Publicado 4 números por año
ISSN Imprimir: 0731-8898
ISSN En Línea: 2162-6537
Indexed in
Sister Chromatid Exchanges and Micronuclei in Lymphocytes of Operating Room Personnel Occupationally Exposed to Enfluorane and Nitrous Oxide
SINOPSIS
The objective of this article is to assess whether occupational exposure to anesthetics increases genotoxic risk.We investigated two cytogenetic biomarkers, sister chromatid exchanges (SCE) and micronuclei (MN), in the peripheral blood lymphocytes of 46 anesthesiologists (24 men), working in operating rooms and mostly exposed to enfluorane and nitrous oxide, and 66 controls (35 men), not exposed to chemicals and living in the same area. Contrary to what was expected, a lower frequency of SCE was found in male anesthesiologists than in controls. Smoking status was found to be positively associated with SCE frequency in each group, while no relation to age was evident. On the contrary, MN frequency was significantly higher in female, but not male, anesthesiologists than in controls. Age and smoking status did not modify the association.No relationship between MN frequency and duration of employment was found in anesthesiologists. Smoking status and mean number of cigarettes smoked per day in smokers were not associated with MN frequency in either anesthesiologists or in controls. MN analysis seems to be a sensitive index of possible genotoxic effects of occupational exposure to anesthesiologists, and women appear to be more susceptible to these effects than men.
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Eroglu Ahmet, Celep Figen, Erciyes Nesrin, A Comparison of Sister Chromatid Exchanges in Lymphocytes of Anesthesiologists to Nonanesthesiologists in the Same Hospital, Anesthesia & Analgesia, 102, 5, 2006. Crossref
-
Araujo Tânia Kawasaki de, da Silva-Grecco Roseane Lopes, Bisinotto Flora Margarida Barra, Roso Nilson Camargos, Pissetti Cristina Wide, da Cruz Ricardo Manoel, Balarin Marly Aparecida Spadotto, Genotoxic effects of anesthetics in operating room personnel evaluated by micronucleus test, journal of Anesthesiology and Clinical Science, 2, 1, 2013. Crossref
-
Jang Yeon, Song Ho Kyung, Jeong Dae Chul, Lee Seung-Hwan, The effects of propofol and enflurane anesthesia on the proliferative responsiveness of peripheral blood mononuclear cells in culture as determined by the level of bromodeoxyuridine incorporation, Korean Journal of Anesthesiology, 55, 4, 2008. Crossref
-
Fodale V, Mondello S, Aloisi C, Schifilliti D, Santamaria LB, Genotoxic effects of anesthetic agents, Expert Opinion on Drug Safety, 7, 4, 2008. Crossref
-
Wrońska-Nofer Teresa, Palus Jadwiga, Krajewski Wojciech, Jajte Jolanta, Kucharska Małgorzata, Stetkiewicz Jan, Wąsowicz Wojciech, Rydzyński Konrad, DNA damage induced by nitrous oxide: Study in medical personnel of operating rooms, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 666, 1-2, 2009. Crossref
-
OTHER, British Journal of Anaesthesia, 108, 2012. Crossref
-
Wrońska-Nofer Teresa, Nofer Jerzy-Roch, Jajte Jolanta, Dziubałtowska Elżbieta, Szymczak Wiesław, Krajewski Wojciech, Wąsowicz Wojciech, Rydzyński Konrad, Oxidative DNA damage and oxidative stress in subjects occupationally exposed to nitrous oxide (N2O), Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 731, 1-2, 2012. Crossref
-
Szyfter Krzysztof, Stachecki Ireneusz, Kostrzewska-Poczekaj Magdalena, Szaumkessel Marcin, Szyfter-Harris Joanna, Sobczyński Paweł, Exposure to volatile anaesthetics is not followed by a massive induction of single-strand DNA breaks in operation theatre personnel, Journal of Applied Genetics, 57, 3, 2016. Crossref
-
Bonassi Stefano, Neri Monica, Lando Cecilia, Ceppi Marcello, Lin Yi-ping, Chang Wushou P, Holland Nina, Kirsch-Volders Micheline, Zeiger Errol, Fenech Michael, Effect of smoking habit on the frequency of micronuclei in human lymphocytes: results from the Human MicroNucleus project, Mutation Research/Reviews in Mutation Research, 543, 2, 2003. Crossref
