Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Critical Reviews™ in Immunology
Factor de Impacto: 1.404 Factor de Impacto de 5 años: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472

Volumen 40, 2020 Volumen 39, 2019 Volumen 38, 2018 Volumen 37, 2017 Volumen 36, 2016 Volumen 35, 2015 Volumen 34, 2014 Volumen 33, 2013 Volumen 32, 2012 Volumen 31, 2011 Volumen 30, 2010 Volumen 29, 2009 Volumen 28, 2008 Volumen 27, 2007 Volumen 26, 2006 Volumen 25, 2005 Volumen 24, 2004 Volumen 23, 2003 Volumen 22, 2002 Volumen 21, 2001 Volumen 20, 2000 Volumen 19, 1999 Volumen 18, 1998 Volumen 17, 1997 Volumen 16, 1996 Volumen 15, 1995 Volumen 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v26.i1.10
pages 1-22

MHC Transfer from APC to T Cells Following Antigen Recognition

Scott A. Wetzel
Division of Biological Sciences and Center for Environmental Health Sciences, The University of Montana, Missoula, MT 59812
David C. Parker
Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR 97239


Recognition of cognate MHC:peptide complexes by T cells leads to large-scale molecular rearrangements resulting in immunological synapse formation at the T cell-antigen-presenting cell (APC) interface. Although the functions of the immunological synapse are not completely understood, a consequence of this event appears to be the intercellular transfer of MHC:peptide complexes, along with other molecules such as CD80, from the APC to the T cell. The expression of APC-derived molecules on the T cell is biologically significant. It has the potential to alter the homing, allow T cells to also act as APC, and may alter the effector functions of the cell. Experimental evidence suggests that intercellular transfer may play a role in the control of an immune response; however, the exact role is unclear. Both potentiation and attenuation of an ongoing response have been postulated. In addition, removal of molecules from APC may be important in controlling homeostatic proliferation, in affinity maturation of T cells, and in maintaining epitope diversity during an immune response. In this review, we highlight recent advances regarding the mechanism of intercellular transfer and focus on the potential biological significance of this event.

Articles with similar content:

Regulation of NK Cell Repertoire and Function in the Liver
Critical Reviews™ in Immunology, Vol.31, 2011, issue 1
Peter D. Krueger, Huihong Qiao, Matthew G. Lassen, Young S. Hahn
Role of the Glucocorticoid-Induced TNFR-Related Protein (GITR)-GITR Ligand Pathway in Innate and Adaptive Immunity
Critical Reviews™ in Immunology, Vol.30, 2010, issue 6
Miyuki Azuma
The Role of Forkhead Box 1 (FOXO1) in the Immune System: Dendritic Cells, T Cells, B Cells, and Hematopoietic Stem Cells
Critical Reviews™ in Immunology, Vol.37, 2017, issue 1
Adriana Alicia Cabrera-Ortega, Daniel Feinberg, Carlos Rossa, Jr., Youde Liang, Dana T. Graves
Human T-Cell Development and Thymic Egress: An Infectious Disease Perspective
Forum on Immunopathological Diseases and Therapeutics, Vol.6, 2015, issue 1-2
Christel H. Uittenbogaart, Rachel S. Resop
Regulatory T-cell Trafficking: From Thymic Development to Tumor-Induced Immune Suppression
Critical Reviews™ in Immunology, Vol.30, 2010, issue 5
Adam Mailloux, M. Rita I. Young