Publicado 4 números por año
ISSN Imprimir: 0731-8898
ISSN En Línea: 2162-6537
IF:
2.4
5-Year IF:
2.8
Immediacy Index:
0.5
Eigenfactor:
0.00049
JCI:
0.59
SJR:
0.429
SNIP:
0.507
CiteScore™::
3.9
H-Index:
49
Indexed in
Evaluation of Evidenced-Based Radioprotective Effi cacy of Gymnema sylvestre Leaves in Mice Brain
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SINOPSIS
A Gymnema sylvestre leaves extract (GSE) rich in gymnemic acids was examined for its antioxidant activities through various in vitro assays, along with its radioprotective efficacy in mice brain. The IC50 values of GSE for 2,2-diphenyl-1-picrylhydrazyl scavenging assays, superoxide radical scavenging assays, inhibition of in vitro lipid peroxidation assays, and protein carbonyl formation assay were 238, 140, 99.46, and 28.03 μg/mL, respectively. Furthermore, the total phenolic content in GSE was equivalent to 18.06 μg/mL of Gallic acid. The rate of •OH radical scavenging activity of GSE is 0.46 times slower than SCN− derived from nanosecond pulse radiolysis studies. Results of in vivo studies showed that radiation (8 Gy)-induced augmentation in the levels of lipid peroxidation and depletion in glutathione and protein levels in mice brain were significantly ameliorated by GSE pretreatment. Results suggest that the radioprotective effi cacy of GSE may be due to its antioxidant properties.
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