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Journal of Environmental Pathology, Toxicology and Oncology

Publicado 4 números por año

ISSN Imprimir: 0731-8898

ISSN En Línea: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Comparative evaluation of the cytotoxic and apoptotic potential of Poecilocerus pictus and Calotropis gigantea

Volumen 30, Edición 1, 2011, pp. 83-92
DOI: 10.1615/JEnvironPatholToxicolOncol.v30.i1.80
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SINOPSIS

Calotropis gigantea, the giant milkweed, is used traditionally for treatment against cancer and in Ayurveda as an antihelminthic, anti-pyretic and an anti-malarial agent. Poecilocerus pictus, an orthopteran insect feeds on Calotropis gigantea and both are known to possess cardiac glycosides. The increasing reports on the specific cytotoxicity of cardiac glycosides on human tumor cell lines led us to attempt characterization and comparative evaluation of cardenolides in both the insect and plant extracts for their anti-tumor and apoptotic potential. Chemical characterization using HPTLC, UV and IR analyses confirmed the presence of cardiac glycosides but differences in the components of the insect extract were indicative of biotransformation. The cytotoxicity studies revealed a more potent trend for the insect extract as compared to the plant extract on A549 and COLO205 cells. There was a considerably lesser measure of toxicity on WI38 cells and peripheral blood lymphocytes, while B16F1 remained unaffected by both the extracts. DNA ploidy analysis on COLO205 indicated that both the extracts induced dose dependent apoptosis. Thus both the insect and plant extracts differentiate between human cancer cells and normal cells and exhibit species specificity. Further investigations are necessary to establish both the extracts as promising lead candidates for antineoplastic activity.

CITADO POR
  1. Jacobo-Salcedo Maria del Rosario, Juárez-Vázquez Maria del Carmen, González-Espíndola Luis Ángel, Maciel-Torres Sandra Patricia, García-Carrancá Alejandro, Alonso-Castro Angel Josabad, Biological effects of aqueous extract from Turkey vulture Cathartes aura (Cathartidae) meat, Journal of Ethnopharmacology, 145, 2, 2013. Crossref

  2. Silva James Almada da, Becceneri Amanda Blanque, Mutti Hêmily Sanches, Martin Ana Carolina Baptista Moreno, Silva Maria Fátima das Graças Fernandes, Fernandes João Batista, Vieira Paulo Cezar, Cominetti Márcia Regina, Purification and differential biological effects of ginger-derived substances on normal and tumor cell lines, Journal of Chromatography B, 903, 2012. Crossref

  3. Van Itterbeeck Joost, Rakotomalala Andrianavalona Irina N., Rajemison Faneva I., Rakotondrasoa Johanna F., Ralantoarinaivo Valisoa R., Hugel Sylvain, Fisher Brian L., Diversity and Use of Edible Grasshoppers, Locusts, Crickets, and Katydids (Orthoptera) in Madagascar, Foods, 8, 12, 2019. Crossref

  4. Al Sulaibi Mazen A. M., Thiemann Carolin, Thiemann Thies, Chemical Constituents and Uses of Calotropis Procera and Calotropis Gigantea – A Review (Part I – The Plants as Material and Energy Resources), Open Chemistry Journal, 7, 1, 2020. Crossref

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