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Journal of Environmental Pathology, Toxicology and Oncology

Publicado 4 números por año

ISSN Imprimir: 0731-8898

ISSN En Línea: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Characterization of Microcystin-Induced Dualistic Toxic Effects on Primary Rat Hepatocytes

Volumen 36, Edición 1, 2017, pp. 15-27
DOI: 10.1615/JEnvironPatholToxicolOncol.2016017340
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SINOPSIS

Microcystins (MCs) comprise a group of widely characterized cyclic heptapeptides able to induce a series of liver injuries, including acute liver failure and primary liver cancer. Although the dualistic effects of MCs have been postulated, the specific action mode according to the exposure dosage of MCs remains unknown. In the present study, primarily cultured rat hepatocytes were used to systematically investigate hepatotoxic characteristics of MC-LR (one of the most abundant and toxic MCs variants). Results showed that the dualistic toxicity of MC-LR on hepatocytes is dose dependent. Specifically, MC-LR at a high dose (>10-8 mol/L) induced a significant reduction in cell viability, whereas low-dose MC-LR (<10-8 mol/L) was observed to promote cell proliferation. Oxidative stress measurements showed that reactive oxygen species (ROS) levels undergo a massive and rapid increase in high-dose MC-LR–treated hepatocytes and a mild and slow increase in low-dose MC-LR–treated hepatocytes. These in vitro data suggest that MC-LR is able to exert dualistic toxic effects on hepatocytes through the "two-faced" character of ROS, which causes cell death or even necrosis at high concentrations and promotes cell proliferation exclusively at low or transient concentrations.

CITADO POR
  1. Baralla Elena, Varoni Maria Vittoria, Sedda Tiziana, Pasciu Valeria, Floris Antonello, Demontis Maria Piera, Microcystins Presence in Mussels(M. galloprovincialis)and Water of Two Productive Mediterranean’s Lagoons (Sardinia, Italy), BioMed Research International, 2017, 2017. Crossref

  2. Xu Yonghua, Wang Xiangmin, Jiang Surong, Men Chen, Xu Di, Guo Yan, Wu Jun, Microcystin-LR regulates circadian clock and antioxidant gene expression in cultured rat cardiomyocytes, Cellular & Molecular Biology Letters, 23, 1, 2018. Crossref

  3. Wu Yun-Li, He Yun, Shi Jia-Jian, Zheng Tian-Xiu, Lin Xin-Jian, Lin Xu, Microcystin-LR promotes necroptosis in primary mouse hepatocytes by overproducing reactive oxygen species, Toxicology and Applied Pharmacology, 377, 2019. Crossref

  4. Wang Rui, Liu Xiaohui, Wu Jinxia, Liu Haohao, Wang Wenjun, Chen Xinghai, Yuan Le, Wang Yueqin, Du Xingde, Ma Ya, Losiewicz Michael D., Zhang Xiaofeng, Zhang Huizhen, Role of microRNA‐122 in microcystin‐leucine arginine‐induced dysregulation of hepatic iron homeostasis in mice, Environmental Toxicology, 35, 8, 2020. Crossref

  5. Basu Amrita, Dydowiczová Aneta, Čtveráčková Lucie, Jaša Libor, Trosko James E., Bláha Luděk, Babica Pavel, Assessment of Hepatotoxic Potential of Cyanobacterial Toxins Using 3D In Vitro Model of Adult Human Liver Stem Cells, Environmental Science & Technology, 52, 17, 2018. Crossref

  6. Alosman Muwaffak, Cao Linghui, Massey Isaac Yaw, Yang Fei, The lethal effects and determinants of microcystin-LR on heart: a mini review, Toxin Reviews, 40, 4, 2021. Crossref

  7. Raska Jan, Ctverackova Lucie, Dydowiczova Aneta, Sovadinova Iva, Blaha Ludek, Babica Pavel, Tumor-promoting cyanotoxin microcystin-LR does not induce procarcinogenic events in adult human liver stem cells, Toxicology and Applied Pharmacology, 345, 2018. Crossref

  8. Shi Jun, Zhang Min, Zhang Libin, Deng Huipin, Epigallocatechin-3-gallate attenuates microcystin-LR-induced apoptosis in human umbilical vein endothelial cells through activation of the NRF2/HO-1 pathway, Environmental Pollution, 239, 2018. Crossref

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