Publicado 4 números por año
ISSN Imprimir: 0731-8898
ISSN En Línea: 2162-6537
Indexed in
In Vitro Mitigation of Arsenic Toxicity by Tea Polyphenols in Human Lymphocytes
SINOPSIS
The groundwater arsenicals have brought dreadful misery for the people residing in the endemic regions of West Bengal, India. Arsenic-related anomalies include arsenicosis, hyperkera-tosis, gastric complications, liver fibrosis, peripheral neuropathy, and cancer. Some of these diseases have been frequently associated with overproduction of reactive oxygen species that cause DNA damage and improper functioning of body's antioxidant defense mechanism. Natural polyphenols present in tea serve as excellent antioxidants. In the present study, an attempt has been made to elucidate the role of representative polyphenols and extracts of green and black tea in modulating sodium arsenite (As III)−induced DNA damage in normal human lymphocytes. Comet assay was used to detect the DNA damage. Arsenic-induced oxidative stress was measured with generation of reactive oxygen species, lipid peroxidation, and activity of some antioxidant enzymes. Expression of some repair enzymes such as poly(ADP-ribose) polymerase and DNA polymerase β was measured to assess the effect of tea on DNA repair. Tea afforded efficient reduction of As III−induced DNA damage in human lymphocytes. Tea also quenched the excessive production of reactive oxygen species by arsenic, reduced the elevated levels of lipid peroxidation, and increased the activity of antioxidant enzymes such as catalase, superoxide dismutase, and glutathione peroxidase. Furthermore, tea enhanced recovery of DNA damage, which was indicative of repair as confirmed by unscheduled DNA synthesis and pronounced expression of DNA repair enzyme poly(ADP-ribose) polymerase. It is speculated that the antioxidant potential and repair-inducing capacity of tea might help in combating the severe genotoxic effects induced by arsenic in the human population.
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Sinha Dona, Biswas Jaydip, Bishayee Anupam, Nrf2-mediated redox signaling in arsenic carcinogenesis: a review, Archives of Toxicology, 87, 2, 2013. Crossref
-
Ferrer Miguel D., Sureda Antoni, Tauler Pedro, Palacín Clara, Tur Josep A., Pons Antoni, Impaired lymphocyte mitochondrial antioxidant defences in variegate porphyria are accompanied by more inducible reactive oxygen species production and DNA damage, British Journal of Haematology, 149, 5, 2010. Crossref
-
Soria Elio A., Quiroga Patricia L., Albrecht Claudia, Ramos Elizagaray Sabina I., Cantero Juan J., Bongiovanni Guillermina A., Development of an Antioxidant Phytoextract ofLantana grisebachiiwith Lymphoprotective Activity againstIn VitroArsenic Toxicity, Advances in Pharmacological Sciences, 2014, 2014. Crossref
-
Acharyya Nirmallya, Sajed Ali Sk., Deb Bimal, Chattopadhyay Sandip, Maiti Smarajit, Green tea (Camellia sinensis) alleviates arsenic-induced damages to DNA and intestinal tissues in rat andin situintestinal loop by reinforcing antioxidant system, Environmental Toxicology, 30, 9, 2015. Crossref
-
Iriel Analia, Dundas Gavin, Fernández Cirelli Alicia, Lagorio Maria G., Effect of arsenic on reflectance spectra and chlorophyll fluorescence of aquatic plants, Chemosphere, 119, 2015. Crossref
-
Sinha D., Roy S., Roy M., Antioxidant potential of tea reduces arsenite induced oxidative stress in Swiss albino mice, Food and Chemical Toxicology, 48, 4, 2010. Crossref
-
Banerjee Mayukh, Bhattacharjee Pritha, Giri Ashok K., Arsenic-induced Cancers: A Review with Special Reference to Gene, Environment and Their Interaction, Genes and Environment, 33, 4, 2011. Crossref
-
Iriel Analia, Lagorio M. Gabriela, Fernández Cirelli Alicia, Biosorption of arsenic from groundwater using Vallisneria gigantea plants. Kinetics, equilibrium and photophysical considerations, Chemosphere, 138, 2015. Crossref
-
Chen Lixia, Mo Huanbiao, Zhao Ling, Gao Weimin, Wang Shu, Cromie Meghan M., Lu Chuanwen, Wang Jia-Sheng, Shen Chwan-Li, Therapeutic properties of green tea against environmental insults, The Journal of Nutritional Biochemistry, 40, 2017. Crossref
-
Biswas Jaydip, Sinha Dona, Mukherjee Sutapa, Roy Soumi, Siddiqi Maqsood, Roy Madhumita, Curcumin protects DNA damage in a chronically arsenic-exposed population of West Bengal, Human & Experimental Toxicology, 29, 6, 2010. Crossref
-
Iriel Analia, Marco-Brown Jose L., Diljkan Maja, Trinelli María Alcira, dos Santos Afonso María, Fernández Cirelli Alicia, Arsenic Adsorption on Iron-Modified Montmorillonite: Kinetic Equilibrium and Surface Complexes, Environmental Engineering Science, 37, 1, 2020. Crossref
-
Ma Huijuan, Song Xiaodong, Huang Ping, Zhang Weiwei, Ling Xinyue, Yang Xiaoning, Wu Wenwei, Xu Huan, Wang Wei, Myricetin protects natural killer cells from arsenite induced DNA damage by attenuating oxidative stress and retaining poly(ADP-Ribose) polymerase 1 activity, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 865, 2021. Crossref
-
da Silva Cristiano José, Bastos Jairo Kenupp, Takahashi Catarina Satie, Evaluation of the genotoxic and cytotoxic effects of crude extracts of Cordia ecalyculata and Echinodorus grandiflorus, Journal of Ethnopharmacology, 127, 2, 2010. Crossref