RT Journal Article ID 2bfbf453156ab03c A1 Bidegain, Maximiliano A. A1 Postemsky, Pablo Daniel A1 Pieroni, Olga A1 Cubitto, Maria Amelia T1 Analysis of the Influence of Substrate Formulations on the Bioactive Chemical Profile of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes) by Conventional and Chemometrics Methods JF International Journal of Medicinal Mushrooms JO IJM YR 2019 FD 2019-06-05 VO 21 IS 6 SP 537 OP 548 K1 Ganoderma lucidum K1 sunflower seed hulls K1 rice agroresidues K1 copper K1 olive oil K1 infrared spectroscopy K1 medicinal mushrooms AB Ganoderma lucidum, a mushroom with medicinal properties, can grow on diverse lignocellulosic substrates. Substrate enrichment with additives has been used as a strategy to increase mushroom productivity. In this study, we evaluated the impact of substrate formulation on the bioactive chemical profile of the basidiome. The bioactive chemical profile of basidiomes cultivated on rice agro-residues (RA) or sunflower seed hulls (SSH) enriched with olive oil and/or copper was evaluated using conventional colorimetric methods and FT-MIR spectrometry coupled with chemometrics. The contents of total triterpenoids, ganoderic acids, high-molecular-weight carbohydrates, and phenolic compounds were sensitive to substrate formulation and harvest time. Moreover, cluster analysis and principal component analysis of the mid-IR spectra were able to discriminate between basidiomes cultivated on either RA or SSH substrates, and for SSH substrates between enriched and nonenriched formulas. These results indicate that the bioactive composition of G. lucidum can be influenced by the formulation of the cultivation substrate. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,27c0458a59ba057c,2bfbf453156ab03c.html