Publicado 4 números por año
ISSN Imprimir: 0731-8898
ISSN En Línea: 2162-6537
Indexed in
Status of Selenium, Vitamin E, and Vitamin A among Saudi Adults: Potential Links with Common Endemic Diseases
SINOPSIS
This study was designed to determine the status of selenium, dl-α-tocopherol, and all-trans-retinol in adults living in Al-Kharj district using serum and toenail samples, and to look for possible association between these parameters and the etiology of endemic diseases in the same area. For this purpose, we examined a cross section of samples of 743 healthy Saudi adults on routine visits to the Primary Health Care Unites (PHCUs) for different common health problems. The arithmetic mean for selenium, dl-α-tocopherol, and all-trans-retinol in serum and toenail selenium levels were 107.045 ± 23.045 μg/l (n = 743, range 52.600−210.120 μg/l), 1.053 ± 0.324 mg/dl (n = 737, range 0.29−3.42 mg/dl), 52.561 ± 25.671 μg/dl (n = 743, range 11.20−400.85 μg/dl), and 0.634 ± 0.221 μg/g (n = 691, range < DL − 1.797 μg/g), respectively. The average serum selenium concentration seems to be satisfactory and compares favourably with high selenium intake countries. Although none of our participants exhibited serum selenium deficiency (< 45 μg/l), 41% of our participants had toenail selenium < 0.56 μg/g reported low levels in the previous study. The mean serum dl-α-tocopherol concentrations fall within the upper limit of the normal range of > 0.698−1.981 mg/dl for α-tocopherol as found in previous studies. On the other hand, the mean serum all-trans-retinol is higher than the normal range (20−30 μg/dl). None had exhausted retinol stores <10 µg/dl. Significant negative association between all-trans-retinol and MDA levels in the serum was found as a sign of peroxidative lipid damage, confirming the role of vitamin A in reducing oxidative stress. Our data also revealed a link between the status of selenium, dl-α-tocopherol and all-trans-retinol and a number of health problems. However, these observations need larger epidemiological studies for further confirmation.
-
Al-Matary Abdulrahman, Hussain Mushtaq, Ali Jaffar, Selenium: a brief review and a case report of selenium responsive cardiomyopathy, BMC Pediatrics, 13, 1, 2013. Crossref
-
Vieira Rocha Ariana, Rita Cardoso Bárbara, Cominetti Cristiane, Barofaldi Bueno Rafael, de Bortoli Maritsa Carla, Farias Luciana Aparecida, Teixeira Favaro Déborah Inês, Aranha Camargo Luís Marcelo, Franciscato Cozzolino Silvia Maria, Selenium status and hair mercury levels in riverine children from Rondônia, Amazonia, Nutrition, 30, 11-12, 2014. Crossref
-
Cardoso Bárbara Rita, Ong Thomas Prates, Jacob-Filho Wilson, Jaluul Omar, Freitas Maria Isabel d'Ávila, Cozzolino Silvia M. Franciscato, Nutritional status of selenium in Alzheimer's disease patients, British Journal of Nutrition, 103, 6, 2010. Crossref
-
Stoffaneller Rita, Morse Nancy, A Review of Dietary Selenium Intake and Selenium Status in Europe and the Middle East, Nutrients, 7, 3, 2015. Crossref
-
Fett Carlos Alexandre, Fett Waléria Christiane Rezende, Padovan Gilberto João, Marchini Julio Sergio, Mudanças no estilo de vida e fatores de risco para doenças crônicas não transmissíveis e sistema imune de mulheres sedentárias, Revista de Nutrição, 22, 2, 2009. Crossref
-
Malik Anku, Eggersdorfer Manfred, Trilok-Kumar Geeta, Vitamin E status in healthy population in Asia: A review of current literature, International Journal for Vitamin and Nutrition Research, 91, 3-4, 2021. Crossref
-
Ibrahim Sohayla A. Z., Kerkadi Abdelhamid, Agouni Abdelali, Selenium and Health: An Update on the Situation in the Middle East and North Africa, Nutrients, 11, 7, 2019. Crossref