RT Journal Article
ID 1cb5fe9d1c31da44
A1 Gil-Ramirez, Alicia
A1 Smiderle, Fhernanda R.
A1 Morales, Diego
A1 Govers, Coen
A1 Synytsya, Andriy
A1 Wichers, Harry J.
A1 Iacomini, Marcello
A1 Soler-Rivas, Cristina
T1 Water-Soluble Polysaccharide Extracts from the Oyster Culinary-Medicinal Mushroom Pleurotus ostreatus (Agaricomycetes) with HMGCR Inhibitory Activity
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2017
FD 2017-11-29
VO 19
IS 10
SP 879
OP 892
K1 B-glucans
K1 Caco2
K1 cholesterol
K1 HMGCR
K1 medicinal mushrooms
K1 Pleurotus ostreatus
K1 polysaccharides
AB Water extracts from Pleurotus ostreatus containing no statins showed 3-hydroxy-3-methyl-glutaryl CoA
reductase (HMGCR) inhibitory activity (in vitro) that might be due to specific water-soluble polysaccharides (WSPs); when isolated and deproteinized, increasing concentrations of the WSP extract induced higher inhibition. The WSP extract contained mainly β-glucans, mannogalactans, and glycogen (e.g., α-glucans), although derivatives or fragments with lower molecular weights (between 14 and 3.5 kDa) were present and were able to induce the inhibitory activity. The extract contained more β-(1→3)-glucans than β-(11→3),(11→6)-glucans, and they partially survived digestion and managed to pass through Caco2 cell monolayers to the lower compartment after in vitro digestion and transport experiments. The WSP might also modulate Caco2 membrane integrity.
PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,305c54e9703680c8,1cb5fe9d1c31da44.html