Cells to Lysis by Cytotoxic T Cells, Cancer Research, 72, 18, 2012. Crossref
-
Ray Suman Kumar, Mukherjee Sukhes, Directing Hypoxic Tumor Microenvironment and HIF to Illuminate Cancer Immunotherapy's Existing Prospects and Challenges in Drug Targets, Current Drug Targets, 23, 5, 2022. Crossref
-
Villarroya-Beltri Carolina, Baixauli Francesc, Gutiérrez-Vázquez Cristina, Sánchez-Madrid Francisco, Mittelbrunn María, Sorting it out: Regulation of exosome loading, Seminars in Cancer Biology, 28, 2014. Crossref
-
Yuan Hang, Chen Bingchen, Chai Rui, Gong Wenjing, Wan Ziang, Zheng Boan, Hu Xinye, Guo Yang, Gao Shan, Dai Qiaoqiong, Yu Peng, Tu Shiliang, Loss of exosomal micro-RNA-200b-3p from hypoxia cancer-associated fibroblasts reduces sensitivity to 5-flourouracil in colorectal cancer through targeting high-mobility group box 3, Frontiers in Oncology, 12, 2022. Crossref
-
Zhang Shaolong, Zhou Jingping, Shang Pengzhao, Zhao Guomeng, Wang Anlei, Mao Jinlei, Tao Yuhang, Chen Ziyi, Wang Xuehao, Guo Changying, SET/PP2A signaling regulates macrophage positioning in hypoxic tumor regions by amplifying chemotactic responses, Experimental & Molecular Medicine, 54, 10, 2022. Crossref