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Journal of Environmental Pathology, Toxicology and Oncology
Factor de Impacto: 1.625 Factor de Impacto de 5 años: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN Imprimir: 0731-8898
ISSN En Línea: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2016014030
pages 317-331

Effect of Chokeberry Juice on N-Nitrosodiethylamine-Induced Rat Liver Carcinogenesis

Malgorzata Kujawska
Department of Toxicology, Poznan University of Medical Sciences, 30 Dojazd Str., 60-631 Poznan, Poland
Patrycja Kant
Department of Toxicology, Poznan University of Medical Sciences, 30 Dojazd Str., 60-631 Poznan, Poland
Irene Hidalgo Mayoral
Department of Toxicology, Poznan University of Medical Sciences, 30 Dojazd Str., 60-631 Poznan, Poland
Ewa Ignatowicz
Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, 4 Swiecicki Str., 60-781, Poznań, Poland
Jan Sikora
Department of Clinical Immunology, Poznan University of Medical Sciences, 5d Rokietnicka Str., 60-806 Poznan, Poland
Jan Oszmianski
Department of Fruit, Vegetable, and Cereal Technology, Environmental and Life Science University, 37/41 Chelmonski Str., 51-630 Wroclaw, Poland
Janusz Czapski
Institute of Plant Origin Food Technology, Poznan University of Life Sciences, 31 Wojska Polskiego Str., 60-642 Poznan, Poland
Jadwiga Jodynis-Liebert
Department of Toxicology, Poznan University of Medical Sciences, 30 Dojazd Str., 60-631 Poznan, Poland

SINOPSIS

Because humans commonly consume chokeberry, especially as a nutritional supplement, it must be checked to determine whether its excessive ingestion can cause adverse effects, in particular, in the case of simultaneous exposure to some xenobiotics. From this point of view, we examined the impact of long-term cotreatment of rats with chokeberry juice and hepatic carcinogen N-nitrosodiethylamine (NDEA) on oxidative damages and neoplastic lesions in the liver of rats. Daily exposure to chokeberry juice in a concentration of 10 g/kg feed via diet for 13 wk led to an intensified hepatotoxic effect of NDEA (0.01% in drinking water for 13 wk), as evidenced by changes in histopathological architecture of liver tissue, increased lipid peroxidation, protein carbonyl formation, and DNA degradation. Moreover, we noticed an increase in relative liver weight and a decrease in body weight in this group in comparison to NDEA-alone treated animals. Chokeberry juice applied alone did not cause any adverse effects in rats. On the basis of these findings, it can be concluded that high doses and longterm administration of chokeberry juice may enhance tumor-promoting action of some chemical carcinogens.


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