RT Journal Article
ID 26b79a012773091d
A1 Mitra, Aparna
A1 Chakrabarti, Jayati
A1 Chatterjee, Amitava
A1 Chattopadhyay, Nibedita
T1 Membrane-Associated MMP-2 in Human Cervical Cancer
JF Journal of Environmental Pathology, Toxicology and Oncology
JO JEP(T)
YR 2003
FD 2003-06-01
VO 22
IS 2
OP 8
AB Matrixmetalloproteinases (MMPs) are a family of secreted or membrane-associated proteins capable of digesting extracellular matrix components. The importance of MMPs in tumor development and invasion is well known. Recent studies have strongly indicated the presence of a functional complex consisting of avb3 integrin, membrane type-1 metalloproteinase-2 (MT1-MMP), and tissue inhibitor of metalloproteinase-2 (TIMP-2) on tumor cell surface, which helps the activation of MMP-2. In this article, we report on the association of active MMP-2 with the membrane fraction of human cervical cancer cells. The association of MMP-2 with avb3 integrin and the expression of membrane type MT1-MMP strongly indicate the role of avb3/MT1-MMP/TIMP-2 complex in the activation of MMP-2 in cervical cancer tissue membrane fraction. The membrane-associated activated MMP-2 may have a role in the migration of tumor cells during invasion.
PB Begell House
LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,6131038a630e9e7e,26b79a012773091d.html