Publicado 4 números por año
ISSN Imprimir: 0731-8898
ISSN En Línea: 2162-6537
Indexed in
Tissue Levels of Arsenicals and Skin Tumor Response Following Administration of Monomethylarsonous Acid and Arsenite to K6/ODC Mice
SINOPSIS
The effects of monomethylarsonous acid (MMA[III]) and arsenite, administered in drinking water on tissue levels of arsenicals, cytogenetics, and mouse skin tumorigenicity were determined. A low-methionine diet modified the pattern of arsenical tissue concentrations and decreased the tissue arsenical concentrations, particularly in kidney and urinary bladder, less so in liver, and had little effect in the lungs. In mice given 75 ppm arsenite and a low-methionine diet, the urinary bladder tissue levels were only 29%, 26%, and 38% of the inorganic arsenic (iAs), MMA, and dimethylarsinic acid (DMA) concentrations found in mice eating the control diet. In K6/ODC transgenic mice that consumed a normal diet (Purina 5002), a 26-week drinking water exposure to 10 ppm arsenite resulted in 5% of the treated animals having squamous skin tumors. Exposure to 10, 50, 75, or 150 ppm MMA(III) caused 5%, 6.7%, 5%, or 0% tumor-bearing animals. A low-methionine diet did not markedly change the incidence of skin tumors10 ppm arsenite led to 10% tumors. With a low-methionine diet, 10 and 50 ppm, MMA(III) caused 5% and 6.7% tumor-bearing animals. In comparing the frequency of tumors in the concurrent control groups (1/70, 1.4%) with the frequency of tumors in the pooled arsenical-treated responsive groups (8/122, 6.6%), there is an excess of 6 mouse skin tumors observed in the pooled arsenical-responsive treatment groups compared to the expected number of tumors based on frequency of tumors observed in concurrent control mice. In summary, studies with MMA(III) and arsenite-treated K6/ODC transgenic mice showed (1) a low-methionine diet substantially altered mouse tissue arsenical levels and (2) numerically elevated incidence of mouse skin tumors following arsenical exposures.
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Cohen Samuel M., Arnold Lora L., Beck Barbara D., Lewis Ari S., Eldan Michal, Evaluation of the carcinogenicity of inorganic arsenic, Critical Reviews in Toxicology, 43, 9, 2013. Crossref
-
Huang Tianfang, Barnett Joey V., Camenisch Todd D., Cardiac Epithelial-Mesenchymal Transition Is Blocked by Monomethylarsonous Acid (III), Toxicological Sciences, 142, 1, 2014. Crossref
-
Delker Don A., Geter David R., Roop Barbara C., Ward William O., Ahlborn Gene J., Allen James W., Nelson Gail M., Ouyang Ming, Welsh William, Chen Yan, O'Brien Thomas, Kitchin Kirk T., Oncogene expression profiles in K6/ODC mouse skin and papillomas following a chronic exposure to monomethylarsonous acid, Journal of Biochemical and Molecular Toxicology, 23, 6, 2009. Crossref
-
Tokar Erik J., Diwan Bhalchandra A., Thomas David J., Waalkes Michael P., Tumors and proliferative lesions in adult offspring after maternal exposure to methylarsonous acid during gestation in CD1 mice, Archives of Toxicology, 86, 6, 2012. Crossref
-
Methylarsenverbindungen [MAK Value Documentation in German language, 2014], in The MAK-Collection for Occupational Health and Safety, 2014. Crossref
-
Chilakapati Jaya, Wallace Kathleen, Hernandez-Zavala Araceli, Moore Tanya, Ren Hongzu, Kitchin Kirk T., Pharmacokinetic and Genomic Effects of Arsenite in Drinking Water on Mouse Lung in a 30-Day Exposure, Dose-Response, 13, 2, 2015. Crossref
-
Hartwig A., Methylarsenic compounds [MAK Value Documentation, 2014], in The MAK-Collection for Occupational Health and Safety, 2018. Crossref
-
Kitchin Kirk T., Conolly Rory, Arsenic-Induced Carcinogenesis—Oxidative Stress as a Possible Mode of Action and Future Research Needs for More Biologically Based Risk Assessment, Chemical Research in Toxicology, 23, 2, 2010. Crossref
-
Kitchin Kirk T., Arsenic's Interactions with Macromolecules and its Relationship to Carcinogenesis, in Biological Chemistry of Arsenic, Antimony and Bismuth, 2010. Crossref
-
Gobert Alain P., Latour Yvonne L., Asim Mohammad, Barry Daniel P., Allaman Margaret M., Finley Jordan L., Smith Thaddeus M., McNamara Kara M., Singh Kshipra, Sierra Johanna C., Delgado Alberto G., Luis Paula B., Schneider Claus, Washington M. Kay, Piazuelo M. Blanca, Zhao Shilin, Coburn Lori A., Wilson Keith T., Protective Role of Spermidine in Colitis and Colon Carcinogenesis, Gastroenterology, 162, 3, 2022. Crossref
-
Liao Pei-Ju, Hsu Kuang-Hung, Chiou Hung-Yi, Chen Chien-Jen, Lee Chih-Hung, Joint effects of genomic markers and urinary methylation capacity associated with inorganic arsenic metabolism on the occurrence of cancers among residents in arseniasis-endemic areas: A cohort subset with average fifteen-year follow-up, Biomedical Journal, 44, 6, 2021. Crossref