RT Journal Article
ID 22b0aab452f80fe2
A1 Yallapragada, Prabhakara Rao
A1 Velaga, Manoj Kumar
T1 Effect of Ginkgo biloba Extract on Lead-Induced Oxidative Stress in Different Regions of Rat Brain
JF Journal of Environmental Pathology, Toxicology and Oncology
JO JEP(T)
YR 2015
FD 2015-02-27
VO 34
IS 2
SP 161
OP 173
K1 Ginkgo biloba
K1 oxidative stress
K1 rat brain
K1 lead toxicity
K1 reactive oxygen species
AB Ginkgo biloba extract (GbE) is a well known natural antioxidant. In the present investigation, its ameliorative
effects were tested against lead-induced oxidative stress in rat brain. Four groups of male Wistar rats (100 to
120 g) were used, consisting of eight rats per group. Rats in the control group received 500 ppm of sodium acetate
through drinking water, and rats in the other three groups received 500 ppm of lead acetate through drinking water
for 4 weeks. Rats in the third and fourth groups were administered (oral) 50 and 100 mg/kg of GbE, respectively,
along with lead acetate. The rats were sacrificed after treatment and brains were isolated. Each brain was dissected
on ice, and different regions, namely the cerebellum, hippocampus, frontal cortex, and brainstem, were separated.
The results revealed a significant (P < .001) increase in reactive oxygen species, catalase, superoxide dismutase, lipid peroxidation products, and total protein carbonyl content, relative to their controls, in all four regions of the brain exposed to lead. These results indicate oxidative stress. Partial restoration was observed for all the parameters just mentioned in different brain regions on treatment with 50 mg/kg GbE. This amelioration was higher with 100 mg/kg GbE, showing dose-dependency. Overall the data suggest that GbE protects against lead-induced oxidative
stress in specific regions of rat brain.
PB Begell House
LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,0972237e0d0d4968,22b0aab452f80fe2.html