Publicado 6 números por año
ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472
Indexed in
Plasma Cell Formation, Secretion, and Persistence: The Short and the Long of It
SINOPSIS
B cells can be activated by cognate antigen, anti-B-cell receptor antibody, complement receptors, or polyclonal stimulators like lipopolysaccharide; the overall result is a large shift in RNA processing to the secretory-specific form of immunoglobulin (Ig) heavy chain mRNA and an upregulation of Igh mRNA amounts. Associated with this shift is the large-scale induction of Ig protein synthesis and the unfolded protein response to accommodate the massive quantity of secretory Ig that results. Stimulation to secretion also produces major structural accommodations and stress, with extensive generation of endoplasmic reticulum and Golgi as part of the cellular architecture. Reactive oxygen species can lead to either activation or apoptosis based on context and the high or low oxygen tension surrounding the cells. Transcription elongation factor ELL2 plays an important role in the induction of Ig secretory mRNA production, the unfolded protein response, and gene expression during hypoxia. After antigen stimulation, activated B cells from either the marginal zones or follicles can produce short-lived antibody secreting cells; it is not clear whether cells from both locations can become long-lived plasma cells. Autophagy is necessary for plasma cell long-term survival through the elimination of some of the accumulated damage to the ER from producing so much protein. Survival signals from the bone marrow stromal cells also contribute to plasma cell longevity, with BCMA serving a potentially unique survival role. Integrating the various information pathways converging on the plasma cell is crucial to the development of their long-lived, productive immune response.
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Tellier Julie, Shi Wei, Minnich Martina, Liao Yang, Crawford Simon, Smyth Gordon K, Kallies Axel, Busslinger Meinrad, Nutt Stephen L, Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response, Nature Immunology, 17, 3, 2016. Crossref
-
Smith Sage M, RNA polymerases in plasma cells trav-ELL2 the beat of a different drum, World Journal of Immunology, 5, 3, 2015. Crossref
-
Xiao Xiao, Lian Min, Zhang Weici, Eric Gershwin M., Ma Xiong, The Immunologic Paradoxes of IgG4-Related Disease, Clinical Reviews in Allergy & Immunology, 54, 2, 2018. Crossref
-
Manni Sabrina, Carrino Marilena, Semenzato Gianpietro, Piazza Francesco, Old and Young Actors Playing Novel Roles in the Drama of Multiple Myeloma Bone Marrow Microenvironment Dependent Drug Resistance, International Journal of Molecular Sciences, 19, 5, 2018. Crossref
-
Carew Nolan, Nelson Ashley, Liang Zhitao, Smith Sage, Milcarek Christine, Linking Endoplasmic Reticular Stress and Alternative Splicing, International Journal of Molecular Sciences, 19, 12, 2018. Crossref
-
Nelson Ashley M., Carew Nolan T., Smith Sage M., Milcarek Christine, RNA Splicing in the Transition from B Cells to Antibody-Secreting Cells: The Influences of ELL2, Small Nuclear RNA, and Endoplasmic Reticulum Stress, The Journal of Immunology, 201, 10, 2018. Crossref
-
Garrett-Sinha Lee Ann, B Cell Immunity, in Management of Infections in the Immunocompromised Host, 2018. Crossref
-
Papp Bela, Launay Sophie, Gélébart Pascal, Arbabian Atousa, Enyedi Agnes, Brouland Jean-Philippe, Carosella Edgardo D., Adle-Biassette Homa, Endoplasmic Reticulum Calcium Pumps and Tumor Cell Differentiation, International Journal of Molecular Sciences, 21, 9, 2020. Crossref
-
Deyà-Martínez A., Alonso-Saladrigues A., García A. P., Faura A., Torrebadell M., Vlagea A., Català A., Esteve-Solé A., Juan M., Rives S., Alsina L., Kinetics of humoral deficiency in CART19-treated children and young adults with acute lymphoblastic leukaemia, Bone Marrow Transplantation, 56, 2, 2021. Crossref
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Rogers Geoffrey L., Cannon Paula M., Genome edited B cells: a new frontier in immune cell therapies, Molecular Therapy, 29, 11, 2021. Crossref