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Journal of Environmental Pathology, Toxicology and Oncology

Publicado 4 números por año

ISSN Imprimir: 0731-8898

ISSN En Línea: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Cytotoxic and Genotoxic Effects of Electronic Cigarette Liquids on Human Mucosal Tissue Cultures of the Oropharynx

Volumen 35, Edición 4, 2016, pp. 343-354
DOI: 10.1615/JEnvironPatholToxicolOncol.2016016652
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SINOPSIS

The popularity of electronic cigarettes (ECs) is rapidly growing and ECs are claimed to be an uncritically regarded alternative to conventional cigarettes. The mucosal tissue of the upper aerodigestive tract (UADT) is the first contact organ for xenobiotics such as liquids of ECs. The aim of this study is to investigate the bimolecular effects of e-liquids on human pharyngeal tissue cultures to evaluate whether e-liquids and their components present a risk factor for head and neck squamous cell carcinoma. Fresh tissue samples of healthy oropharyngeal mucosa were assembled into mucosal tissue cultures. Two fruit-flavored liquids (FLs), one tobacco-flavored liquid (TL) (all containing nicotine), and the corresponding base mixtures (free of nicotine and flavor) were used in three different dilutions. Cytotoxicity was assessed using the water-soluble tetrazolium−8 assay. DNA fragmentation was quantified using alkaline microgel electrophoresis. All liquids caused a significant reduction in cell viability. FLs especially showed a higher toxicity than TL. DNA fragmentation significantly increased by incubation with FL, whereas treatment with TL did not show serious DNA damage. E-liquids are cytotoxic to oropharyngeal tissue, and some liquids can induce relevant DNA damage. Thus, mutagenicity for mucosa of the UADT and e-liquids as risk factors for head and neck cancer cannot entirely be ruled out. Only the implementation of standards and regulations for liquid production and distribution can ensure a valid scientific investigation and assessment of carcinogenic potential of long-term EC use.

CITADO POR
  1. Shaito A., Saliba J., Husari A., El-Harakeh M., Chhouri H., Hashem Y., Shihadeh A., El-Sabban M., Electronic Cigarette Smoke Impairs Normal Mesenchymal Stem Cell Differentiation, Scientific Reports, 7, 1, 2017. Crossref

  2. Kaur Gurjot, Muthumalage Thivanka, Rahman Irfan, Mechanisms of toxicity and biomarkers of flavoring and flavor enhancing chemicals in emerging tobacco and non-tobacco products, Toxicology Letters, 288, 2018. Crossref

  3. Ratajczak Alexsandra, Feleszko Wojciech, Smith Danielle M., Goniewicz Maciej, How close are we to definitively identifying the respiratory health effects of e-cigarettes?, Expert Review of Respiratory Medicine, 12, 7, 2018. Crossref

  4. Protano Carmela, Avino Pasquale, Manigrasso Maurizio, Vivaldi Valerio, Perna Franco, Valeriani Federica, Vitali Matteo, Environmental Electronic Vape Exposure from Four Different Generations of Electronic Cigarettes: Airborne Particulate Matter Levels, International Journal of Environmental Research and Public Health, 15, 10, 2018. Crossref

  5. Ween Miranda P., Whittall Jonathan J., Hamon Rhys, Reynolds Paul N., Hodge Sandra J., Phagocytosis and Inflammation: Exploring the effects of the components of E-cigarette vapor on macrophages, Physiological Reports, 5, 16, 2017. Crossref

  6. Sood Amika K., Kesic Matthew J., Hernandez Michelle L., Electronic cigarettes: One size does not fit all, Journal of Allergy and Clinical Immunology, 141, 6, 2018. Crossref

  7. Otero Claire E., Noeker Jacob A., Brown Mary M., Wavreil Florence D.M., Harvey Wendy A., Mitchell Kristen A., Heggland Sara J., Electronic cigarette liquid exposure induces flavor-dependent osteotoxicity and increases expression of a key bone marker, collagen type I, Journal of Applied Toxicology, 39, 6, 2019. Crossref

  8. Flach Susanne, Maniam Pavithran, Manickavasagam Jaiganesh, E‐cigarettes and head and neck cancers: A systematic review of the current literature, Clinical Otolaryngology, 44, 5, 2019. Crossref

  9. Ween Miranda P., Hamon Rhys, Macowan Matthew G., Thredgold Leigh, Reynolds Paul N., Hodge Sandra J., Effects of E‐cigarette E‐liquid components on bronchial epithelial cells: Demonstration of dysfunctional efferocytosis, Respirology, 25, 6, 2020. Crossref

  10. Soneji Samir S., Knutzen Kristin E., Villanti Andrea C., Use of Flavored E-Cigarettes Among Adolescents, Young Adults, and Older Adults: Findings From the Population Assessment for Tobacco and Health Study, Public Health Reports, 134, 3, 2019. Crossref

  11. Aghar Hanan, El-Khoury Nathalie, Reda Mahasen, Hamadeh Wissam, Krayem Hussein, Mansour Mohammad, Raouf Hawraa, Jaffa Miran A., Knowledge and attitudes towards E-cigarette use in Lebanon and their associated factors, BMC Public Health, 20, 1, 2020. Crossref

