Publicado 6 números por año
ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472
Indexed in
Cell Surface Glycans: The Why and How of Their Functionality as Biochemical Signals in Lectin-Mediated Information Transfer
SINOPSIS
Calculations of the coding capacity of biomolecules come up with the striking result that carbohydrates excel nucleotides and amino acids by far in this respect. Consequently, glycans are ideally suited to equip cell surfaces with a maximum of signals in a minimum of space and form the cellular glycome. The ensuing concept of the sugar code interprets glycans as a platform for encoding messages and shifts in the glycome as a means to swiftly add/remove signals. Next, it implies the presence of effectors that read the signals in situ. Fittingly, recent work on natural decoding devices in mammals (endogenous lectins) has revealed not only their presence but a level of complexity that matches the structural diversity of glycans. The emerging importance of lectinligand interaction in immune regulation calls for an introduction to this concept for nonspecialists. This primer to the fundamentals of the sugar code, with telling examples from the realm of immunology, also illustrates the strategic and hitherto unsuspected fine-tuning between glycan structure and lectin design/expression.
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Parsonage Greg, Trebilcock Emily, Toscano Marta A, Bianco Germán A, Ilarregui Juan M, Buckley Christopher D, Rabinovich Gabriel A, Roles of galectins in chronic inflammatory microenvironments, Future Rheumatology, 1, 4, 2006. Crossref
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Sarkar Anita, Pérez Serge, PolySac3DB: an annotated data base of 3 dimensional structures of polysaccharides, BMC Bioinformatics, 13, 1, 2012. Crossref
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Pál Zsuzsanna, Antal Péter, Srivastava Sanjeev Kumar, Hullám Gábor, Semsei Ágnes F., Gál János, Svébis Mihály, Soós Györgyi, Szalai Csaba, André Sabine, Gordeeva Elena, Nagy György, Kaltner Herbert, Bovin Nicolai V., Molnár Mária Judit, Falus András, Gabius Hans-Joachim, Buzás Edit Irén, Non-synonymous single nucleotide polymorphisms in genes for immunoregulatory galectins: Association of galectin-8 (F19Y) occurrence with autoimmune diseases in a Caucasian population, Biochimica et Biophysica Acta (BBA) - General Subjects, 1820, 10, 2012. Crossref
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Ledeen Robert W., Wu Gusheng, André Sabine, Bleich David, Huet Guillemette, Kaltner Herbert, Kopitz Jürgen, Gabius Hans-Joachim, Beyond glycoproteins as galectin counterreceptors: tumor-effector T cell growth control via ganglioside GM1, Annals of the New York Academy of Sciences, 1253, 1, 2012. Crossref
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Sarter K., Janko C., Andre S., Munoz L. E., Schorn C., Winkler S., Rech J., Kaltner H., Lorenz H.-M., Schiller M., Andreoli L., Manfredi A. A., Isenberg D. A., Schett G., Herrmann M., Gabius H.-J., Autoantibodies against galectins are associated with antiphospholipid syndrome in patients with systemic lupus erythematosus, Glycobiology, 23, 1, 2013. Crossref
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Ulmer Tricia A., Keeler Vicki, André Sabine, Gabius Hans-Joachim, Loh Lambert, Laferté Suzanne, The tumor-associated antigen 90K/Mac-2-binding protein secreted by human colon carcinoma cells enhances extracellular levels of promatrilysin and is a novel substrate of matrix metalloproteinases-2, -7 (matrilysin) and -9: Implications of proteolytic cleavage, Biochimica et Biophysica Acta (BBA) - General Subjects, 1800, 3, 2010. Crossref
