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Critical Reviews™ in Immunology
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ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v20.i6.30
6 pages

Expression of Inhibitory Receptors for MHC Class I Molecules on T Cells

Bertrand Huard
Laboratory of Dermatology 5.222, Geneva University Medical Center, 1, rue Michel-Servet, CH-1211 Geneva 4, Switzerland

SINOPSIS

Inhibitory receptors (IRs) specific for MHC class I molecules and originally described on natural killer (NK) cells are also expressed on a fraction of peripheral T cells. The presence of these receptors on T cells is poorly understood. In this review, the different antigen specificities described to date for IR+ T cells and the expression pattern of these receptors on T cells are analyzed. This analysis indicates that the population of T cells defined by IR expression is heterogeneous and that different IRs (or families of IRs) may play different roles in T-cell biology.


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