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Journal of Environmental Pathology, Toxicology and Oncology
Factor de Impacto: 1.625 Factor de Impacto de 5 años: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN Imprimir: 0731-8898
ISSN En Línea: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v25.i1-2.250
pages 403-410

Pretreatment of Plantar Warts with Azone Enhances the Effect of 5-Aminolevulinic Acid Photodynamic Therapy

Piotr Ziolkowski
Department of Pathology, Wroclaw Medical University, Poland
Beata J. Osiecka
Department of Pathology, Wroclaw Medical University, Poland
Maciej Siewinski
Department of Public Health, Wroclaw Medical University, Poland
Andrzej Bronowicz
Department of Pathology, Wroclaw Medical University, Poland
Jolanta Ziolkowska
Department of Internal Medicine, Occupational Diseases and Hypertension, Wroclaw Medical University, 1 Marcinkowskiego Street, 50-368 Wroclaw, Poland
Hanna Gerber-Leszczyszyn
Department of Maxillofacial Surgery, Wroclaw Medical University, 1 Marcinkowskiego Street, 50-368 Wroclaw, Poland

SINOPSIS

5-Aminolevulinic acid (5-ALA) is a well characterized precursor in the synthesis of various endogenous porphyrins used in photodynamic therapy (PDT). It is most often administered topically into a tumor which is then irradiated with visible light at established wavelength to sensitize porphyrins accumulated therein. Our main aim in the present study was to increase the penetration of 5-ALA through the altered skin by application of 3% azone (1-dodecyl-azepan-2-one) before the application of 20% 5-ALA in patients with plantar warts: mosaic warts (MW) and myrmecia (MY). We also used 20% 5-ALA only to treat warts in other patients. We compared the therapeutic and cosmetic effects of the two treatment modalities. The lesions treated with modification of 5-ALA-PDT by pretreatment with azone responded with better effectiveness. In 18 patients subjected to 5-ALA-PDT plus 3% azone, we observed 66.7% complete response of MW and 100% of MY following PDT repeated two or three times; whereas in other 18 patients treated with 5-ALA-PDT alone, we observed only 37.5% complete response of MW and 70% of MY. These results provide evidence that the pretreatment with azone should be considered as the step that enhances 5-ALA penetration in tissues and thus increases the effectiveness of applied PDT.


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