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André Sabine, Cañada F. Javier, Shiao Tze Chieh, Largartera Laura, Diercks Tammo, Bergeron-Brlek Milan, el Biari Khouzaima, Papadopoulos Alex, Ribeiro Joao P., Touaibia Mohamed, Solís Dolores, Menéndez Margarita, Jiménez-Barbero Jesús, Roy René, Gabius Hans-Joachim, Fluorinated Carbohydrates as Lectin Ligands: Biorelevant Sensors with Capacity to Monitor Anomer Affinity in 19F-NMR-Based Inhibitor Screening, European Journal of Organic Chemistry, 2012, 23, 2012. Crossref
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Toscano Marta A, Bianco Germán A, Ilarregui Juan M, Croci Diego O, Correale Jorge, Hernandez Joseph D, Zwirner Norberto W, Poirier Francoise, Riley Eleanor M, Baum Linda G, Rabinovich Gabriel A, Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death, Nature Immunology, 8, 8, 2007. Crossref
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Alge-Priglinger Claudia S., André Sabine, Schoeffl Harald, Kampik Anselm, Strauss Rupert W., Kernt Marcus, Gabius Hans-Joachim, Priglinger Siegfried G., Negative regulation of RPE cell attachment by carbohydrate-dependent cell surface binding of galectin-3 and inhibition of the ERK–MAPK pathway, Biochimie, 93, 3, 2011. Crossref
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Lacina L., Smetana K., Dvořánková B., Pytlík R., Kideryová L., Kučerová L., Plzáková Z., Štork J., Gabius H-J., André S., Stromal fibroblasts from basal cell carcinoma affect phenotype of normal keratinocytes, British Journal of Dermatology, 156, 5, 2007. Crossref
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Gómez-García Marta, Benito Juan M., Gutiérrez-Gallego Ricardo, Maestre Alfredo, Mellet Carmen Ortiz, Fernández José M. García, Blanco José L. Jiménez, Comparative studies on lectin–carbohydrate interactions in low and high density homo- and heteroglycoclusters, Organic & Biomolecular Chemistry, 8, 8, 2010. Crossref
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Lohr Michaela, Kaltner Herbert, Lensch Martin, André Sabine, Sinowatz Fred, Gabius Hans-Joachim, Cell-type-specific expression of murine multifunctional galectin-3 and its association with follicular atresia/luteolysis in contrast to pro-apoptotic galectins-1 and -7, Histochemistry and Cell Biology, 130, 3, 2008. Crossref
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Grant Oliver C, Woods Robert J, Recent advances in employing molecular modelling to determine the specificity of glycan-binding proteins, Current Opinion in Structural Biology, 28, 2014. Crossref
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Strino Francesco, Lii Jenn-Huei, Gabius Hans-Joachim, Nyholm Per-Georg, Conformational analysis of thioglycoside derivatives of histo-blood group ABH antigens using an ab initio-derived reparameterization of MM4: implications for design of non-hydrolysable mimetics, Journal of Computer-Aided Molecular Design, 23, 12, 2009. Crossref
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Patsos G., Andre S., Roeckel N., Gromes R., Gebert J., Kopitz J., Gabius H.-J., Compensation of loss of protein function in microsatellite-unstable colon cancer cells (HCT116): A gene-dependent effect on the cell surface glycan profile, Glycobiology, 19, 7, 2009. Crossref
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Hildebrandt Herbert, Mühlenhoff Martina, Weinhold Birgit, Gerardy-Schahn Rita, Dissecting polysialic acid and NCAM functions in brain development, Journal of Neurochemistry, 103, s1, 2007. Crossref
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Beer Alexandra, André Sabine, Kaltner Herbert, Lensch Martin, Franz Sandra, Sarter Kerstin, Schulze Connie, Gaipl Udo S., Kern Peter, Herrmann Martin, Gabius Hans-Joachim, Human galectins as sensors for apoptosis/necrosis-associated surface changes of granulocytes and lymphocytes, Cytometry Part A, 73A, 2, 2008. Crossref
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Lohr M., Kaltner H., Schwartz-Albiez R., Sinowatz F., Gabius H.-J., Towards Functional Glycomics by Lectin Histochemistry: Strategic Probe Selection to Monitor Core and Branch-end Substitutions and Detection of Cell-type and Regional Selectivity in Adult Mouse Testis and Epididymis, Anatomia, Histologia, Embryologia, 39, 6, 2010. Crossref
