Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Critical Reviews™ in Immunology
Factor de Impacto: 1.404 Factor de Impacto de 5 años: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimir: 1040-8401
ISSN En Línea: 2162-6472

Volumes:
Volumen 40, 2020 Volumen 39, 2019 Volumen 38, 2018 Volumen 37, 2017 Volumen 36, 2016 Volumen 35, 2015 Volumen 34, 2014 Volumen 33, 2013 Volumen 32, 2012 Volumen 31, 2011 Volumen 30, 2010 Volumen 29, 2009 Volumen 28, 2008 Volumen 27, 2007 Volumen 26, 2006 Volumen 25, 2005 Volumen 24, 2004 Volumen 23, 2003 Volumen 22, 2002 Volumen 21, 2001 Volumen 20, 2000 Volumen 19, 1999 Volumen 18, 1998 Volumen 17, 1997 Volumen 16, 1996 Volumen 15, 1995 Volumen 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v24.i3.40
24 pages

C and CX3C Chemokines: Cell Sources and Physiopathological Implications

Laura Stievano
Department of Oncology and Surgical Sciences, Oncology Section, University of Padova, I-35128, Italy
Erich Piovan
Department of Oncology and Surgical Sciences, Oncology Section, University of Padova, I-35128, Italy
Alberto Amadori
Department of Oncology and Surgical Sciences, Oncology Section, University of Padova, I-35128, Italy

SINOPSIS

Within the fascinating world of chemokines, C and CX3C chemokines have long been regarded as two minor components, even though they present unique features and show less redundancy than the other chemokine families. Nevertheless, the body of data on their expression and role in various inflammatory disorders has grown in the past few years. The C chemokine family is represented by two chemokines, XCL1/lymphotactin-α and XCL2/lymphotactin-β, whereas the CX3C chemokine family contains only one member, called CX3CL1/ fractalkine. In this review, we present an overview on the structure, expression and signaling properties of these chemokines and their respective receptors and examine how they contribute to inflammation and the regulation of leukocyte trafficking, as well as their potential role in the pathophysiology of human inflammatory diseases. Taken together, these data expand the biological importance of C and CX3C chemokines from that of simple immune modulators to a much broader biological role, even though their precise commitment within the framework of immune responses has still to be determined.


Articles with similar content:

Pyrin and Hematopoietic Interferon-Inducible Nuclear Protein Domain Proteins: Innate Immune Sensors for Cytosolic and Nuclear DNA
Critical Reviews™ in Immunology, Vol.39, 2019, issue 4
Dieter Kabelitz, Gholamreza Daryabor, Mohammad Reza Atashzar, Kurosh Kalantar
Role of Galectin-3 in the Initial Control of Leishmania Infection
Critical Reviews™ in Immunology, Vol.34, 2014, issue 2
Guillaume St-Pierre, Pampa Bhaumik, Isabelle Pelletier, Sachiko Sato
Role of Activin A in the Induction of Foxp3+ and Foxp3− CD4+ Regulatory T Cells
Critical Reviews™ in Immunology, Vol.31, 2011, issue 1
Christoph Schramm, Samuel Huber
An Integrated Biological Approach to Nuclear Receptor Signaling in Physiological Control and Disease
Critical Reviews™ in Eukaryotic Gene Expression, Vol.16, 2006, issue 1
Carsten Carlberg, Thomas W. Dunlop
Developmental and Tissue-Specific Regulation of Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Gene Expression
Critical Reviews™ in Eukaryotic Gene Expression, Vol.10, 2000, issue 2
David Goltzman, John H. White