Publicado 4 números por año
ISSN Imprimir: 1050-6934
ISSN En Línea: 1940-4379
Indexed in
Static and Flow Conditions: Endothelial Cell Migration onto Metal Stent Surfaces
SINOPSIS
Restenosis associated with intimal hyperplasia and thrombosis at sites of balloon angioplasty or stent placement remains an important clinical problem. It is likely that loss or damage to the arterial endothelium associated with these interventional procedures as well as the rate of its restoration plays a critical role in the extent of restenosis. Migration of arterial endothelial cells from adjacent intact endothelium is the predominant source of cells involved in re-endothelialization of the injured site. In this paper, we review the influence of hemodynamics on endothelial cell migration, both in vivo and in vitro. In addition, we present recent in vitro studies demonstrating the importance of the nature of metal substrates in modulating endothelial cell migration rate. Finally, we review the cellular and molecular mechanisms likely involved in governing endothelial cell migration, and relate them to a possible scenario of endothelial response to injury at sites of arterial intervention. Understanding the important factors regulating endothelial migration may provide insights that will ultimately lead to methods to accelerate endothelial healing and reduce the occurrence of arterial restenosis.
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Xu Ning, Meng Hao, Liu Tianyi, Feng Yingli, Qi Yuan, Zhang Donghuan, Wang Honglei, Stent-Jailing Technique Reduces Aneurysm Recurrence More Than Stent-Jack Technique by Causing Less Mechanical Forces and Angiogenesis and Inhibiting TGF-β/Smad2,3,4 Signaling Pathway in Intracranial Aneurysm Patients, Frontiers in Physiology, 9, 2019. Crossref
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Timizheva K. B., Azova M. M., Aissa A. Ait, Aghajanyan A. V., Tskhovrebova L. V., Blagonravov M. L., Association of Gene Polymorphisms of Some Endothelial Factors with Stent Reendothelization after Elective Coronary Artery Revascularization, Bulletin of Experimental Biology and Medicine, 171, 2, 2021. Crossref