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Frol’ová Lenka, Smetana Karel, Borovská Dana, Kitanovičová Andrea, Klimešová Klára, Janatková Ivana, Malíčková Karin, Lukáš Milan, Drastich Pavel, Beneš Zdeněk, Tučková Ludmila, Manning Joachim C., André Sabine, Gabius Hans-Joachim, Tlaskalová-Hogenová Helena, Detection of galectin-3 in patients with inflammatory bowel diseases: new serum marker of active forms of IBD?, Inflammation Research, 58, 8, 2009. Crossref
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Jiménez-Barbero Jesús, Dragoni Elisa, Venturi Chiara, Nannucci Federico, Ardá Ana, Fontanella Marco, André Sabine, Cañada Francisco Javier, Gabius Hans-Joachim, Nativi Cristina, α-O-Linked Glycopeptide Mimetics: Synthesis, Conformation Analysis, and Interactions with Viscumin, a Galactoside-Binding Model Lectin, Chemistry - A European Journal, 15, 40, 2009. Crossref
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Paclik Daniela, Berndt Uta, Guzy Claudia, Dankof Anja, Danese Silvio, Holzloehner Pamela, Rosewicz Stefan, Wiedenmann Bertram, Wittig Bianca M., Dignass Axel U., Sturm Andreas, Galectin-2 induces apoptosis of lamina propria T lymphocytes and ameliorates acute and chronic experimental colitis in mice, Journal of Molecular Medicine, 86, 12, 2008. Crossref
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Strino Francesco, Lii Jenn-Huei, Koppisetty Chaitanya A. K., Nyholm Per-Georg, Gabius Hans-Joachim, Selenoglycosides in silico: ab initio-derived reparameterization of MM4, conformational analysis using histo-blood group ABH antigens and lectin docking as indication for potential of bioactivity, Journal of Computer-Aided Molecular Design, 24, 12, 2010. Crossref
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Diercks Tammo, Ribeiro João P., Cañada F. Javier, André Sabine, Jiménez-Barbero Jesús, Gabius Hans-Joachim, Fluorinated Carbohydrates as Lectin Ligands: Versatile Sensors in19F-Detected Saturation Transfer Difference NMR Spectroscopy, Chemistry - A European Journal, 15, 23, 2009. Crossref
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Patsos Georgios, Hebbe-Viton Virginie, Robbe-Masselot Catherine, Masselot David, Martin Raul San, Greenwood Rosemary, Paraskeva Christos, Klein Andreas, Graessmann Monika, Michalski Jean Claude, Gallagher Timothy, Corfield Anthony, O-Glycan inhibitors generate aryl-glycans, induce apoptosis and lead to growth inhibition in colorectal cancer cell lines, Glycobiology, 19, 4, 2009. Crossref
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Stechly Laurence, Morelle Willy, Dessein Anne-Frédérique, André Sabine, Grard Georges, Trinel Dave, Dejonghe Marie-José, Leteurtre Emmanuelle, Drobecq Hervé, Trugnan Germain, Gabius Hans Joachim, Huet Guillemette, Galectin-4-Regulated Delivery of Glycoproteins to the Brush Border Membrane of Enterocyte-Like Cells, Traffic, 10, 4, 2009. Crossref
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Kaltner Herbert, Kübler Dieter, López-Merino Lara, Lohr Michaela, Manning Joachim C., Lensch Martin, Seidler Joerg, Lehmann Wolf D., André Sabine, Solís Dolores, Gabius Hans-Joachim, Toward Comprehensive Analysis of the Galectin Network in Chicken: Unique Diversity of Galectin-3 and Comparison of its Localization Profile in Organs of Adult Animals to the Other Four Members of this Lectin Family, The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, 294, 3, 2011. Crossref
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He Lizhong, André Sabine, Garamus Vasil M., Siebert Hans-Christian, Chi Chunyan, Niemeyer Bernd, Gabius Hans-Joachim, Small angle neutron scattering as sensitive tool to detect ligand-dependent shape changes in a plant lectin with β-trefoil folding and their dependence on the nature of the solvent, Glycoconjugate Journal, 26, 1, 2009. Crossref