-
Lewińska D., Stępnik M., Krajewski W., Arkusz J., Stańczyk M., Wrońska-Nofer T., Increased incidence of micronuclei assessed with the micronucleus assay and the fluorescence in situ hybridization (FISH) technique in peripheral blood lymphocytes of nurses exposed to nitrous oxide, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 581, 1-2, 2005. Crossref
-
Vodicka Pavel, Musak Ludovit, Fiorito Giovanni, Vymetalkova Veronika, Vodickova Ludmila, Naccarati Alessio, DNA and chromosomal damage in medical workers exposed to anaesthetic gases assessed by the lymphocyte cytokinesis-block micronucleus (CBMN) assay. A critical review, Mutation Research/Reviews in Mutation Research, 770, 2016. Crossref
-
Schifilliti Daniela, Mondello Stefania, D'Arrigo Maria Gabriella, Chillè Giovanni, Fodale Vincenzo, Genotoxic effects of anesthetic agents: an update, Expert Opinion on Drug Safety, 10, 6, 2011. Crossref
-
Souza Kátina M., Braz Leandro G., Nogueira Flávia R., Souza Marajane B., Bincoleto Lahis F., Aun Aline G., Corrente José E., Carvalho Lídia R., Braz José Reinaldo C., Braz Mariana G., Occupational exposure to anesthetics leads to genomic instability, cytotoxicity and proliferative changes, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 791-792, 2016. Crossref
-
El-Ebiary AA, Abuelfadl AA, Sarhan NI, Othman MM, Assessment of genotoxicity risk in operation room personnel by the alkaline comet assay, Human & Experimental Toxicology, 32, 6, 2013. Crossref
-
Darkwa Ebenezer Owusu, Djagbletey Robert, Ofosu-Appiah Ernest, Owoo Christian, Sottie Daniel A. Y., Essuman Raymond, Aryee George, Knowledge of Anaesthesia Providers on Exposure to Inhalational Anaesthetic Agents in Ghana, Journal of Biosciences and Medicines, 05, 04, 2017. Crossref
-
Kargar Shouroki Fatemeh, Neghab Masoud, Mozdarani Hossein, Alipour Hamzeh, Yousefinejad Saeed, Fardid Reza, Genotoxicity of inhalational anesthetics and its relationship with the polymorphisms of GSTT1, GSTM1, and GSTP1 genes, Environmental Science and Pollution Research, 26, 4, 2019. Crossref
-
Bilban M, Jakopin C Bilban, Ogrinc D, Cytogenetic tests performed on operating room personnel (the use of anaesthetic gases), International Archives of Occupational and Environmental Health, 78, 1, 2005. Crossref
-
Nilsson Roland, Björdal Chatarina, Andersson Matts, Björdal Jörn, Nyberg Anna, Welin Bengt, Willman Ania, Health risks and occupational exposure to volatile anaesthetics - a review with a systematic approach, Journal of Clinical Nursing, 14, 2, 2005. Crossref
-
Neghab Masoud, Kargar-Shouroki Fatemeh, Mozdarani Hossein, Yousefinejad Saeed, Alipour Hamzeh, Fardid Reza, Association between genotoxic properties of inhalation anesthetics and oxidative stress biomarkers, Toxicology and Industrial Health, 36, 6, 2020. Crossref
-
Figueiredo Drielle B. S., Aun Aline G., Souza Kátina M., Nishimoto Igor H., Silva Mariane A. P., de Carvalho Lídia R., Braz Leandro G., Braz Mariana G., High anesthetic (isoflurane) indoor pollution is associated with genetic instability, cytotoxicity, and proliferative alterations in professionals working in a veterinary hospital, Environmental Science and Pollution Research, 2022. Crossref
-
van Amsterdam Jan, van den Brink Wim, Nitrous oxide–induced reproductive risks: Should recreational nitrous oxide users worry?, Journal of Psychopharmacology, 36, 8, 2022. Crossref
-
Silva Mariane A. P., Figueiredo Drielle B. S., Lara Juliana R., Paschoalinotte Eloisa E., Braz Leandro G., Braz Mariana G., Evaluation of genetic instability, oxidative stress, and metabolism-related gene polymorphisms in workers exposed to waste anesthetic gases, Environmental Science and Pollution Research, 2022. Crossref