RT Journal Article ID 33b8706e0684002b A1 Dandekar, Abhaya M. A1 Martinelli, Federico A1 Davis, Cristina E. A1 Bhushan, Abhinav A1 Zhao, Weixiang A1 Fiehn, Oliver A1 Skogerson, Kirsten A1 Wohlgemuth, Gert A1 D'Souza, Raissa A1 Roy, Soumen A1 Reagan, Russell L. A1 Lin, Dawei A1 Cary, R. Bruce A1 Pardington, Paige A1 Gupta, Goutam T1 Analysis of Early Host Responses for Asymptomatic Disease Detection and Management of Specialty Crops JF Critical Reviews™ in Immunology JO CRI YR 2010 FD 2010-04-02 VO 30 IS 3 SP 277 OP 289 K1 biological regulatory network K1 differential mobility spectrometry K1 gas chromatography-coupled time-of-fight mass spectrometry K1 huanglongbing K1 induced volatile organic compound K1 lateral flow microarray K1 microbe-associated molecular pattern K1 specialty crops K1 Twister AB The rapid and unabated spread of vector-borne diseases within US specialty crops threatens our agriculture, our economy, and the livelihood of growers and farm workers. Early detection of vector-borne pathogens is an essential step for the accurate surveillance and management of vector-borne diseases of specialty crops. Currently, we lack the tools that would detect the infectious agent at early (primary) stages of infection with a high degree of sensitivity and specificity. In this paper, we outline a strategy for developing an integrated suite of platform technologies to enable rapid, early disease detection and diagnosis of huanglongbing (HLB), the most destructive citrus disease. The research has two anticipated outcomes: i) identification of very early, disease-specific biomarkers using a knowledge base of translational genomic information on host and pathogen responses associated with early (asymptomatic) disease development; and ii) development and deployment of novel sensors that capture these and other related biomarkers and aid in presymptomatic disease detection. By combining these two distinct approaches, it should be possible to identify and defend the crop by interdicting pathogen spread prior to the rapid expansion phase of the disease. We believe that similar strategies can also be developed for the surveillance and management of diseases affecting other economically important specialty crops. PB Begell House LK https://www.dl.begellhouse.com/journals/2ff21abf44b19838,1629d2c3507c27c5,33b8706e0684002b.html