Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Journal of Environmental Pathology, Toxicology and Oncology
Factor de Impacto: 1.625 Factor de Impacto de 5 años: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN Imprimir: 0731-8898
ISSN En Línea: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v20.i1.40
4 pages

A Common Regulator of Cold and Radiation Response in Escherichia coli

Suhas Mangoli
Molecular Biology and Agriculture Division, Bhabha Atomic Research Center,Trombay, Mumbai, India
Vibhav R. Sanzgiri
Hindustan Lever Research Center, Chakala, Andheri (E), Mumbai, India
Suresh K. Mahajan
Molecular Biology and Agriculture Division, Bhabha Atomic Research Center,Trombay, Mumbai, India

SINOPSIS

High levels of the protein product of gicA/cspE, a member of cspA family of cold stress genes, are known to be associated with several pleiotropic phenotypes in Escherichia coli. These include growth retardation in cold, suppression of rpsL31-mediated streptomycin resistance in cold, suppression of the chromosome partitioning mutation mukB, and cellular resistance to camphor. In this article, we demonstrate that the product of this gene is also involved in regulating UV and gamma radiation sensitivity. When present on a multicopy plasmid, gicA conferred UV sensitivity on those strains of E. coli K-12, in which it produces the cold-dependent growth retardation and streptomycin sensitivity but did not confer any gamma radiation sensitivity. A gicA::cat mutation, that inactivates the chromosomal gicA, made the cells highly sensitive to both UV and gamma radiation. These results indicate that the cellular level of GicA is quite critical in some aspects of DNA metabolism and suggest that this protein is a global regulator of multiple pathways affecting growth and translational fidelity in cold, DNA condensation, and chromosome partitioning during cell division.


Articles with similar content:

Involvement of Different Genes Expressions during Immunological and Inflammatory Responses in Vitiligo
Critical Reviews™ in Eukaryotic Gene Expression, Vol.27, 2017, issue 3
Monika Sharma, Chandra Kant Sharma, Kanika Prasad
Important Biology Events and Pathways in Brucella Infection and Implications for Novel Antibiotic Drug Targets
Critical Reviews™ in Eukaryotic Gene Expression, Vol.23, 2013, issue 1
Guangjun Gao, Jie Xu
Transcriptional Targets of p53 That Regulate Cellular Proliferation
Critical Reviews™ in Eukaryotic Gene Expression, Vol.17, 2007, issue 1
Lakshmi Raj, Lauren Brown, Sam W. Lee, Sarah Boswell
Genome Instability in the Context of Chromatin Structure and Fragile Sites
Critical Reviews™ in Eukaryotic Gene Expression, Vol.20, 2010, issue 3
Eva Bartova, Gabriela Galiova, Sona Legartova, Alzbeta Jugova, Lenka Stixova, Stanislav Kozubek
Two-Stage Gene Regulation of the Superoxide Stress Response soxRS System in Escherichia Coli
Critical Reviews™ in Eukaryotic Gene Expression, Vol.6, 1996, issue 4
Tatsuo Nunoshiba