Suscripción a Biblioteca: Guest
Journal of Environmental Pathology, Toxicology and Oncology

Publicado 4 números por año

ISSN Imprimir: 0731-8898

ISSN En Línea: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Estimation of Cancer Risk Caused by Environmental Chemicals Based on In Vivo Dose Measurement

Volumen 20, Edición 4, 2001, 9 pages
DOI: 10.1615/JEnvironPatholToxicolOncol.v20.i4.20
Get accessGet access

SINOPSIS

Methods for estimating the risks, that is, the probabilities of contracting a disease, are required as a basis of decision-making regarding the needs for protection and risk reduction. A mechanism-based model has been developed for estimating the cancer risks from genotoxic chemicals using adducts to macromolecules for determining the in vivo dose. On the assumption that cancer is caused by an increased frequency of mutations in tissues, interacting with inherited or acquired growth-promoting factors, a simplified model has been proposed for estimating cancer risks from chemically reactive, that is, mutagenic agents. According to a multiplicative model, the risk increment (DP) is DP = b ґ D ґ P0, proportional to the background incidence (P0) and linearly dependent on dose at low to intermediate doses (D); b is the risk coefficient, which is approximately the same for different tumor sites and, probably, different species. This model is already in use for ionizing radiation and has been validated for a few mutagenic and carcinogenic chemical compounds. Inherent in this method is the measurement of dose. Sensitive chemical methods have been developed for determining reactive compounds and intermediates in vivo through their stable reaction products (adducts) with proteins, particularly hemoglobin. In humans or animals, the doses of genotoxic agents can be derived from measured levels of adducts and rates of adduct formation. This approach has been applied to various exposures such as air pollutants in occupational settings, carcinogens in foods, and tobacco smoke. By such methods, exposures to previously unknown mutagens and carcinogens may be detected and assessed in humans. Examples of this are epoxides (from endogenously produced alkenes) and compounds (such as acrylamide) formed in cooking foodstuffs.

CITADO POR
  1. Zhou Shuang, Wang Dan, Zhang Chen, Zhao Yunfeng, Zhao Meiping, Wu Yongning, A Novel Interaction Mode between Acrylamide and its Specific Antibody, Journal of Immunoassay and Immunochemistry, 36, 3, 2015. Crossref

  2. Chęć Ewa, Podgórska Beata, Węgrzyn Grzegorz, Comparison of the use of mussels and semipermeable membrane devices for monitoring and assessment of accumulation of mutagenic pollutants in marine environment in combination with a novel microbiological mutagenicity assay, Environmental Monitoring and Assessment, 140, 1-3, 2008. Crossref

  3. Törnqvist M., Paulsson B., Osterman-Golkar S., Biomonitoring of acrylamide, in Acrylamide and Other Hazardous Compounds in Heat-Treated Foods, 2006. Crossref

  4. Törnqvist M., Fred C., Haglund J., Helleberg H., Paulsson B., Rydberg P., Protein adducts: quantitative and qualitative aspects of their formation, analysis and applications, Journal of Chromatography B, 778, 1-2, 2002. Crossref

  5. Podgórska Beata, Królicka Aleksandra, Łojkowska Ewa, Węgrzyn Grzegorz, Rapid detection of mutagens accumulated in plant tissues using a novel Vibrio harveyi mutagenicity assay, Ecotoxicology and Environmental Safety, 70, 2, 2008. Crossref

  6. Podgórska Beata, Pazdro Ksenia, Pempkowiak Janusz, Węgrzyn Grzegorz, The use of a novel Vibrio harveyi luminescence mutagenicity assay in testing marine water for the presence of mutagenic pollution, Marine Pollution Bulletin, 54, 6, 2007. Crossref

  7. Dmochowska Barbara, Piosik Jacek, Woziwodzka Anna, Sikora Karol, Wiśniewski Andrzej, Węgrzyn Grzegorz, Mutagenicity of quaternary ammonium salts containing carbohydrate moieties, Journal of Hazardous Materials, 193, 2011. Crossref

  8. Motwani Hitesh V., Frostne Cecilia, Törnqvist Margareta, Parallelogram based approach for in vivo dose estimation of genotoxic metabolites in humans with relevance to reduction of animal experiments, Scientific Reports, 7, 1, 2017. Crossref

  9. Hecht Stephen S., Tobacco carcinogens, their biomarkers and tobacco-induced cancer, Nature Reviews Cancer, 3, 10, 2003. Crossref

  10. Boffetta P., Islami F., The contribution of molecular epidemiology to the identification of human carcinogens: current status and future perspectives, Annals of Oncology, 24, 4, 2013. Crossref

  11. Fred Charlotta, Törnqvist Margareta, Granath Fredrik, Evaluation of Cancer Tests of 1,3-Butadiene Using Internal Dose, Genotoxic Potency, and a Multiplicative Risk Model, Cancer Research, 68, 19, 2008. Crossref

  12. Vesper Hubert W., Bernert John T., Ospina Maria, Meyers Tunde, Ingham Leigha, Smith Antoinette, Myers Gary L., Assessment of the Relation between Biomarkers for Smoking and Biomarkers for Acrylamide Exposure in Humans, Cancer Epidemiology, Biomarkers & Prevention, 16, 11, 2007. Crossref

  13. Podgórska Beata, Pazdro Ksenia, Węgrzyn Grzegorz, The use of theVibrio harveyi luminescence mutagenicity assay as a rapid test for preliminary assessment of mutagenic pollution of marine sediments, Journal of Applied Genetics, 48, 4, 2007. Crossref

  14. Stewart Bernard W., Coates Alan S., Cancer Prevention: A Global Perspective, Journal of Clinical Oncology, 23, 2, 2005. Crossref

Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones Precios y Políticas de Suscripcione Begell House Contáctenos Language English 中文 Русский Português German French Spain