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André Sabine, Velasco-Torrijos Trinidad, Leyden Rosaria, Gouin Sebastien, Tosin Manuela, Murphy Paul V., Gabius Hans-Joachim, Phenylenediamine-based bivalent glycocyclophanes: synthesis and analysis of the influence of scaffold rigidity and ligand spacing on lectin binding in cell systems with different glycomic profiles, Organic & Biomolecular Chemistry, 7, 22, 2009. Crossref
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Purhonen A. K., Herzig K. H., Gabius H. J., André S., Ketterer S., Matzinger D., Beglinger C., Hildebrand P., Duodenal phytohaemagglutinin (red kidney bean lectin) stimulates gallbladder contraction in humans, Acta Physiologica, 193, 3, 2008. Crossref
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Muñoz F. Javier, Rumbero Ángel, Sinisterra José V., Santos J. Ignacio, André Sabine, Gabius Hans-J., Jiménez-Barbero Jesús, Hernáiz María J., Versatile strategy for the synthesis of biotin-labelled glycans, their immobilization to establish a bioactive surface and interaction studies with a lectin on a biochip, Glycoconjugate Journal, 25, 7, 2008. Crossref
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García-Aparicio Víctor, Sollogoub Matthieu, Blériot Yves, Colliou Virginie, André Sabine, Asensio Juan L., Cañada F. Javier, Gabius Hans-Joachim, Sinaÿ Pierre, Jiménez-Barbero Jesús, The conformation of the C-glycosyl analogue of N-acetyl-lactosamine in the free state and bound to a toxic plant agglutinin and human adhesion/growth-regulatory galectin-1, Carbohydrate Research, 342, 12-13, 2007. Crossref
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Langbein S, Brade J, Badawi J K, Hatzinger M, Kaltner H, Lensch M, Specht K, André S, Brinck U, Alken P, Gabius H-J, Gene-expression signature of adhesion/growth-regulatory tissue lectins (galectins) in transitional cell cancer and its prognostic relevance, Histopathology, 51, 5, 2007. Crossref
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Martín-Pastor Manuel, Vega-Vázquez Marino, De Capua Antonia, Canales Angeles, André Sabine, Gabius Hans-Joachim, Jiménez-Barbero Jesús, Enhanced signal dispersion in saturation transfer difference experiments by conversion to a 1D-STD-homodecoupled spectrum, Journal of Biomolecular NMR, 36, 2, 2006. Crossref
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Park Hyunji, Rosencrantz Ruben R., Elling Lothar, Böker Alexander, Glycopolymer Brushes for Specific Lectin Binding by Controlled Multivalent Presentation ofN-Acetyllactosamine Glycan Oligomers, Macromolecular Rapid Communications, 36, 1, 2015. Crossref
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Szabo P., Dam T. K., Smetana Jr K., Dvořánková B., Kübler D., Brewer C. F., Gabius H.-J., Phosphorylated Human Lectin Galectin-3: Analysis of Ligand Binding by Histochemical Monitoring of Normal/Malignant Squamous Epithelia and by Isothermal Titration Calorimetry, Anatomia, Histologia, Embryologia, 38, 1, 2009. Crossref
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Saussez Sven, Decaestecker Christine, Mahillon Virginie, Cludts Stéphanie, Capouillez Aurélie, Chevalier Dominique, Vet Herbert Kaltner, André Sabine, Toubeau Gérard, Leroy Xavier, Gabius Hans-Joachim, Galectin-3 Upregulation During Tumor Progression in Head and Neck Cancer, The Laryngoscope, 118, 9, 2008. Crossref
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André Sabine, Sansone Francesco, Kaltner Herbert, Casnati Alessandro, Kopitz Jürgen, Gabius Hans‐Joachim, Ungaro Rocco, Calix[n]arene‐Based Glycoclusters: Bioactivity of Thiourea‐Linked Galactose/Lactose Moieties as Inhibitors of Binding of Medically Relevant Lectins to a Glycoprotein and Cell‐Surface Glycoconjugates and Selectivity among Human Adhesion/Growth‐Regulatory Galectins, ChemBioChem, 9, 10, 2008. Crossref
