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Critical Reviews™ in Immunology

Publicado 6 números por año

ISSN Imprimir: 1040-8401

ISSN En Línea: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Positive and Negative Thymocyte Selection

Volumen 18, Edición 4, 1998, pp. 359-370
DOI: 10.1615/CritRevImmunol.v18.i4.40
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SINOPSIS

T cells differentiate from CD4-CD8- (DN) precursor to mature CD4+ or CD8+ (SP) thymocytes through the CD4+CD8+ (DP) stage. Immature thymocytes express pre-TCR complex composed of pTα and TCRβ chains, which plays a role in allelic exclusion of TCRβ and promotion from DN to DP transition. During the DP stage, thymocytes are subjected for selection, either expansion/differentiation into SP cells (positive selection) or deletion (negative selection). The level of TCR signals, which is mainly affected by the avidity between TCR and self-peptide/MHC and the contribution of coreceptors (CD4, CD8), determines the fate of thymocytes. The difference of avidity may result in distinct kinetics when signaling machinery assembles with TCR. As TCR signals increase either by high expression of TCR/coreceptors or higher avidity, the fate of thymocytes changes from default death (no selection) to positive selection and then negative selection. Although signaling pathways to discriminate these selections are largely unknown, ZAP-70 and Lck are important for both processes, whereas calcineurin and MARK pathway play crucial roles in positive selection. TCR signals also affect the CD4/CD8 lineage commitment. The requirements for the two lineages are different. Differentiation of CD4 SP thymocytes requires stronger TCR signals, while special signals such as Notch-mediated signal are necessary for development of CD8+ cells.

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