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Journal of Environmental Pathology, Toxicology and Oncology

Publicado 4 números por año

ISSN Imprimir: 0731-8898

ISSN En Línea: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Hepatoprotective Efficacy of Sharbat-e-Deenar Against Carbon Tetrachloride−Induced Liver Damage

Volumen 31, Edición 2, 2012, pp. 131-141
DOI: 10.1615/JEnvironPatholToxicolOncol.v31.i2.50
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SINOPSIS

This study was undertaken to evaluate the antioxidant and hepatoprotective efficacy of Sharbat-e-Deenar (SD) against carbon tetrachloride (CCl4)−induced hepatic damage in a rat model. The antioxidant activity of SD was estimated by DPPH assay, H2O2 assay, and total phenolic contents. SD therapy at doses of 1, 2, and 4 mL/kg, orally, was administered after CCl4 intoxication (1.5 mL/kg, intraperitoneally for 48 hours) in experimental animals. Hexobarbitone sleep time and bromosulfophthalein retention time also were determined against CCl4-induced liver damage. Exposure to CCl4 in experimental animals showed biochemical and histopathological deterioration in the liver. Treatment with SD showed a marked protection on biochemical parameters, that is, alanine transaminase, aspartate transaminase, albumin, and urea. SD therapy exhibited a protective effect by restoring the level of lipid peroxidation−reduced glutathione, adenosine triphosphate, and glucose-6-phosphatase (G-6-Pase). Treatment with SD significantly recovered the level of hexobarbitone sleep time and bromosulfophthalein retention time. DPPH and H2O2 assays showed antioxidant properties in a dose-dependent manner. Histopathological observations of liver sections showed recovery in liver architecture after SD treatment. These results indicate that SD exerts a protective effect on CCl4-induced hepatotoxicity, which may be due to its antioxidant properties.

CITADO POR
  1. Tan Hor-Yue, San-Marina Serban, Wang Ning, Hong Ming, Li Sha, Li Lei, Cheung Fan, Wen Xiao-Yan, Feng Yibin, Preclinical Models for Investigation of Herbal Medicines in Liver Diseases: Update and Perspective, Evidence-Based Complementary and Alternative Medicine, 2016, 2016. Crossref

  2. Shakya Arvind Kumar, Shukla Sangeeta, Protective effect of Sharbat-e-Deenar against acetaminophen-induced hepatotoxicity in experimental animals, Journal of Traditional Chinese Medicine, 37, 3, 2017. Crossref

  3. Daniyal Muhammad, Akram Muhammad, Zainab Rida, Munir Naveed, Sharif Aamir, Shah Syed Muhammad Ali, Liu Bin, Wang Wei, Prevalence and current therapy in chronic liver disorders, Inflammopharmacology, 27, 2, 2019. Crossref

  4. Shakya Arvind Kumar, Sharma Neetu, Bhadauria Monika, Nirala Satendra Kumar, Shrivastava Sadhana, Shukla Sangeeta, Ameliorative impact of herbal formulation —Majoon-Dabeed-ul-ward and Sharbat-e-Deenar against CCl4 induced liver toxicity via regulation of antioxidant enzymes and oxidative stress, Toxicology Research, 2022. Crossref

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