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Edwards Paul, The use of combinatorial chemistry libraries for the discovery of biologically active substances, Drug Discovery Today, 14, 7-8, 2009. Crossref
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André Sabine, Sanchez-Ruderisch Hugo, Nakagawa Hiroaki, Buchholz Malte, Kopitz Jürgen, Forberich Pia, Kemmner Wolfgang, Böck Corina, Deguchi Kisaburo, Detjen Katharia M., Wiedenmann Bertram, von Knebel Doeberitz Magnus, Gress Thomas M., Nishimura Shin-Ichiro, Rosewicz Stefan, Gabius Hans-Joachim, Tumor suppressor p16INK4a − modulator of glycomic profile and galectin-1 expression to increase susceptibility to carbohydrate-dependent induction of anoikis in pancreatic carcinoma cells, FEBS Journal, 274, 13, 2007. Crossref
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Vokhmyanina O. A., Rapoport E. M., Ryzhov I. M., Korchagina E. Yu., Pazynina G. V., Severov V. V., Kaltner H., André S., Gabius H. -J., Bovin N. V., Carbohydrate specificity of chicken and human tandem-repeat-type galectins-8 in composition of cells, Biochemistry (Moscow), 76, 10, 2011. Crossref
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Krzeminski Mickaël, Singh Tanuja, André Sabine, Lensch Martin, Wu Albert M., Bonvin Alexandre M.J.J., Gabius Hans-Joachim, Human galectin-3 (Mac-2 antigen): Defining molecular switches of affinity to natural glycoproteins, structural and dynamic aspects of glycan binding by flexible ligand docking and putative regulatory sequences in the proximal promoter region, Biochimica et Biophysica Acta (BBA) - General Subjects, 1810, 2, 2011. Crossref
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André Sabine, Grandjean Cyrille, Gautier François-Moana, Bernardi Silvia, Sansone Francesco, Gabius Hans-Joachim, Ungaro Rocco, Combining carbohydrate substitutions at bioinspired positions with multivalent presentation towards optimising lectin inhibitors: case study with calixarenes, Chemical Communications, 47, 21, 2011. Crossref
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Van de Wouwer Marlies, André Sabine, Gabius Hans-J., Villalobo Antonio, Nitric oxide changes distinct aspects of the glycophenotype of human neuroblastoma NB69 cells, Nitric Oxide, 24, 2, 2011. Crossref
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Kübler Dieter, Hung Chien-Wen, Dam Tarun K., Kopitz Jürgen, André Sabine, Kaltner Herbert, Lohr Michaela, Manning Joachim C., He Lizhong, Wang Hui, Middelberg Anton, Brewer C. Fred, Reed Jennifer, Lehmann Wolf-Dieter, Gabius Hans-Joachim, Phosphorylated human galectin-3: Facile large-scale preparation of active lectin and detection of structural changes by CD spectroscopy, Biochimica et Biophysica Acta (BBA) - General Subjects, 1780, 4, 2008. Crossref
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Barrès Céline, Blanc Lionel, Bette-Bobillo Pascale, André Sabine, Mamoun Robert, Gabius Hans-Joachim, Vidal Michel, Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages, Blood, 115, 3, 2010. Crossref
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André Sabine, Renaudet Olivier, Bossu Isabelle, Dumy Pascal, Gabius Hans-Joachim, Cyclic neoglycodecapeptides: how to increase their inhibitory activity and selectivity on lectin/toxin binding to a glycoprotein and cells, Journal of Peptide Science, 17, 6, 2011. Crossref
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Habermann Felix A., André Sabine, Kaltner Herbert, Kübler Dieter, Sinowatz Fred, Gabius Hans-Joachim, Galectins as tools for glycan mapping in histology: comparison of their binding profiles to the bovine zona pellucida by confocal laser scanning microscopy, Histochemistry and Cell Biology, 135, 6, 2011. Crossref
