RT Journal Article
ID 57f2d004703a4625
A1 Gade , Shruti 
A1 Gandhi, Nitin Motilal 
T1 Baicalein Inhibits MCF-7 Cell Proliferation <i>In Vitro</i>, Induces Radiosensitivity, and Inhibits Hypoxia Inducible Factor
JF Journal of Environmental Pathology, Toxicology and Oncology
JO JEP(T)
YR 2015
FD 2015-11-19
VO 34
IS 4
SP 299
OP 308
K1 Baicalein
K1 MCF-7 cells
K1 hypoxia inducible factor
K1 Comet assay
K1 radiotherapy
AB Hypoxia inducible factor (HIF) is a key transcription factor responsible for imparting adaptability to the cancer cells growing in tumors. HIF induces the modulation of glucose metabolism, angiogenesis, and prosurvival signaling. Therefore, HIF is one of the attractive targets to treat solid tumors. Results presented in this study indicate that Baicalein (BA) inhibits HIF stabilization and also reduces its transcription activity in MCF-7 cells <i>in vitro</i>. Furthermore, BA was found to have antiproliferative ability as determined by the MTT assay and clonogenic survival. BA also induces apoptosis in MCF-7 cells at the concentration of 50 &#181;M. We also report the radiosensitization of MCF-7 cells when they are treated with BA, resulting in higher &#947;-radiation&minus;induced DNA damage. BA is extensively used in Chinese medicine and is known to be nontoxic at pharmacological doses. Our studies indicate that BA is one of the attractive natural compounds suitable for further evaluation as an adjuvant therapy.
PB Begell House
LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,793887a16d3b8ded,57f2d004703a4625.html