Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Critical Reviews™ in Immunology
Factor de Impacto: 1.404 Factor de Impacto de 5 años: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472

Volumes:
Volumen 40, 2020 Volumen 39, 2019 Volumen 38, 2018 Volumen 37, 2017 Volumen 36, 2016 Volumen 35, 2015 Volumen 34, 2014 Volumen 33, 2013 Volumen 32, 2012 Volumen 31, 2011 Volumen 30, 2010 Volumen 29, 2009 Volumen 28, 2008 Volumen 27, 2007 Volumen 26, 2006 Volumen 25, 2005 Volumen 24, 2004 Volumen 23, 2003 Volumen 22, 2002 Volumen 21, 2001 Volumen 20, 2000 Volumen 19, 1999 Volumen 18, 1998 Volumen 17, 1997 Volumen 16, 1996 Volumen 15, 1995 Volumen 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v23.i12.10
13 pages

Role of Peroxisome Proliferator-Activated Receptor g and Its Ligands in the Control of Immune Responses

Alessio Nencioni
Department of Internal Medicine, University of Genova, 16132 Genova, Italy; and Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
Sebastian Wesselborg
Department of Internal Medicine I, University of Tubingen, Tubingen, Germany
Peter Brossart
Department of Hematology, Oncology and Immunology, University of Tübingen, Otfried Muller Str. 10; D-72076 Tübingen, Germany

SINOPSIS

To ensure that efficient immune responses against dangerous antigens are raised while tolerance to self molecules is preserved, the immune system tightly regulates activation and survival of its cellular compartments through mechanisms only partially characterized. In this context, recent evidence indicates a role in immunity of the nuclear receptor PPAR-g, which is upregulated in activated lymphocytes and in dendritic cells. Preliminary in vitro studies indicate that PPAR-g activation profoundly alters the immune properties of these cells, usually leading to the inhibition of immune responses. Naturally occurring PPAR-g ligands include the cyclopentenone prostaglandins of the J series, which are present in bone marrow, thymus, and secondary lymphatic tissues. The levels of these metabolites are increased in inflamed tissues, where they exert strong anti-inflammatory effects leading to resolution of inflammation and wound healing. Cyclopentenone prostaglandins activate both PPAR-g–dependent and PPAR-g–independent pathways, possess intrinsic proapoptotic potential and are direct inhibitors of NF-kB signaling. The relevance of these effects in vivo still awaits proper evaluation in humans. Some of the newly described regulatory pathways might eventually be exploited in the treatment of immune diseases by means of PPAR-g ligands, such as thiazolidinediones or prostaglandins.


Articles with similar content:

The Role of Nitric Oxide and Cyclooxygenase-2 in Attenuating Apoptosis
Journal of Environmental Pathology, Toxicology and Oncology, Vol.21, 2002, issue 2
Andreas von Knethen, Bernhard Brune
Effects of Yakuchinone A and Yakuchinone В on the Phorbol Ester-Induced Expression of COX-2 and iNOS and Activation of NF-kB in Mouse Skin
Journal of Environmental Pathology, Toxicology and Oncology, Vol.21, 2002, issue 2
Young-Joon Surh, Ok Hee Kim, Jee-Young Kang, Hoil Kang, Kyung-Soo Chun
Estrogen Receptor Action
Critical Reviews™ in Eukaryotic Gene Expression, Vol.12, 2002, issue 4
Jan-Ake Gustafsson, Stefan Nilsson
Role of anb3 Integrin Receptor in the Invasive Potential of Human Cervical Cancer (SiHa) Cells
Journal of Environmental Pathology, Toxicology and Oncology, Vol.20, 2001, issue 3
Nibedita Chattopadhyay, Amitava Chatterjee
Complex Smad-Dependent Transcriptional Responses in Vertebrate Development and Human Disease
Critical Reviews™ in Eukaryotic Gene Expression, Vol.12, 2002, issue 2
Leo A. van Grunsven, Danny Huylebroeck, Kristin Verschueren