%0 Journal Article
%A Rubel, Rosalia
%A Santa, Herta Stutz Dalla
%A Fernandes, Luiz Claudio
%A Filho, Jose Hermenio Cavalcante Lima
%A Figueiredo, Bonald Cavalcante
%A Di Bernardi, Raffaello
%A Moreno, Andrea N.
%A Leifa, Fan
%A Soccol, Carlos Ricardo
%D 2008
%I Begell House
%N 1
%P 37-48
%R 10.1615/IntJMedMushr.v10.i1.50
%T High Immunomodulatory and Preventive Effects Against Sarcoma 180 in Mice Fed with Ling Zhi or Reishi Mushroom Ganoderma lucidum (W. Curt.: Fr.) P. Karst. (Aphyllophoromycetideae) Mycelium
%U https://www.dl.begellhouse.com/journals/708ae68d64b17c52,578eeec75bc66d7b,2b1a53f149c3d84e.html
%V 10
%X This study evaluated the immunomodulatory and antitumor effects of a diet supplemented with Ganoderma lucidum (Ling Zhi or Reishi) medicinal mushroom mycelium obtained by solid-state fermentation. Over 14 weeks, animals from a test group were fed with 2 concentrations of G. lucidum mycelium, at 85% or 50%, labeled G85 and G50 diets, respectively. A control group received a regular diet. In the tenth week, half the animals from the test group and half the animals from the control group were inoculated with a suspension of Sarcoma 180 cells. Saline was injected in the remaining animals. In week 14, plasma levels of cytokines and the population of CD3+, CD4+, CD8+, CD19+, and CD16+/ CD32+ cells were evaluated. When compared to the control group, G. lucidum-supplemented diets altered the immune systems of the mice significantly (p < 0.05) the G50 diet proving more effective than the G85 diet. Mice inoculated with saline and fed with the G50 diet presented an increase in CD19+ and CD16+/CD32+ cell populations, along with an elevation in the tumor necrosis factor (TNF)-α and interferon (IFN)-γ concentrations. Conversely, tumor-bearing mice fed with the G50 diet (labeled the G50-S group) presented an increase in CD3+, CD4+, and CD8+ cells, but a decrease in CD19+ and CD16+/ CD32+ cell populations. TNF-α and IFN-γ concentrations were reduced in the G50-S group. The G50-S group presented a tumor weight 84% lower than that found in the control group. These results suggest that the immunomodulatory effect provoked by the consumption of G. lucidum mycelium possibly increased mice resistance against Sarcoma 180.
%8 2008-02-08