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André Sabine, Maljaars C. Elizabeth P., Halkes Koen M., Gabius Hans-Joachim, Kamerling Johannis P., Discovery of galectin ligands in fully randomized combinatorial one-bead-one-compound (glyco)peptide libraries, Bioorganic & Medicinal Chemistry Letters, 17, 3, 2007. Crossref
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Perić-Hassler Lovorka, Hansen Halvor S., Baron Riccardo, Hünenberger Philippe H., Conformational properties of glucose-based disaccharides investigated using molecular dynamics simulations with local elevation umbrella sampling, Carbohydrate Research, 345, 12, 2010. Crossref
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Toscano Marta A., Ilarregui Juan M., Bianco Germán A., Campagna Leonardo, Croci Diego O., Salatino Mariana, Rabinovich Gabriel A., Dissecting the pathophysiologic role of endogenous lectins: Glycan-binding proteins with cytokine-like activity?, Cytokine & Growth Factor Reviews, 18, 1-2, 2007. Crossref
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Lensch Martin, Lohr Michaela, Russwurm Roland, Vidal Michel, Kaltner Herbert, André Sabine, Gabius Hans-Joachim, Unique sequence and expression profiles of rat galectins-5 and -9 as a result of species-specific gene divergence, The International Journal of Biochemistry & Cell Biology, 38, 10, 2006. Crossref
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Sanchez-Ruderisch H, Detjen K M, Welzel M, André S, Fischer C, Gabius H-J, Rosewicz S, Galectin-1 sensitizes carcinoma cells to anoikis via the fibronectin receptor α5β1-integrin, Cell Death & Differentiation, 18, 5, 2011. Crossref
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Garron M.-L., Cygler M., Structural and mechanistic classification of uronic acid-containing polysaccharide lyases, Glycobiology, 20, 12, 2010. Crossref
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Dam T.K., Brewer C.F., Fundamentals of Lectin–Carbohydrate Interactions, in Comprehensive Glycoscience, 2007. Crossref
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Martín-Santamaría Sonsoles, André Sabine, Buzamet Eliza, Caraballo Rémi, Fernández-Cureses Gloria, Morando Maria, Ribeiro João P., Ramírez-Gualito Karla, de Pascual-Teresa Beatriz, Cañada F. Javier, Menéndez Margarita, Ramström Olof, Jiménez-Barbero Jesús, Solís Dolores, Gabius Hans-Joachim, Symmetric dithiodigalactoside: strategic combination of binding studies and detection of selectivity between a plant toxin and human lectins, Organic & Biomolecular Chemistry, 9, 15, 2011. Crossref
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Miller Michelle C, Ribeiro João P, Roldós Virginia, Martín-Santamaría Sonsoles, Cañada F Javier, Nesmelova Irina A, André Sabine, Pang Mabel, Klyosov Anatole A, Baum Linda G, Jiménez-Barbero Jesús, Gabius Hans-Joachim, Mayo Kevin H, Structural aspects of binding of α-linked digalactosides to human galectin-1, Glycobiology, 21, 12, 2011. Crossref
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Widmalm G., General NMR Spectroscopy of Carbohydrates and Conformational Analysis in Solution, in Comprehensive Glycoscience, 2007. Crossref
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Pandey Gunjan, Fatma Tasneem, Cowsik Sudha M., Komath Sneha Sudha, Specific interaction of jacalin with phycocyanin, a fluorescent phycobiliprotein, Journal of Photochemistry and Photobiology B: Biology, 97, 2, 2009. Crossref
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Roldós Virginia, Cañada F. Javier, Jiménez-Barbero Jesús, Carbohydrate-Protein Interactions: A 3D View by NMR, ChemBioChem, 12, 7, 2011. Crossref
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Maljaars C. Elizabeth P., André Sabine, Halkes Koen M., Gabius Hans-Joachim, Kamerling Johannis P., Assessing the inhibitory potency of galectin ligands identified from combinatorial (glyco)peptide libraries using surface plasmon resonance spectroscopy, Analytical Biochemistry, 378, 2, 2008. Crossref
