%0 Journal Article
%A Joshi, Deepmala
%A Kumar, Mittal Deepak
%A Kumar, Shakya Arvind
%A Sangeeta, Shukla
%D 2014
%I Begell House
%K methylmercury, N-acetyl cysteine, lipid peroxidation, dlutathione, DNA damage
%N 2
%P 167-182
%R 10.1615/JEnvironPatholToxicolOncol.2014010291
%T Reversal of Methylmercury-Induced Oxidative Stress, Lipid Peroxidation, and DNA Damage by the Treatment of N-Acetyl Cysteine: A Protective Approach
%U https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,249005dc454eb8de,2beb92d577c4b02c.html
%V 33
%X This study was designed to evaluate the protective effect of N-acetyl cysteine in reducing methylmercury (MeHg)−induced oxidative stress, lipid peroxidation, DNA damage in liver, kidney, and brain, and their ability to restore altered hepatic, renal, and other biochemical variables. Male Sprague-Dawley rats (150 ± 10 g) were randomly divided into three groups. Group 1 served as the control. Groups 2 and 3 were administered methylmercury (1 mg kg−1 orally, 5 days/week) for 12 weeks, and group 2 served as the experimental control. Group 3 received N-acetyl cysteine (0.6 mg kg−1 intraperitoneally, two days/week) for 12 weeks after methylmercury exposure. Methylmercury exposure caused a significant rise in bilirubin, gamma-glutamyl transpeptidase, protein, triglycerides, cholesterol, urea,
creatinine, uric acid, and blood urea nitrogen, with a concomitant decrease in albumin content, reduced glutathione
level and acetyl cholinesterase activity, antioxidant enzymes such as glutathione reductase, glutathione peroxidase, glucose-6-phosphate dehydrogenase, and adenosine triphosphatase. However, lipid peroxidation level, metallothionein expression, and DNA damage with increment of tail length were observed after methylmercury intoxication. N-acetyl cysteine, a widely available, nontoxic amino acid derivative, is a promising antioxidant with a wide spectrum of biological functions. The ability of N-acetyl cysteine to enhance mercury excretion and its wide availability in clinical use indicate that it may be an ideal therapeutic agent against methylmercury poisoning.
%8 2014-05-09