Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Journal of Environmental Pathology, Toxicology and Oncology
Factor de Impacto: 1.625 Factor de Impacto de 5 años: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN Imprimir: 0731-8898
ISSN En Línea: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v20.i1.10
7 pages

Stress-Inducible DNA Repair in Saccharomyces Cerevisiae

Naresh C. Verma
Radiation Biology Division, Bhabha Atomic Research Centre, Mumbai, Pin. (400 085), India
Rakesh K. Singh
Radiation Biology Division, Bhabha Atomic Research Centre, Mumbai, Pin. (400 085), India

SINOPSIS

Saccharomyces cereuisiae shows altered radiation response under various stress conditions, such as nutrition depletion, nitrogen starvation, osmotic shock, heat shock, and mild chemical treatments. In general, the cells show higher levels of UV or gamma radiation resistance under the stress. However, not all the stress conditions affect the repair system in the same manner. For example, depletion of nitrogen supply in the growth medium has been shown to enhance the repair of gamma ray-induced DNA damage without significantly affecting the UV response of the cells. On the other hand, a mild treatment with alkali or hydrogen peroxide improves the response to UV light but not to gamma radiation. It has further been shown that the effect of these stresses are not additive, e.g., the alkali and hydrogen peroxide treatments given simultaneously show the same effect as either of them alone. Low levels of gamma and UV radiation exposures are also treated as stress in the present context. Studies show that irradiation of low-dose gamma rays results in enhanced excision repair of UV-induced pyrimidine dimers. However, in all the wild-type strains tested, none showed any effect on gamma rays response. The exposure to low doses of UV light did not show any effect on either the gamma rays or the UV response. It is suggested that the stress-induced enhancement of DNA repair can be of two types: 1) A general response to stress, which prepares the organism to survive in adverse circumstances (some of the proteins produced during this response also take part in the DNA repair), and 2) a particular response involving DNA damage, such as that caused by gamma irradiation. In this case, the DNA damage may act as a signal for enhancement of the DNA repair.


Articles with similar content:

Radioadaptive Response in Human Lymphocytes in Vitro
Journal of Environmental Pathology, Toxicology and Oncology, Vol.20, 2001, issue 3
Ramesh C. Chaubey, Shree K. Apte, Pawan S. Chauhan, Subha Venkat
Replication of Damaged Genomes
Critical Reviews™ in Eukaryotic Gene Expression, Vol.21, 2011, issue 4
Alden C. Klarer, W. Glenn McGregor
The Influence of Nonprotein Thiols on DNA Damage Induced by Bleomycin in Single Human Cells
Journal of Environmental Pathology, Toxicology and Oncology, Vol.32, 2013, issue 3
Juan A. Gili, Anabela Mira, Daniel M. Lopez-Larraza
Effects of Ultraviolet Exposure on the Immune System
Critical Reviews™ in Immunology, Vol.21, 2001, issue 4
Johan Garssen, Henk van Loveren
Radioprotection and Antitumor Effect by Lyophyllum decastes Singer and Propolis in Mice
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 3
Masami Oshima, Yeunhwa Gu, Yuuichi Ukawa, In-Suk Choi, Toshihiro Maenaka, Ikukatsu Suzuki