RT Journal Article ID 314f1a3a192db389 A1 Radisavljevic, Ziv T1 AKT as Locus of Cancer Positive Loops Conversion and Chemotherapy JF Critical Reviews™ in Eukaryotic Gene Expression JO CRE YR 2015 FD 2015-09-30 VO 25 IS 3 SP 199 OP 202 K1 AKT locus K1 positive loops conversion K1 locus chemotherapy K1 solid cancers K1 hematological malignancy AB A cancer positive-feedback loops conversion is the phenomenon and principal mechanism for AKT locus chemotherapy. Such chemotherapy is the approach to target cancer robustness and complexity through the AKT signaling locus. The hypoxic cancer microenvironment generates a powerful signaling interactome with positive-feedback loops that generates cancer robustness through the AKT locus. This complexity and robustness can be successfully halted in leukemia, lymphoma, myeloma, plasmocytoma, sarcoma, and carcinoma by converting cancer positive-feedback loops into negative-feedback loops, achieved through the AKT dephosphorylation by redox balancing change. The hyperphosphorylated AKT locus is down-regulated completely to AKT dephosphorylation by redox balancing change, causing conversion of positive-feedback loops and the disappearance of malignant robustness as a direct effect of AKT locus chemotherapy. PB Begell House LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,634f45605105f90b,314f1a3a192db389.html