RT Journal Article ID 126ac4134259fdaa A1 Chen , Yingwei A1 Jie, Wen A1 Yan, Weihui A1 Zhou, Kejun A1 Xiao, Yongtao T1 Lysine-specific histone demethylase 1 (LSD1): A potential molecular target for tumor therapy JF Critical Reviews™ in Eukaryotic Gene Expression JO CRE YR 2012 FD 2012-02-15 VO 22 IS 1 SP 53 OP 59 K1 LSD1 K1 cell proliferation K1 adipogenesis K1 spermatogenesis K1 chromosome segregation K1 structure AB Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, was belonged to the superfamily of the flavin adenine dinucleotide (FAD)-dependent amine oxidases. LSD1 specifically demethylates mono- or dimethylated dimethylated histone H3 lysine4 (H3K4) and H3 lysine 9 (H3K9) via a redox process. Recently evidences showed that LSD1 played an important role in a broad spectrum of biological processes, including cell proliferation, adipogenesis, spermatogenesis, chromosome segregation and embryonic development. Furthermore, LSD1 also could promote progress of tumor by inhibiting the tumor suppressor activity of p53. To date, as a potential drug for discovering anti-tumor drugs, the medical significance of LSD1 inhibitors have been greatly appreciated. Here, we reviewed the remarkable progress being made in understanding of LSD1, mainly on its structure, basic function and medical application in tumor therapy. PB Begell House LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,7b6c4b2a01f0c06f,126ac4134259fdaa.html