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Sanchez-Ruderisch Hugo, Fischer Christian, Detjen Katharina M., Welzel Martina, Wimmel Anja, Manning Joachim C., André Sabine, Gabius Hans-Joachim, Tumor suppressor p16INK4a: Downregulation of galectin-3, an endogenous competitor of the pro-anoikis effector galectin-1, in a pancreatic carcinoma model, FEBS Journal, 277, 17, 2010. Crossref
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Sarter Kerstin, André Sabine, Kaltner Herbert, Lensch Martin, Schulze Connie, Urbonaviciute Vilma, Schett Georg, Herrmann Martin, Gabius Hans-Joachim, Detection and chromatographic removal of lipopolysaccharide in preparations of multifunctional galectins, Biochemical and Biophysical Research Communications, 379, 1, 2009. Crossref
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Buzás Edit I., Buzás Edit I., György Bence, Buzás Edit I., György Bence, Pásztói Mária, Jelinek Ivett, Falus András, Gabius Hans-Joachim, Carbohydrate recognition systems in autoimmunity, Autoimmunity, 39, 8, 2006. Crossref
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Lacina Lukas, Dvořánkova Barbora, Smetana Karel, Chovanec Martin, Plzák Jan, Tachezy Ruth, Kideryová Linda, Kučerová L., Čada Zdenek, Bouček Jan, Kodet R., André S., Gabius Hans-Joachim, Marker profiling of normal keratinocytes identifies the stroma from squamous cell carcinoma of the oral cavity as a modulatory microenvironment in co-culture, International Journal of Radiation Biology, 83, 11-12, 2007. Crossref
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Kim Seung-Hyun, Behnes Michael, Natale Michele, Hoffmann Julia, Reckord Nadine, Hoffmann Ursula, Budjan Johannes, Henzler Thomas, Papavassiliu Theano, Borggrefe Martin, Bertsch Thomas, Akin Ibrahim, Galectin-3 Reflects Mitral Annular Plane Systolic Excursion Being Assessed by Cardiovascular Magnetic Resonance Imaging, Disease Markers, 2016, 2016. Crossref
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Mizuhashi Koji, Chaya Taro, Kanamoto Takashi, Omori Yoshihiro, Furukawa Takahisa, Malaval Luc, Obif, a Transmembrane Protein, Is Required for Bone Mineralization and Spermatogenesis in Mice, PLOS ONE, 10, 7, 2015. Crossref
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Lindhorst Thisbe, Oligosaccharides and Glycoco njugates in Reco gnition Processes, in Carbohydrate-Modifying Biocatalysts, 2011. Crossref
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Venier Paola, Varotto Laura, Rosani Umberto, Millino Caterina, Celegato Barbara, Bernante Filippo, Lanfranchi Gerolamo, Novoa Beatriz, Roch Philippe, Figueras Antonio, Pallavicini Alberto, Insights into the innate immunity of the Mediterranean mussel Mytilus galloprovincialis, BMC Genomics, 12, 1, 2011. Crossref
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Wu Albert M., Singh Tanuja, Wu June H., Lensch Martin, André Sabine, Gabius Hans-Joachim, Interaction profile of galectin-5 with free saccharides and mammalian glycoproteins: probing its fine specificity and the effect of naturally clustered ligand presentation, Glycobiology, 16, 6, 2006. Crossref
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Hershkovitz Oren, Jarahian Mostafa, Zilka Alon, Bar-Ilan Ahuva, Landau Guy, Jivov Sergey, Tekoah Yoram, Glicklis Rachel, Gallagher John T., Hoffmann Sabrina C., Zer Hagit, Mandelboim Ofer, Watzl Carsten, Momburg Frank, Porgador Angel, Altered glycosylation of recombinant NKp30 hampers binding to heparan sulfate: a lesson for the use of recombinant immunoreceptors as an immunological tool, Glycobiology, 18, 1, 2008. Crossref
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Xie Yixuan, Peng Chao, Gao Yunyi, Liu Xiaohong, Liu Tianbo, Joy Abraham, Mannose-based graft polyesters with tunable binding affinity to concanavalin A, Journal of Polymer Science Part A: Polymer Chemistry, 55, 23, 2017. Crossref
