Publicado 4 números por año
ISSN Imprimir: 1050-6934
ISSN En Línea: 1940-4379
Indexed in
The Neglected Villain of Bioprosthetic Degeneration: Inflammatory and Immune Processes
SINOPSIS
In an attempt to avoid the destructive process of bioprosthetic heart-valve calcification associated with the use of glutaraldehyde, valves are today prepared using low concentrations of the crosslinking reagent. In this review, we summarize our findings and those of others that confirm that the immunogenicity of such tissue is not sufficiently masked and that a defined humoral response is indeed mounted against a repertoire of antigens unrelated to those associated with vascularized and noncross-linked xenograft organs. We demonstrate the need for increased cross-linking of tissue to satisfactorily mitigate that response; furthermore, we examine the impact of increased cross-link density on the macrophage as antigen presenting cell with respect to its involvement in both tissue erosion and pannus overgrowth. Finally we present evidence for a role of circulating antibodies in bioprosthesis calcification.
-
Human Paul, Ofoegbu Chima, Ilsley Helen, Bezuidenhout Deon, de Villiers Jandre, Williams David F, Zilla Peter, Decellularization and engineered crosslinking: a promising dual approach towards bioprosthetic heart valve longevity, European Journal of Cardio-Thoracic Surgery, 58, 6, 2020. Crossref
-
Fioretta Emanuela S., Motta Sarah E., Gähwiler Eric K. N., Poulis Nikolaos, Emmert Maximilian Y., Hoerstrup Simon P., Heart Valve Bioengineering, in Organ Tissue Engineering, 2020. Crossref
-
Williams David F., Bezuidenhout Deon, de Villiers Jandre, Human Paul, Zilla Peter, Long-Term Stability and Biocompatibility of Pericardial Bioprosthetic Heart Valves, Frontiers in Cardiovascular Medicine, 8, 2021. Crossref
-
Fioretta Emanuela S., Motta Sarah E., Gähwiler Eric K. N., Poulis Nikolaos, Emmert Maximilian Y., Hoerstrup Simon P., Heart Valve Bioengineering, in Organ Tissue Engineering, 2021. Crossref
-
Fioretta Emanuela S., Motta Sarah E., Lintas Valentina, Loerakker Sandra, Parker Kevin K., Baaijens Frank P. T., Falk Volkmar, Hoerstrup Simon P., Emmert Maximilian Y., Next-generation tissue-engineered heart valves with repair, remodelling and regeneration capacity, Nature Reviews Cardiology, 18, 2, 2021. Crossref
-
Calafiore Antonio M, Haverich Axel, Gaudino Mario, Di Mauro Michele, Fattouch Khalil, Prapas Sotirios, Zilla Peter, Immunoreaction to xenogenic tissue in cardiac surgery: alpha-Gal and beyond, European Journal of Cardio-Thoracic Surgery, 62, 1, 2022. Crossref
-
Rioux Yannick, Fradette Julie, Maciel Yvan, Bégin-Drolet André, Ruel Jean, Biofabrication of Sodium Alginate Hydrogel Scaffolds for Heart Valve Tissue Engineering, International Journal of Molecular Sciences, 23, 15, 2022. Crossref