Publicado 4 números por año
ISSN Imprimir: 0731-8898
ISSN En Línea: 2162-6537
IF:
2.4
5-Year IF:
2.8
Immediacy Index:
0.5
Eigenfactor:
0.00049
JCI:
0.59
SJR:
0.429
SNIP:
0.507
CiteScore™::
3.9
H-Index:
49
Indexed in
Antiarthritic Activity of Diallyl Disulfide against Freund’s Adjuvant–Induced Arthritic Rat Model
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SINOPSIS
Diallyl disulfide (DADS) is an organosulfur compound derived mainly from garlic and genus Allium plants, which possess diverse biological properties. The aim of the present study was to evaluate the antiarthritic activity of DADS in rats with arthritis induced using complete Freund's adjuvant (CFA). DADS (20 mg/kg and 50 mg/kg) was administered and tested against CFA-induced arthritic rats by assessing various parameters: body weight, paw volume, arthritic score, organ indices (spleen and thymus), hematological and biochemical parameters, and proinflammatory cytokines. Histopathological analyses were also performed. The treatment of rats with DADS provoked significant reductions in paw volume, edema formation, arthritic score, and organ indices, together with significant improvement in body weight. DADS treatment also improved joint destruction and reduced inflammation, which was supported by histopathological studies. DADS significantly reduced the white blood cell count and improved red blood cell count in CFA-induced rats. The anti-arthritic activity in the CFA-induced rats was further confirmed by biochemical analysis. These findings suggest that DADS prevented cartilage destruction, improved health status, and reduced inflammation by decreasing the expression of proinflammatory cytokines in arthritis-induced rats. Hence, DADS may be a potential therapeutic candidate for the treatment of rheumatoid arthritis.
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Dilek Nahzli, Papapetropoulos Andreas, Toliver-Kinsky Tracy, Szabo Csaba, Hydrogen sulfide: An endogenous regulator of the immune system, Pharmacological Research, 161, 2020. Crossref
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Li M., Mao Jian-Chun, Zhu Yi-Zhun, Hydrogen Sulfide: a Novel Immunoinflammatory Regulator in Rheumatoid Arthritis, in Advances in Hydrogen Sulfide Biology, 1315, 2021. Crossref
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