  12. Ebersole Jeffrey, Samburova Vera, Son Yeongkwon, Cappelli David, Demopoulos Christina, Capurro Antonina, Pinto Andres, Chrzan Brian, Kingsley Karl, Howard Katherine, Clark Nathaniel, Khlystov Andrey, Harmful chemicals emitted from electronic cigarettes and potential deleterious effects in the oral cavity, Tobacco Induced Diseases, 18, May, 2020. Crossref

  13. Smith Lauren C., Kallupi Marsida, Tieu Lani, Shankar Kokila, Jaquish Abigail, Barr Jamie, Su Yujuan, Velarde Nathan, Sedighim Sharona, Carrette Lieselot L. G., Klodnicki Mike, Sun Xin, de Guglielmo Giordano, George Olivier, Validation of a nicotine vapor self-administration model in rats with relevance to electronic cigarette use, Neuropsychopharmacology, 45, 11, 2020. Crossref

  14. Jackson Monica, Singh Kameshwar P., Lamb Thomas, McIntosh Scott, Rahman Irfan, Flavor Preference and Systemic Immunoglobulin Responses in E-Cigarette Users and Waterpipe and Tobacco Smokers: A Pilot Study, International Journal of Environmental Research and Public Health, 17, 2, 2020. Crossref

  15. Al-Saleh Iman, Elkhatib Rola, Al-Rajoudi Tahreer, Al-Qudaihi Ghofran, Manogarannogaran Pulicat, Eltabache Chafica, Alotaibi Aminah, Mummer Abdulrahman Bin, Almugbel Saad, Cytotoxic and genotoxic effects of e-liquids and their potential associations with nicotine, menthol and phthalate esters, Chemosphere, 249, 2020. Crossref

  16. Yang Irene, Sandeep Shelly, Rodriguez Jeannie, The oral health impact of electronic cigarette use: a systematic review, Critical Reviews in Toxicology, 50, 2, 2020. Crossref

  17. Szukalska Marta, Szyfter Krzysztof, Florek Ewa, Rodrigo Juan P., Rinaldo Alessandra, Mäkitie Antti A., Strojan Primož, Takes Robert P., Suárez Carlos, Saba Nabil F., Braakhuis Boudewijn J.M., Ferlito Alfio, Electronic Cigarettes and Head and Neck Cancer Risk—Current State of Art, Cancers, 12, 11, 2020. Crossref

  18. Watters Carolina, Brar Sabrina, Richards Claire, Niziol Rafal, Oropharyngeal cancer, InnovAiT: Education and inspiration for general practice, 13, 11, 2020. Crossref

  19. Wiest F., Scherzad A., Ickrath P., Poier N., Hackenberg S., Kleinsasser N., Untersuchungen zum Schädigungspotenzial durch den Konsum von E-Zigaretten, HNO, 69, 12, 2021. Crossref

  20. Amaro Emilie J., Shepard Nicholas, Moss Lewis, Karamitopoulos Mara, Lajam Claudette, Vaping and Orthopaedic Surgery, JBJS Reviews, 7, 1, 2019. Crossref

  21. El Chebib Hassan, McArthur Kiah, Gorbonosov Michelle, Domachowske Joseph B., Anaerobic Necrotizing Pneumonia: Another Potential Life-threatening Complication of Vaping?, Pediatrics, 145, 4, 2020. Crossref

  22. Stefaniak Aleksandr B., LeBouf Ryan F., Ranpara Anand C., Leonard Stephen S., Toxicology of flavoring- and cannabis-containing e-liquids used in electronic delivery systems, Pharmacology & Therapeutics, 224, 2021. Crossref

  23. Holliday R., Chaffee B.W., Jakubovics N.S., Kist R., Preshaw P.M., Electronic Cigarettes and Oral Health, Journal of Dental Research, 100, 9, 2021. Crossref

  24. Wilson Catherine, Tellez Freitas Claudia M., Awan Kamran Habib, Ajdaharian Janet, Geiler Jordan, Thirucenthilvelan Pratheeba, Adverse effects of E‐cigarettes on head, neck, and oral cells: A systematic review, Journal of Oral Pathology & Medicine, 51, 2, 2022. Crossref

  25. Al Rajeh Ahmed M., Mahmud Ilias, Al Imam Mahmudul Hassan, Rahman Muhammad Aziz, Al Shehri Fariss, Alomayrin Salman, Alfazae Nawaf, Elmosaad Yousif Mohammed, Alasqah Ibrahim, E-Cigarette Use among Male Smokers in Al-Ahsa, Kingdom of Saudi Arabia: A Cross-Sectional Study, International Journal of Environmental Research and Public Health, 20, 1, 2022. Crossref

  26. Forest Valérie, Mercier Clément, Pourchez Jérémie, Considerations on dosimetry for in vitro assessment of e-cigarette toxicity, Respiratory Research, 23, 1, 2022. Crossref

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