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Bernardi Silvia, Yi Dong, He Ning, Casnati Alessandro, Fessner Wolf-Dieter, Sansone Francesco, Complete tetraglycosylation of a calix[4]arene by a chemo-enzymatic approach, Organic & Biomolecular Chemistry, 15, 47, 2017. Crossref
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Wu Albert M., Singh Tanuja, Liu Jia-Hau, Krzeminski Mickael, Russwurm Roland, Siebert Hans-Christian, Bonvin Alexandre M.J.J., André Sabine, Gabius Hans-Joachim, Activity–structure correlations in divergent lectin evolution: fine specificity of chicken galectin CG-14 and computational analysis of flexible ligand docking for CG-14 and the closely related CG-16, Glycobiology, 17, 2, 2007. Crossref
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Liu Yun-He, D'Ambrosio Martin, Liao Tang-dong, Peng Hongmei, Rhaleb Nour-Eddine, Sharma Umesh, André Sabine, Gabius Hans-J., Carretero Oscar A., N-acetyl-seryl-aspartyl-lysyl-proline prevents cardiac remodeling and dysfunction induced by galectin-3, a mammalian adhesion/growth-regulatory lectin, American Journal of Physiology-Heart and Circulatory Physiology, 296, 2, 2009. Crossref
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Böcker Sophia, Elling Lothar, Biotinylated N-Acetyllactosamine- and N,N-Diacetyllactosamine-Based Oligosaccharides as Novel Ligands for Human Galectin-3, Bioengineering, 4, 4, 2017. Crossref
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Chassagnon Irene R., Piper Sarah J., Landsberg Michael J., ABC Toxins: Self-Assembling Nanomachines for the Targeted Cellular Delivery of Bioactive Proteins, in Comprehensive Nanoscience and Nanotechnology, 2019. Crossref
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Hayes Anthony J., Melrose James, Glycosaminoglycan and Proteoglycan Biotherapeutics in Articular Cartilage Protection and Repair Strategies: Novel Approaches to Visco‐supplementation in Orthobiologics, Advanced Therapeutics, 2, 8, 2019. Crossref
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Wang Jianfeng, Lu Zi-Hua, Gabius Hans-Joachim, Rohowsky-Kochan Christine, Ledeen Robert W., Wu Gusheng, Cross-Linking of GM1 Ganglioside by Galectin-1 Mediates Regulatory T Cell Activity Involving TRPC5 Channel Activation: Possible Role in Suppressing Experimental Autoimmune Encephalomyelitis, The Journal of Immunology, 182, 7, 2009. Crossref
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Gabius Hans-Joachim, Animal and Human Lectins, in Antitumor Potential and other Emerging Medicinal Properties of Natural Compounds, 2013. Crossref
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Kiessling Laura L., Young Travis, Gruber Todd D., Mortell Kathleen H., Multivalency in Protein–Carbohydrate Recognition, in Glycoscience, 2008. Crossref
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Rüdiger H., Hänsel R., Gabius H. -J., Pflanzliche Lectine: Vorkommen, Eigenschaften, Analytik und Bewertung ihrer immunmodulatorischen Aktivität, in Pharmakognosie — Phytopharmazie, 2007. Crossref
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Zilka Alon, Mendelson Michal, Rosental Benyamin, Hershkovitz Oren, Porgador Angel, Generating NK Cell Receptor-Fc Chimera Proteins from 293T Cells and Considerations of Appropriate Glycosylation, in Natural Killer Cell Protocols, 612, 2010. Crossref
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Morelle Willy, Stechly Laurence, André Sabine, Seuningen Isabelle Van, Porchet Nicole, Gabius Hans-Joachim, Michalski Jean-Claude, Huet Guillemette, Glycosylation pattern of brush border-associated glycoproteins in enterocyte-like cells: involvement of complex-type N-glycans in apical trafficking, bchm, 390, 7, 2009. Crossref
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Pearson Amanda J., Gallagher Elyssia S., Overview of Characterizing Cancer Glycans with Lectin-Based Analytical Methods, in Cancer Metabolism, 1928, 2019. Crossref
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