Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Critical Reviews™ in Immunology
Factor de Impacto: 1.404 Factor de Impacto de 5 años: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472

Volumes:
Volumen 40, 2020 Volumen 39, 2019 Volumen 38, 2018 Volumen 37, 2017 Volumen 36, 2016 Volumen 35, 2015 Volumen 34, 2014 Volumen 33, 2013 Volumen 32, 2012 Volumen 31, 2011 Volumen 30, 2010 Volumen 29, 2009 Volumen 28, 2008 Volumen 27, 2007 Volumen 26, 2006 Volumen 25, 2005 Volumen 24, 2004 Volumen 23, 2003 Volumen 22, 2002 Volumen 21, 2001 Volumen 20, 2000 Volumen 19, 1999 Volumen 18, 1998 Volumen 17, 1997 Volumen 16, 1996 Volumen 15, 1995 Volumen 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v16.i3.20
pages 251-274

Structural Aspects of Signal Transduction in B-Cells

Mauno Vihinen
Department of Biosciences, Division of Biochemistry, P.O. Box 56, FIN-00014 University of Helsinki, Finland
C. I. Edward Smith
Center for BioTechnology, Karolinska Institute, Department of Bioscience at NOVUM. S-14157 Huddinge, Sweden, and Department of Clinical Immunology, Karolinska Institute at Huddinge Hospital, S-14186 Huddinge, Sweden

SINOPSIS

Signal transduction in hematopoietic cells is a highly specific process. The stimulation of B cell receptor following antigen binding triggers, as a first step, phosphorylation of the cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). Src family tyrosine kinases Blk, Fyn, Lck, and Lyn as well as spleen kinase, Syk, are activated to transmit the signal further. In this review the signaling events are discussed in structural terms. The factors related to B cell maturation and their targeted mutations are reviewed. During the last 2 years plenty of structural information concerning signaling molecules in B cells has been obtained by using X-ray crystallography, NMR spectroscopy, molecular modeling, and mutational analysis. The molecules discussed include Src family kinases, Syk, Grb2 adaptor protein, and Tec family kinases Bmx and Btk. The structure, function, and interactions of these signaling compounds are described in atomic detail.


Articles with similar content:

Immune Function of C1q and Its Modulators CD91 and CD93
Critical Reviews™ in Immunology, Vol.25, 2005, issue 4
Joanna Tarr, Paul Eggleton
Protein Kinase C Control of Gene Expression
Critical Reviews™ in Eukaryotic Gene Expression, Vol.11, 2001, issue 1-3
Carlo Ventura, Margherita Maioli
Human TCR as Antigen: Homologies and Potentially Cross-Reactive HLA-DR2-Restricted Epitopes Within the AV and BV CDR2 Loops
Critical Reviews™ in Immunology, Vol.20, 2000, issue 1
Arthur A. Vandenbark, Halina Offner, Abigail Buenafe, David Barnes, Gregory G. Burrows, Sandra Law, Yuan K. Chou, Tom Finn, Nicole Culbertson
Role and Modulation of G Protein-Coupled Receptor Signaling in Inflammatory Processes
Critical Reviews™ in Immunology, Vol.22, 2002, issue 2
Maria Stella Lombardi, Annemieke Kavelaars, Cobi J. Heijnen
mTOR Signaling in Cancer Cell Motility and Tumor Metastasis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.20, 2010, issue 1
Hongyu Zhou, Shile Huang